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  • Other Sources  (4)
  • Aerospace Medicine  (2)
  • Aircraft Design, Testing and Performance  (2)
  • Chemistry
  • General Chemistry
  • 2000-2004  (4)
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  • 1
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    Hindlimb unloading alters ligament healing (2003)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: We investigated the hypothesis that hindlimb unloading inhibits healing in fibrous connective tissue such as ligament. Male rats were assigned to 3- and 7-wk treatment groups with three subgroups each: sham control, ambulatory healing, and hindlimb-suspended healing. Ambulatory and suspended animals underwent surgical rupture of their medial collateral ligaments, whereas sham surgeries were performed on control animals. After 3 or 7 wk, mechanical and/or morphological properties were measured in ligament, muscle, and bone. During mechanical testing, most suspended ligaments failed in the scar region, indicating the greatest impairment was to ligament and not to bone-ligament insertion. Ligament testing revealed significant reductions in maximum force, ultimate stress, elastic modulus, and low-load properties in suspended animals. In addition, femoral mineral density, femoral strength, gastrocnemius mass, and tibialis anterior mass were significantly reduced. Microscopy revealed abnormal scar formation and cell distribution in suspended ligaments with extracellular matrix discontinuities and voids between misaligned, but well-formed, collagen fiber bundles. Hence, stress levels from ambulation appear unnecessary for formation of fiber bundles yet required for collagen to form structurally competent continuous fibers. Results support our hypothesis that hindlimb unloading impairs healing of fibrous connective tissue. In addition, this study provides compelling morphological evidence explaining the altered structure-function relationship in load-deprived healing connective tissue.
    Keywords: Aerospace Medicine
    Type: Journal of applied physiology (Bethesda, Md. : 1985) (ISSN 8750-7587); Volume 94; 1; 314-24
    Format: text
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    NASA TECHNICAL REPORTS
  • 2
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    NASA Langley Research Center's Simulation-To-Flight Concept Accomplished through the Integration Laboratories of the Transport Research Facility (2004)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The Flight Simulation and Software Branch (FSSB) at NASA Langley Research Center (LaRC) maintains the unique national asset identified as the Transport Research Facility (TRF). The TRF is a group of facilities and integration laboratories utilized to support the LaRC's simulation-to-flight concept. This concept incorporates common software, hardware, and processes for both groundbased flight simulators and LaRC s B-757-200 flying laboratory identified as the Airborne Research Integrated Experiments System (ARIES). These assets provide Government, industry, and academia with an efficient way to develop and test new technology concepts to enhance the capacity, safety, and operational needs of the ever-changing national airspace system. The integration of the TRF enables a smooth continuous flow of the research from simulation to actual flight test.
    Keywords: Aircraft Design, Testing and Performance
    Type: AIAA Paper 2004-4934 , AIAA Modeling and Simulation Technologies Conference; Aug 16, 2004 - Aug 19, 2004; Providence, RI; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Flexible Wing Base Micro Aerial Vehicles: Composite Materials for Micro Air Vehicles (2002)
    In:  CASI
    Details
    Publication Date: 2019-07-10
    Description: This paper will discuss the development of the University of Florida's Micro Air Vehicle concept. A series of flexible wing based aircraft that possess highly desirable flight characteristics were developed. Since computational methods to accurately model flight at the low Reynolds numbers associated with this scale are still under development, our effort has relied heavily on trial and error. Hence a time efficient method was developed to rapidly produce prototype designs. The airframe and wings are fabricated using a unique process that incorporates carbon fiber composite construction. Prototypes can be fabricated in around five man-hours, allowing many design revisions to be tested in a short period of time. The resulting aircraft are far more durable, yet lighter, than their conventional counterparts. This process allows for thorough testing of each design in order to determine what changes were required on the next prototype. The use of carbon fiber allows for wing flexibility without sacrificing durability. The construction methods developed for this project were the enabling technology that allowed us to implement our designs. The resulting aircraft were the winning entries in the International Micro Air Vehicle Competition for the past two years. Details of the construction method are provided in this paper along with a background on our flexible wing concept.
    Keywords: Aircraft Design, Testing and Performance
    Format: application/pdf
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  • 4
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    Dynamic Foot Stimulation Attenuates Soleus Muscle Atrophy Induced by Hindlimb Unloading in Rats (2004)
    In:  CASI
    Details
    Publication Date: 2019-07-12
    Description: Unloading-induced myofiber atrophy is a phenomenon that occurs in the aging population, bed-ridden patients and astronauts. The objective of this study was to determine whether or not dynamic foot stimulation (DFS) applied to the plantar surface of the rat foot can serve as a countermeasure to the soleus muscle atrophy normally observed in hindlimb unloaded (HU) rats. Thirty mature adult (6-month-old) male Wistar rats were randomly assigned into ambulatory control (AMB), hindlimb unloaded alone (HU), or hindlimb unloaded with the application of DFS (HU+DFS) groups. A dynamic pattern of pressure was applied to the right foot of each HU animal using a specially fabricated boot containing an inflatable air bladder connected to a solenoid air pump controlled by a laptop computer. The anti-atrophic effects of DFS were quantified morphometrically in frozen cross-sections of soleus muscle stained using the metachromatic-ATPase fiber typing technique. Application of DFS during HU significantly counteracted the atrophic response observed in the soleus by preventing approximately 85% of the reduction in Type I myofiber cross-sectional area (CSA) observed during HU. However, DFS did not protect type II fibers of the soleus from HU-induced atrophy or any fiber type in the soleus muscle of the contralateral control leg of the DFS-treated HU animals. These results illustrate that the application of DFS to the rat foot is an effective countermeasure to soleus muscle atrophy induced by HU.
    Keywords: Aerospace Medicine
    Type: JSC-CN-8748
    Format: application/pdf
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