Publication Date:
2001-04-21
Description:
As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection. Eye transplantation experiments show that astray function is required in the eye. We identify astray as zebrafish robo2, a member of the Roundabout family of axon guidance receptors. Retinal ganglion cells express robo2 as they extend axons. Thus, robo2 is required for multiple axon guidance decisions during establishment of the vertebrate visual projection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fricke, C -- Lee, J S -- Geiger-Rudolph, S -- Bonhoeffer, F -- Chien, C B -- R01-EY12873/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2001 Apr 20;292(5516):507-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology and Anatomy, University of Utah Medical Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11313496" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Axons/*physiology
;
Body Patterning
;
Chromosome Mapping
;
Crosses, Genetic
;
Eye/embryology/transplantation
;
Female
;
Gene Expression Regulation, Developmental
;
Genes
;
In Situ Hybridization
;
Male
;
Mutation
;
Nerve Tissue Proteins/*genetics/physiology
;
Phenotype
;
Receptors, Immunologic/*genetics/*physiology
;
Retina/embryology/metabolism
;
Retinal Ganglion Cells/metabolism/*physiology
;
Superior Colliculi/cytology/*embryology
;
Visual Pathways/embryology
;
Zebrafish/embryology/genetics
;
Zebrafish Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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