Publication Date:
2004-02-28
Description:
Legionella pneumophila, the bacterial agent of legionnaires' disease, replicates intracellularly within a specialized vacuole of mammalian and protozoan host cells. Little is known about the specialized vacuole except that the Icm/Dot type IV secretion system is essential for its formation and maintenance. The Legionella genome database contains two open reading frames encoding polypeptides (LepA and LepB) with predicted coiled-coil regions and weak homology to SNAREs; these are delivered to host cells by an Icm/Dot-dependent mechanism. Analysis of mutant strains suggests that the Lep proteins may enable the Legionella to commandeer a protozoan exocytic pathway for dissemination of the pathogen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, John -- de Felipe, Karim Suwwan -- Clarke, Margaret -- Lu, Hao -- Anderson, O Roger -- Segal, Gil -- Shuman, Howard A -- NIH-R01 AI23549/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Feb 27;303(5662):1358-61.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14988561" target="_blank"〉PubMed〈/a〉
Keywords:
Acanthamoeba/*microbiology/physiology/ultrastructure
;
Animals
;
Bacterial Proteins/genetics/metabolism/*physiology
;
Cell Line
;
Colony Count, Microbial
;
Cyclic AMP/metabolism
;
Dictyostelium/*microbiology/physiology/ultrastructure
;
Exocytosis
;
Genome, Bacterial
;
Humans
;
Legionella pneumophila/*genetics/growth & development/pathogenicity/*physiology
;
Lysosomes/physiology
;
Macrophages/microbiology/ultrastructure
;
Mutation
;
Open Reading Frames
;
Phagosomes/physiology
;
Recombinant Fusion Proteins/metabolism
;
Vacuoles/microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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