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  • AGE; Age, comment; Age, maximum/old; Age, minimum/young; Interpretation from literature (PKDB); Latitude of event; Longitude of event; Paleoclimate Database of the Quaternary; PKDB; PKDB286426; Precipitation, relative difference; Temperature, air; Temperature, relative difference  (1)
  • Pyelonephritis/microbiology  (1)
  • 2000-2004  (2)
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  • 2000-2004  (2)
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  • 1
    Publication Date: 2001-09-22
    Description: Comprehensive genomic analysis of the important human pathogen Staphylococcus aureus was achieved by a strategy involving antisense technology in a regulatable gene expression system. In addition to known essential genes, many genes of unknown or poorly defined biological function were identified. This methodology allowed gene function to be characterized in a comprehensive, defined set of conditionally growth-defective/lethal isogenic strains. Quantitative titration of the conditional growth effect was performed either in bacterial culture or in an animal model of infection. This genomic strategy offers an approach to the identification of staphylococcal gene products that could serve as targets for antibiotic discovery.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ji, Y -- Zhang, B -- Van, S F -- Horn -- Warren, P -- Woodnutt, G -- Burnham, M K -- Rosenberg, M -- New York, N.Y. -- Science. 2001 Sep 21;293(5538):2266-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Genetics Research, GlaxoSmithKline Pharmaceuticals Research and Development, Collegeville, PA 19426, USA. yinduo_ji-1@gsk.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11567142" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cloning, Molecular ; Female ; *Gene Expression Regulation, Bacterial ; *Genes, Bacterial ; *Genes, Essential ; Genetic Vectors ; Mice ; Open Reading Frames ; Phenotype ; Pyelonephritis/microbiology ; *RNA, Antisense ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/*genetics/growth & development/pathogenicity ; Transformation, Bacterial ; Virulence/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    In:  Supplement to: Zhang, B Z; Zhang, P X; Lowenstein, Tim K; Spencer, R J (1995): Time range of the great ice age of the last glacial stage and its related geological event of playa in the Qinghai-Xizang (Tibet) Plateau. (doi:cnki:ISSN:10017410.0.1995-03-000 not valid), Quaternary Sciences, 3, 192-201
    Publication Date: 2023-05-02
    Description: Fluid inclusions of protogenous halite, which were collected from two boreholes in the Charhan Salt Lake in the north part of the Qinghai-Xizang Plateau, werea nalyzed for their hydrogen and oxygen isotopes and for their Na, Mg etc. ions.On these grounds, the evolution of lake environment in this region during the last 50 000 years are discussed in this paper. The emphasis is to discuss the time range of extremely arid and cold climate at the last Glacial stage and the geological event of playa associated with such a climate.The guanidine hydrochloride method was used for measurement of hydrogen and oxygen stable isotopes. The measurement of Na, Mg etc. ions were achieved by determination of crystallization temperature of hydrohalite under microscope and then by calculation of chemical compositions of inclusion fluid using a thermodynamic model.The results obtained show that protogenous halite in the Charhan Lake area was formed in three different environment conditions: (1) In fluid inclusions of halite formed in the early period (50 000-30 000 a B. P. ), dD averages -14.9 per mil, d(18)O averages 8.37 per mil, and Mg(2+)ranges from 0.42 to 1.59 mol/L. Their plotting points fall on the right top part of the evaporation line of the present Charhan Lake area, indicating that the Lake water at that time had a higher concentration of brine, and the climate was hot and dry. (2) In fluid inclusions of halite formed in the middle period (30 000-15 000 a B. P.), SD average -66.0 per mil, d(18)O averages 1.00 pr mil, and Mg(2+) 1 mol/L. Their plotting points fall on the left low part of the evaporation line, indicating that the lake water at that time had a concentration of brine lower than that in the early period, and the environment was cold and dry. (3) In fluid inclusions of halite formed in the late period (15 000-present), dD averages 30.8 per mil, d(18)O averages 5.85 per mil, and Mg(2+) M 1 mol/L. Their plotting fall on the evaporation line, indicating that the climate environment at that time was warm and dry, almost the same as the present.The temperature variation of the last 50 000 years in the Charhan Lake area was calculated using the conversion equation proposed by Lorious et al. The time range of the Great ice age of the Last Glacial Stage is about 21 000-15 000 a B.P., which basically coincides with the time of a worldwide low sea level. The temperature in that period was below 0°C and 6-7°C lower than now. Because of lower temperatures, water supply to the lake area decreased rapidly and the concentration of lake water increased sharply. Therefore the Mg(2+) concentration in inclusion fluid reaches or closes to 2mol/L and the Mg/Na ratio varies within a very wide range. These show that the Charhan Lake at that time entered its playa stage. The Charhan Salt Lake is a typical one in the north part of the Qinghai-Xizang Plateau. It can be supposed that the extremely arid and cold climate of the Great Ice Age made most lakes in the north part of the Qinghai-Xizang Plateau enter their playa stage. This event is of importance for formation of salt resources.
    Keywords: AGE; Age, comment; Age, maximum/old; Age, minimum/young; Interpretation from literature (PKDB); Latitude of event; Longitude of event; Paleoclimate Database of the Quaternary; PKDB; PKDB286426; Precipitation, relative difference; Temperature, air; Temperature, relative difference
    Type: Dataset
    Format: text/tab-separated-values, 10 data points
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