Publication Date:
2003-03-01
Description:
Nonhuman primates represent the most relevant model organisms to understand the biology of Homo sapiens. The recent divergence and associated overall sequence conservation between individual members of this taxon have nonetheless largely precluded the use of primates in comparative sequence studies. We used sequence comparisons of an extensive set of Old World and New World monkeys and hominoids to identify functional regions in the human genome. Analysis of these data enabled the discovery of primate-specific gene regulatory elements and the demarcation of the exons of multiple genes. Much of the information content of the comprehensive primate sequence comparisons could be captured with a small subset of phylogenetically close primates. These results demonstrate the utility of intraprimate sequence comparisons to discover common mammalian as well as primate-specific functional elements in the human genome, which are unattainable through the evaluation of more evolutionarily distant species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boffelli, Dario -- McAuliffe, Jon -- Ovcharenko, Dmitriy -- Lewis, Keith D -- Ovcharenko, Ivan -- Pachter, Lior -- Rubin, Edward M -- HL66728/HL/NHLBI NIH HHS/ -- R01-HG02362-01/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2003 Feb 28;299(5611):1391-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉U.S. Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12610304" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Apolipoproteins A/genetics
;
Biological Evolution
;
Cebidae/genetics
;
Cercopithecidae/genetics
;
Computational Biology
;
Conserved Sequence
;
DNA-Binding Proteins/metabolism
;
Electrophoretic Mobility Shift Assay
;
Exons
;
Gene Expression Regulation
;
*Genome
;
*Genome, Human
;
Hominidae/genetics
;
Humans
;
Hylobates/genetics
;
Likelihood Functions
;
*Phylogeny
;
Primates/*genetics
;
Regulatory Sequences, Nucleic Acid
;
*Sequence Analysis, DNA
;
Species Specificity
;
Tumor Cells, Cultured
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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