Publication Date:
2000-02-11
Description:
The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell-mediated lysis by interacting with CD94/NKG2A receptors. Surface expression of HLA-E depends on binding of conserved peptides derived from MHC class I molecules. The same peptide is present in the leader sequence of the human cytomegalovirus (HCMV) glycoprotein UL40 (gpUL40). It is shown that, independently of the transporter associated with antigen processing, gpUL40 can up-regulate expression of HLA-E, which protects targets from NK cell lysis. While classical MHC class I molecules are down-regulated, HLA-E is up-regulated by HCMV. Induction of HLA-E surface expression by gpUL40 may represent an escape route for HCMV.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tomasec, P -- Braud, V M -- Rickards, C -- Powell, M B -- McSharry, B P -- Gadola, S -- Cerundolo, V -- Borysiewicz, L K -- McMichael, A J -- Wilkinson, G W -- New York, N.Y. -- Science. 2000 Feb 11;287(5455):1031.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10669413" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Amino Acid Substitution
;
*Antigens, CD
;
Cell Line
;
Cell Membrane/immunology
;
Cells, Cultured
;
Conserved Sequence
;
Cytomegalovirus/genetics/immunology/*metabolism
;
Cytotoxicity, Immunologic
;
Down-Regulation
;
HLA Antigens/immunology/*metabolism
;
Histocompatibility Antigens Class I/immunology/*metabolism
;
Humans
;
Killer Cells, Natural/*immunology
;
Molecular Sequence Data
;
Open Reading Frames
;
Protein Sorting Signals/chemistry/*metabolism
;
Receptors, Immunologic/metabolism
;
Recombinant Fusion Proteins/chemistry/metabolism
;
Transfection
;
Up-Regulation
;
Viral Proteins/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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