ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Mitochondrial DNA  (5)
  • Springer  (5)
  • Oxford University Press
  • 2000-2004  (5)
Collection
Keywords
Publisher
  • Springer  (5)
  • Oxford University Press
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Molecular analysis of α-thalassemia in Nepal: correlation with malaria endemicity (2000)
    Springer
    Journal of human genetics 45 (2000), S. 127-132 
    Details
    ISSN: 1435-232X
    Keywords: Key words Thalassemia ; Globin ; Genotype ; Haplotype ; Nepal ; Malaria ; Mitochondrial DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Thalassemia is a prevalent hereditary disorder characterized by impaired synthesis of globin chains. It has been suggested that the high frequency of thalassemia might reflect heterozygote advantage due to reduced susceptibility to malaria. In Nepal, malaria has often occurred in places below the altitude of 1200 m. We carried out a microepidemiological study on thalassemia in two neighboring populations in Nepal, the Danuwar and the Tamang. Settlements of the Danuwar are located below the limit of the malarial zone (1200 m in altitude), whereas those of the Tamang are found in malaria-free uplands. Three heterozygotes for hemoglobin (HbE) were observed in the Danuwars. We detected one type (−α3.7I) of α+-thalassemia that involves a deletion of 3.7 kb, leading to a loss of one of two α-globin genes, in the Danuwars, at a high gene frequency of 63%, while the gene frequency in the Tamangs was only 5%. Analysis of the α-globin gene cluster revealed that four different haplotypes were associated with the type of α+-thalassemia in the Danuwars. Nucleotide sequences of the D-loop region in the mitochondrial DNA of the two populations indicated a similar nucleotide diversity in each population. The fixation index, FST, representing the degree of genetic differentiation estimated from mitochondrial DNA diversities (FST, 0.05), was smaller than that obtained from the gene frequencies of α+-thalassemia (FST, 0.55). If we assume neutral molecular evolution in the D-loop region of mitochondrial DNA, these results suggest that the high frequency of α+-thalassemia may be due to biological adaptation to the malarial environment rather than to events such as a bottleneck.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050198
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Morphological changes in homeotic cytoplasmic male-sterile carrots combined with fertile cytoplasm by asymmetrical cell fusion (2000)
    Springer
    Plant cell reports 19 (2000), S. 363-370 
    Details
    ISSN: 1432-203X
    Keywords: Key words Daucus carota L. ; Mitochondrial DNA ; Repeated cell fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The cytoplasmic male-sterile (CMS) carrot (Daucus carota ssp. sativus) with the petaloid phenotype was asymmetrically fused with eight different fertile cytoplasms to convert the CMS to a fertile state. Restoration to the fertile phenotype was successful with an over 20% efficiency. Cybrids with brown anther sterile, incomplete petaloid sterile, or "combined flower" fused on the same axis were also observed. Restricted DNA fragment patterns revealed that the mitochondrial genome organizations of the cybrids were not identical to those of their parents but were of an intermediate type. Repeated cell fusion to introduce two different foreign cytoplasms into the CMS cytoplasm was effective for obtaining fertile plants. The role of mitochondrial factors which regulate flower organ morphogenesis was demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002990050741
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Organisation and expression of mitochondrial atp9 genes from CMS and fertile carrots (2000)
    Springer
    Theoretical and applied genetics 100 (2000), S. 263-270 
    Details
    ISSN: 1432-2242
    Keywords: Key words Cytoplasmic male sterility ; F0-F1 ATPase subunit 9 ; Mitochondrial DNA ; Carrot ; Daucus carota
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  The F0-F1 ATPase subunit 9 gene of carrot mitochondria has been isolated from both petaloid male-sterile (atp9-1) and normal fertile cytoplasms (atp9-3). The position occupied in atp9-3 by the TAA stop codon is, in the case of atp9-1 replaced by the CAA triplet coding for glutamine, which makes this latter ORF 13 amino acid residues longer than that of the atp9-3. The 3’ end of atp9-3 gene is flanked by a direct repeat of 42 bp. The sequence of the repeat unit is also present at the 3’ end of atp9-1 but without reiteration. A truncated and presumably inactive version of atp9 (atp9-2) was found to be present in cytoplasms regardless of the fertility phenotype which they condition. The atp9-1 gene from petaloid cytoplasm appeared to be co-transcribed with the gene coding for 5S rRNA, and nuclear background influenced the accumulation of the respective transcript. The results are discussed with respect to a potential role of atp9-1 in generating the petaloid form of CMS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050035
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization (2000)
    Springer
    Molecular genetics and genomics 263 (2000), S. 514-519 
    Details
    ISSN: 1617-4623
    Keywords: Key wordsDictyostelium discoideum ; Mitochondrial DNA ; Genome sequencing ; Genetic map ; Evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We present an overview of the gene content and organization of the mitochondrial genome of Dictyostelium discoideum. The mitochondria genome consists of 55,564 bp with an A + T content of 72.6%. The identified genes include those for two ribosomal RNAs (rnl and rns), 18 tRNAs, ten subunits of the NADH dehydrogenase complex (nad1, 2, 3, 4, 4L, 5, 6, 7, 9 and 11), apocytochrome b (cytb), three subunits of the cytochrome oxidase (cox1/2 and 3), four subunits of the ATP synthase complex (atp1, 6, 8 and 9), 15 ribosomal proteins, and five other ORFs, excluding intronic ORFs. Notable features of D. discoideum mtDNA include the following. (1) All genes are encoded on the same strand of the DNA and a universal genetic code is used. (2) The cox1 gene has no termination codon and is fused to the downstream cox2 gene. The 13 genes for ribosomal proteins and four ORF genes form a cluster 15.4 kb long with several gene overlaps. (3) The number of tRNAs encoded in the genome is not sufficient to support the synthesis of mitochondrial protein. (4) In total, five group I introns reside in rnl and cox1/2, and three of those in cox1/2 contain four free-standing ORFs. We compare the genome to other sequenced mitochondrial genomes, particularly that of Acanthamoeba castellanii.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00008685
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Functional specificity of the mitochondrial DnaJ protein, Mdj1p, in Saccharomyces cerevisiae (2000)
    Springer
    Molecular genetics and genomics 263 (2000), S. 527-534 
    Details
    ISSN: 1617-4623
    Keywords: Key words Mitochondrial DnaJ ; Mdj1p ; Mitochondrial DNA ; Complementation ; Chaperone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Inactivation of the gene for the mitochondrial DnaJ homolog, Mdj1p, in Saccharomyces cerevisiae results in temperature sensitivity and the loss of respiratory activity; the latter phenotype has been attributed to the loss of mitochondrial DNA. To investigate the functional specificity of Mdj1p, non-mitochondrial DnaJ proteins were targeted to mitochondria and tested for their ability to substitute for Mdj1p. The tested DnaJ proteins were able to complement the two Mdj1p-linked phenotypes, i.e., respiratory activity and growth at 37 °C, to different extents, ranging from full to very poor complementation. All DnaJ homologs ensured faithful propagation of the mitochondrial genome. N-terminal fragments of Mdj1p and Escherichia coli DnaJ comprising the well-characterized J domain partially substituted for Mdj1p. As the only hitherto known function of the N-terminal fragment is modulation of the substrate binding activity of the cognate Hsp70, we conclude that both Mdj1p-linked phenotypes – maintenance of respiratory activity and the ability to grow at elevated temperature – involve a mitochondrial Hsp70 partner protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004380051198
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...