Publication Date:
2004-11-16
Description:
Methionine synthase (MS) is a key enzyme involved in remethylation of homocysteine to methionine. We tested the hypothesis that deficiency of MS influences endothelial function. Mice heterozygous for disruption of the Ms gene (Ms+/−), and wild type littermates (Ms+/+), were fed either a control diet or a low folate (LF) diet. Plasma total homocysteine was similar in Ms+/+ and Ms+/− mice fed the control diet (4.5±0.3 and 5.3±0.4 μmol/L, respectively), and was mildly elevated in Ms+/+ or Ms+/− mice fed the LF diet (7.5±0.7 and 9.6±1.2 μmol/L, respectively; p
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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