ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • American Association for the Advancement of Science (AAAS)  (136)
  • American Geophysical Union (AGU)
  • 2000-2004  (136)
  • 11
    facet.materialart.
    Unknown
    Immunology. Long live the mature B cell--a baffling mystery resolved (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-09-15
    Description: What determines whether transitional B cells newly emerged from the bone marrow will differentiate further to become mature, long-lived, circulating B lymphocytes? In a Perspective, Waldschmidt and Noelle discuss new findings showing that the TNF family ligand BAFF and its receptor BAFF-R are crucial for selecting transitional B cells into the mature B cell pool (Thompson et al., Schiemann et al.).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Waldschmidt, T J -- Noelle, R J -- New York, N.Y. -- Science. 2001 Sep 14;293(5537):2012-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11557866" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Cell Activating Factor ; B-Cell Activation Factor Receptor ; B-Cell Maturation Antigen ; B-Lymphocytes/*immunology/metabolism/*physiology ; Bone Marrow Cells ; Cell Survival ; Immunoglobulin M/biosynthesis ; Ligands ; Membrane Proteins/*metabolism ; Mice ; Mice, Inbred A ; Mice, Knockout ; Mice, Mutant Strains ; Receptors, Tumor Necrosis Factor/genetics/*metabolism ; Signal Transduction ; Spleen/cytology/immunology ; Transmembrane Activator and CAML Interactor Protein ; Tumor Necrosis Factor-alpha/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 12
    facet.materialart.
    Unknown
    Polytype distribution in circumstellar silicon carbide (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-08
    Description: The inferred crystallographic class of circumstellar silicon carbide based on astronomical infrared spectra is controversial. We have directly determined the polytype distribution of circumstellar SiC from transmission electron microscopy of presolar silicon carbide from the Murchison carbonaceous meteorite. Only two polytypes (of a possible several hundred) were observed: cubic 3C and hexagonal 2H silicon carbide and their intergrowths. We conclude that this structural simplicity is a direct consequence of the low pressures in circumstellar outflows and the corresponding low silicon carbide condensation temperatures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daulton, T L -- Bernatowicz, T J -- Lewis, R S -- Messenger, S -- Stadermann, F J -- Amari, S -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1852-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Materials Science Division, Argonne National Laboratory, Argonne IL, 60439-4838, USA. tdaulton@nrlssc.navy.mil〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052956" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomical Phenomena ; *Astronomy ; Carbon Compounds, Inorganic/*analysis ; *Meteoroids ; Microscopy, Electron ; Pressure ; Silicon Compounds/*analysis ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 13
    facet.materialart.
    Unknown
    A heat-sensitive TRP channel expressed in keratinocytes (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-23
    Description: Mechanical and thermal cues stimulate a specialized group of sensory neurons that terminate in the skin. Three members of the transient receptor potential (TRP) family of channels are expressed in subsets of these neurons and are activated at distinct physiological temperatures. Here, we describe the cloning and characterization of a novel thermosensitive TRP channel. TRPV3 has a unique threshold: It is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures. TRPV3 is specifically expressed in keratinocytes; hence, skin cells are capable of detecting heat via molecules similar to those in heat-sensing neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peier, Andrea M -- Reeve, Alison J -- Andersson, David A -- Moqrich, Aziz -- Earley, Taryn J -- Hergarden, Anne C -- Story, Gina M -- Colley, Sian -- Hogenesch, John B -- McIntyre, Peter -- Bevan, Stuart -- Patapoutian, Ardem -- New York, N.Y. -- Science. 2002 Jun 14;296(5575):2046-9. Epub 2002 May 16.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016205" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Animals, Newborn ; Blotting, Northern ; CHO Cells ; Capsaicin/*analogs & derivatives/pharmacology ; *Cation Transport Proteins ; Cell Line ; Cells, Cultured ; Cloning, Molecular ; Cricetinae ; Epidermis/cytology/innervation/metabolism ; Ganglia, Spinal/metabolism ; *Hot Temperature ; Humans ; In Situ Hybridization ; Ion Channels/chemistry/genetics/*metabolism ; Keratinocytes/*metabolism ; Membrane Potentials ; Mice ; Molecular Sequence Data ; Nerve Endings/physiology ; Neurons/physiology ; Patch-Clamp Techniques ; RNA, Messenger/genetics/metabolism ; Ruthenium Red/pharmacology ; Signal Transduction ; Spinal Cord/metabolism ; TRPV Cation Channels ; Temperature
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 14
    facet.materialart.
    Unknown
    Potent analgesic effects of GDNF in neuropathic pain states (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-10-06
    Description: Neuropathic pain arises as a debilitating consequence of nerve injury. The etiology of such pain is poorly understood, and existing treatment is largely ineffective. We demonstrate here that glial cell line-derived neurotrophic factor (GDNF) both prevented and reversed sensory abnormalities that developed in neuropathic pain models, without affecting pain-related behavior in normal animals. GDNF reduces ectopic discharges within sensory neurons after nerve injury. This may arise as a consequence of the reversal by GDNF of the injury-induced plasticity of several sodium channel subunits. Together these findings provide a rational basis for the use of GDNF as a therapeutic treatment for neuropathic pain states.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boucher, T J -- Okuse, K -- Bennett, D L -- Munson, J B -- Wood, J N -- McMahon, S B -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):124-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Neuroscience Research, King's College London, London SE1 7EH, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11021795" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Analgesics, Non-Narcotic/pharmacology/*therapeutic use ; Animals ; Ganglia, Spinal/physiopathology ; Glial Cell Line-Derived Neurotrophic Factor ; Hot Temperature ; Hyperalgesia/*drug therapy ; Ligation ; Nerve Fibers/drug effects/physiology ; Nerve Fibers, Myelinated/drug effects/physiology ; *Nerve Growth Factors ; Nerve Tissue Proteins/pharmacology/*therapeutic use ; Neural Conduction/drug effects ; Neurons, Afferent/drug effects/physiology ; Pain/*drug therapy ; Pain Threshold/drug effects ; Peripheral Nervous System Diseases/*physiopathology ; Rats ; Reverse Transcriptase Polymerase Chain Reaction ; Sciatic Nerve ; Sodium Channels/genetics/metabolism ; Spinal Nerves ; Touch
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 15
    facet.materialart.
    Unknown
    Therapeutic approaches to bone diseases (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-01
    Description: The strength and integrity of our bones depends on maintaining a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result of disease, this delicate balancing act becomes tipped in favor of osteoclasts so that bone resorption exceeds bone formation, rendering bones brittle and prone to fracture. A better understanding of the biology of osteoclasts and osteoblasts is providing opportunities for developing therapeutics to treat diseases of bone. Drugs that inhibit the formation or activity of osteoclasts are valuable for treating osteoporosis, Paget's disease, and inflammation of bone associated with rheumatoid arthritis or periodontal disease. Far less attention has been paid to promoting bone formation with, for example, growth factors or hormones, an approach that would be a valuable adjunct therapy for patients receiving inhibitors of bone resorption.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rodan, G A -- Martin, T J -- New York, N.Y. -- Science. 2000 Sep 1;289(5484):1508-14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Merck Research Laboratories, West Point, PA 19486, USA. St. Vincent's Institute of Medical Research, Melbourne 3065, Australia. gideon_rodan@merck.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10968781" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bone Diseases/*drug therapy/genetics/physiopathology/therapy ; Bone Resorption/drug therapy ; Calcitonin/therapeutic use ; Diphosphonates/therapeutic use ; Estrogen Receptor Modulators/therapeutic use ; Estrogens/therapeutic use ; Female ; Genetic Therapy ; Growth Substances/therapeutic use ; Humans ; Male ; Osteoclasts/drug effects ; Osteogenesis/drug effects ; Osteoporosis/*drug therapy/genetics/physiopathology/therapy ; Parathyroid Hormone/therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 16
    facet.materialart.
    Unknown
    Causes of climate change over the past 1000 years (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-15
    Description: Recent reconstructions of Northern Hemisphere temperatures and climate forcing over the past 1000 years allow the warming of the 20th century to be placed within a historical context and various mechanisms of climate change to be tested. Comparisons of observations with simulations from an energy balance climate model indicate that as much as 41 to 64% of preanthropogenic (pre-1850) decadal-scale temperature variations was due to changes in solar irradiance and volcanism. Removal of the forced response from reconstructed temperature time series yields residuals that show similar variability to those of control runs of coupled models, thereby lending support to the models' value as estimates of low-frequency variability in the climate system. Removal of all forcing except greenhouse gases from the approximately 1000-year time series results in a residual with a very large late-20th-century warming that closely agrees with the response predicted from greenhouse gas forcing. The combination of a unique level of temperature increase in the late 20th century and improved constraints on the role of natural variability provides further evidence that the greenhouse effect has already established itself above the level of natural variability in the climate system. A 21st-century global warming projection far exceeds the natural variability of the past 1000 years and is greater than the best estimate of global temperature change for the last interglacial.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crowley -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):270-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oceanography, Texas A&M University, College Station, TX 77843, USA. E-mail: tcrowley@ocean.tamu.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10894770" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 17
    facet.materialart.
    Unknown
    VirB/D4-dependent protein translocation from Agrobacterium into plant cells (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-11-04
    Description: The Agrobacterium VirB/D4 transport system mediates the transfer of a nucleoprotein T complex into plant cells, leading to crown gall disease. In addition, several Virulence proteins must somehow be transported to fulfill a function in planta. Here, we used fusions between Cre recombinase and VirE2 or VirF to directly demonstrate protein translocation into plant cells. Transport of the proteins was monitored by a Cre-mediated in planta recombination event resulting in a selectable phenotype and depended on the VirB/D4 transport system but did not require transferred DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vergunst, A C -- Schrammeijer, B -- den Dulk-Ras, A -- de Vlaam, C M -- Regensburg-Tuink, T J -- Hooykaas, P J -- New York, N.Y. -- Science. 2000 Nov 3;290(5493):979-82.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Molecular Plant Sciences, Leiden University, Clusius Laboratory, Wassenaarseweg 64, 2333 AL, Leiden, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11062129" target="_blank"〉PubMed〈/a〉
    Keywords: Agrobacterium tumefaciens/genetics/*metabolism/pathogenicity ; Arabidopsis/genetics/*metabolism/microbiology ; Bacterial Proteins/*metabolism ; DNA, Bacterial/genetics/metabolism ; DNA-Binding Proteins/*metabolism ; Drug Resistance ; Integrases/genetics/*metabolism ; *Ion Channels ; Kanamycin/pharmacology ; Plant Roots/metabolism ; Plants, Genetically Modified ; Plasmids ; Polymerase Chain Reaction ; *Protein Transport ; Recombinant Fusion Proteins/metabolism ; *Viral Proteins ; Virulence ; *Virulence Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 18
    facet.materialart.
    Unknown
    Questioning evidence for recombination in human mitochondrial DNA (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parsons, T J -- Irwin, J A -- New York, N.Y. -- Science. 2000 Jun 16;288(5473):1931.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Armed Forces DNA Identification Laboratory, Armed Forces Institute of Pathology, 1413 Research Blvd., Rockville, MD 20886, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10877702" target="_blank"〉PubMed〈/a〉
    Keywords: DNA, Mitochondrial/*genetics ; Databases, Factual ; Ethnic Groups/genetics ; Humans ; Linkage Disequilibrium ; Mutation ; *Recombination, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 19
    facet.materialart.
    Unknown
    Bacterial recognition of mineral surfaces: nanoscale interactions between Shewanella and alpha-FeOOH (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-05-19
    Description: Force microscopy has been used to quantitatively measure the infinitesimal forces that characterize interactions between Shewanella oneidensis (a dissimilatory metal-reducing bacterium) and goethite (alpha-FeOOH), both commonly found in Earth near-surface environments. Force measurements with subnanonewton resolution were made in real time with living cells under aerobic and anaerobic solutions as a function of the distance, in nanometers, between a cell and the mineral surface. Energy values [in attojoules (10(-18) joules)] derived from these measurements show that the affinity between S. oneidensis and goethite rapidly increases by two to five times under anaerobic conditions in which electron transfer from bacterium to mineral is expected. Specific signatures in the force curves suggest that a 150-kilodalton putative iron reductase is mobilized within the outer membrane of S. oneidensis and specifically interacts with the goethite surface to facilitate the electron transfer process.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lower, S K -- Hochella, M F Jr -- Beveridge, T J -- New York, N.Y. -- Science. 2001 May 18;292(5520):1360-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉NanoGeoscience and Technology Laboratory, Department of Geological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. slower@vt.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11359008" target="_blank"〉PubMed〈/a〉
    Keywords: Aerobiosis ; Anaerobiosis ; *Bacterial Adhesion ; Electron Transport ; *FMN Reductase ; Geologic Sediments/chemistry/*microbiology ; Iron Compounds/chemistry/*metabolism ; *Microscopy, Atomic Force ; Minerals ; NADH, NADPH Oxidoreductases/metabolism ; Shewanella/enzymology/*metabolism ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 20
    facet.materialart.
    Unknown
    Application of the Marcus cross relation to hydrogen atom transfer reactions (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-26
    Description: The transfer of a hydrogen atom-a proton and an electron-is a fundamental process in chemistry and biology. A variety of hydrogen atom transfer reactions, involving iron complexes, phenols, hydroxylamines, tBuOOH, toluene, and related radicals, are shown to follow the Marcus cross relation. Thus, the Marcus theory formalism based on ground-state energetics and self-exchange rates, originally developed for electron transfer processes, is also valuable for hydrogen atom transfer. Compounds that undergo slow proton transfer (C-H bonds) or slow electron transfer (cobalt complexes) also undergo slow hydrogen atom transfer. Limitations of this approach are also discussed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, J P -- Yoder, J C -- Won, T J -- Mayer, J M -- 1 F32 GM63383-01/GM/NIGMS NIH HHS/ -- 2 R01 GM50422-05/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2001 Dec 21;294(5551):2524-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11752572" target="_blank"〉PubMed〈/a〉
    Keywords: Chemistry, Physical ; Cobalt/chemistry ; Cyclic N-Oxides/chemistry ; Electrons ; Ferric Compounds/chemistry ; Ferrous Compounds/chemistry ; Free Radicals ; Hydrogen/*chemistry ; Imidazoles/chemistry ; Kinetics ; Magnetic Resonance Spectroscopy ; Mathematics ; Oxidation-Reduction ; Physicochemical Phenomena ; Protons ; Pyrimidines/chemistry ; Thermodynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...