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  • Fusion energy  (2)
  • Key words. HIV-1; Tat; metastasis; TIP30; CC3.  (1)
  • Springer  (3)
  • 2000-2004  (3)
  • 1935-1939
  • 1930-1934
  • 1
    Electronic Resource
    Electronic Resource
    Technical Opportunities for International Collaborations by the U.S. Fusion Program (2000)
    Springer
    Journal of fusion energy 19 (2000), S. 65-79 
    Details
    ISSN: 1572-9591
    Keywords: Fusion energy ; international collaboration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This report was prepared by a Working Group at the request of the U.S. Department of Energy, Office of Fusion Energy Sciences in 1997. The report addresses technical opportunities for mutually beneficial collaboration between the United States and other international fusion research programs. A number of outstanding opportunities are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012281826821
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  • 2
    Electronic Resource
    Electronic Resource
    Report of the Integrated Program Planning Activity for the U.S. Department of Energy Fusion Energy Sciences Program (2000)
    Springer
    Journal of fusion energy 19 (2000), S. 169-228 
    Details
    ISSN: 1572-9591
    Keywords: Fusion energy ; fusion program planning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract This report of the Integrated Program Planning Activity (IPPA) has been prepared in response to a recommendation by the Secretary of Energy Advisory Board that, “Given the complex nature of the fusion effort, an integrated program planning process is an absolute necessity.” We therefore undertook this activity to integrate the various elements of the program, to improve communication and performance accountability across the program, and to show the interconnectedness and interdependency of the diverse parts of the national Fusion Energy Sciences Program. This report is based on the September 1999 Fusion Energy Sciences Advisory Committee's (FESAC) report “Priorities and Balance within the Fusion Energy Sciences Program.” In its December 5, 2000, letter to the Director of the Office of Science, the FESAC reaffirmed the validity of the September 1999 report and stated that the IPPA presents a framework and process to guide the achievement of the 5-year goals listed in the 1999 report. The report also outlines a process for establishing a database for the fusion research program that will indicate how each research element fits into the overall program. This database will also include near-term milestones associated with each research element and will facilitate assessments of the balance within the program at different levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015210800836
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  • 3
    Electronic Resource
    Electronic Resource
    Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression (2000)
    Springer
    Cellular and molecular life sciences 57 (2000), S. 851-858 
    Details
    ISSN: 1420-9071
    Keywords: Key words. HIV-1; Tat; metastasis; TIP30; CC3.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Human TIP30 is a cofactor that specifically enhances human immunodeficiency virus-1 (HIV-1) Tat-activated transcription. The sequence of TIP30 is identical to that of CC3, a protein associated with metastasis suppression. TIP30/CC3 is a member of the short-chain dehydrogenases/reductases (SDR) family. Of the several experimentally determined SDR structures, Escherichia coli uridine diphosphate (UDP) galactose-4 epimerase is most similar to TIP30/CC3. Because the direct sequence similarity between TIP30/CC3 and E. coli UDP galactose-4 epimerase is low, we used the transitive nature of homology and employed two Aquifex aeolicus proteins as intermediaries in the homology modeling process. Comparison of our structural model with that of known SDRs reveals that TIP30/CC3 contains several well-conserved features, including a βαβ fold at the amino terminus, which we predict binds NADP(H). TIP30/CC3 contains characteristic motifs at the catalytic site of SDRs, including a serine, tyrosine, and lysine that are important in catalyzing hydride transfer between substrate and cofactor. We also predict that a unique 20-amino acid sequence found at the amino terminus is an α-helix. Because this region contains several positively and negatively charged amino acids, it may dock TIP30/CC3 to other proteins. Our structural model points to this α-helix and the SDR-like part of TIP30/CC3 for mutagenesis experiments to elucidate its role in HIV-1 Tat-activated transcription, metastasis suppression, and other cellular functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000180050047
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