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  • Springer Nature  (14)
  • American Association for the Advancement of Science (AAAS)  (7)
  • Nature Publishing Group  (5)
  • 2000-2004  (23)
  • 1945-1949  (3)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Dominant and recessive deafness caused by mutations of a novel gene, TMC1 , required for cochlear hair-cell function (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 277-284 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Positional cloning of hereditary deafness genes is a direct approach to identify molecules and mechanisms underlying auditory function. Here we report a locus for dominant deafness, DFNA36, which maps to human chromosome 9q13–21 in a region overlapping the DFNB7/B11 locus for recessive ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng842
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  • 2
    Electronic Resource
    Electronic Resource
    Beethoven, a mouse model for dominant, progressive hearing loss DFNA36 (2002)
    [s.l.] : Nature Publishing Group
    Nature genetics 30 (2002), S. 257-258 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Despite recent progress in identifying genes underlying deafness, there are still relatively few mouse models of specific forms of human deafness. Here we describe the phenotype of the Beethoven (Bth) mouse mutant and a missense mutation in Tmc1 (transmembrane cochlear-expressed gene 1). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng848
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  • 3
    Electronic Resource
    Electronic Resource
    Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo (2003)
    [s.l.] : Nature Publishing Group
    Nature medicine 9 (2003), S. 357-362 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Small polybasic peptides derived from the transduction domains of certain proteins, such as the third α-helix of the Antennapedia (Antp) homeodomain, can cross the cell membrane through a receptor-independent mechanism. These cell-permeable molecules have been used as 'Trojan horses' to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm835
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  • 4
    Electronic Resource
    Electronic Resource
    Evolutionary biology (communication arising) Why do birds engage in extra-pair copulation? (2003)
    [s.l.] : Nature Publishing Group
    Nature 422 (2003), S. 833-833 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Female birds often copulate with males that are not their social partner, but why they do this is unclear. Blomqvist et al. present evidence from three wader species showing that extra-pair fertilizations are more likely when social mates are genetically closely related. We argue, however, that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/422833a
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  • 5
    Electronic Resource
    Electronic Resource
    Need for Development of Tropical Ecological Studies (1945)
    [s.l.] : Nature Publishing Group
    Nature 156 (1945), S. 627-628 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE development of the Colonies in respect of their plant resources should be at the present a matter of considerable importance, and anything which may hinder that development equally a matter of concern. As a result of numerous discussions between ourselves, and in the light of our varied ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/156627a0
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  • 6
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    Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2 (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-11-01
    Description: Mutations in MeCP2, which encodes a protein that has been proposed to function as a global transcriptional repressor, are the cause of Rett syndrome (RT T), an X-linked progressive neurological disorder. Although the selective inactivation of MeCP2 in neurons is sufficient to confer a Rett-like phenotype in mice, the specific functions of MeCP2 in postmitotic neurons are not known. We find that MeCP2 binds selectively to BDNF promoter III and functions to repress expression of the BDNF gene. Membrane depolarization triggers the calcium-dependent phosphorylation and release of MeCP2 from BDNF promoter III, thereby facilitating transcription. These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Wen G -- Chang, Qiang -- Lin, Yingxi -- Meissner, Alexander -- West, Anne E -- Griffith, Eric C -- Jaenisch, Rudolf -- Greenberg, Michael E -- HD 18655/HD/NICHD NIH HHS/ -- NS28829/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2003 Oct 31;302(5646):885-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Neuroscience, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14593183" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain-Derived Neurotrophic Factor/*genetics ; Calcium/*metabolism ; Cell Membrane/physiology ; Cells, Cultured ; *Chromosomal Proteins, Non-Histone ; Cloning, Molecular ; CpG Islands ; DNA Methylation ; DNA-Binding Proteins/*metabolism ; Electrophoretic Mobility Shift Assay ; *Gene Expression Regulation ; Gene Silencing ; Histones/metabolism ; Methyl-CpG-Binding Protein 2 ; Methylation ; Mice ; Mice, Knockout ; Neurons/metabolism/physiology ; Phosphorylation ; Potassium Chloride/pharmacology ; Precipitin Tests ; Promoter Regions, Genetic ; Rats ; *Repressor Proteins ; Rett Syndrome/genetics ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Detection of daily clouds on Titan (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-10-20
    Description: We have discovered frequent variations in the near-infrared spectrum of Titan, Saturn's largest moon, which are indicative of the daily presence of sparse clouds covering less than 1% of the area of the satellite. The thermodynamics of Titan's atmosphere and the clouds' altitudes suggest that convection governs their evolutions. Their short lives point to the presence of rain. We propose that Titan's atmosphere resembles Earth's, with clouds, rain, and an active weather cycle, driven by latent heat release from the primary condensible species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffith, C A -- Hall, J L -- Geballe, T R -- New York, N.Y. -- Science. 2000 Oct 20;290(5491):509-13.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, Northern Arizona University, Flagstaff, AZ 86011-6010, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11039930" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; *Extraterrestrial Environment ; Methane ; Rain ; *Saturn ; Spectrum Analysis ; Sunlight ; Temperature ; Thermodynamics ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-07
    Description: The Golgi-localized, gamma-ear-containing, adenosine diphosphate ribosylation factor-binding proteins (GGAs) are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) in the Golgi and have an essential role in lysosomal enzyme sorting. Here the GGAs and the coat protein adaptor protein-1 (AP-1) were shown to colocalize in clathrin-coated buds of the trans-Golgi networks of mouse L cells and human HeLa cells. Binding studies revealed a direct interaction between the hinge domains of the GGAs and the gamma-ear domain of AP-1. Further, AP-1 contained bound casein kinase-2 that phosphorylated GGA1 and GGA3, thereby causing autoinhibition. This could induce the directed transfer of the MPRs from GGAs to AP-1. MPRs that are defective in binding to GGAs are poorly incorporated into AP-1-containing clathrin-coated vesicles. Thus, the GGAs and AP-1 interact to package MPRs into AP-1-containing coated vesicles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Doray, Balraj -- Ghosh, Pradipta -- Griffith, Janice -- Geuze, Hans J -- Kornfeld, Stuart -- R01 CA-08759/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 6;297(5587):1700-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12215646" target="_blank"〉PubMed〈/a〉
    Keywords: ADP-Ribosylation Factors/*metabolism ; Adaptor Proteins, Vesicular Transport ; Animals ; Biological Transport ; Carrier Proteins/*metabolism ; Cattle ; Cell Line ; Clathrin-Coated Vesicles/metabolism ; HeLa Cells ; Humans ; L Cells (Cell Line) ; Membrane Proteins/*metabolism ; Mice ; Mutation ; Phosphorylation ; Protein Binding ; Receptor, IGF Type 2/genetics/*metabolism ; Recombinant Proteins/metabolism ; trans-Golgi Network/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Tissue engineering--current challenges and expanding opportunities (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-02-09
    Description: Tissue engineering can be used to restore, maintain, or enhance tissues and organs. The potential impact of this field, however, is far broader-in the future, engineered tissues could reduce the need for organ replacement, and could greatly accelerate the development of new drugs that may cure patients, eliminating the need for organ transplants altogether.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffith, Linda G -- Naughton, Gail -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1009-14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemical Engineering, Division of Bioengineering and Environmental Health, and Biotechnology Process Engineering Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. griff@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834815" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biocompatible Materials ; Bioreactors ; Blood Vessels/physiology ; Cell Culture Techniques ; Cell Differentiation ; Culture Techniques ; Embryo, Mammalian/cytology ; Humans ; Models, Biological ; Neovascularization, Physiologic ; Skin Transplantation ; Stem Cells/physiology ; *Tissue Engineering/instrumentation/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Evidence for the exposure of water ice on Titan's surface (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-04-26
    Description: The smoggy stratosphere of Saturn's largest moon, Titan, veils its surface from view, except at narrow wavelengths centered at 0.83, 0.94, 1.07, 1.28, 1.58, 2.0, 2.9, and 5.0 micrometers. We derived a spectrum of Titan's surface within these "windows" and detected features characteristic of water ice. Therefore, despite the hundreds of meters of organic liquids and solids hypothesized to exist on Titan's surface, its icy bedrock lies extensively exposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffith, Caitlin A -- Owen, Tobias -- Geballe, Thomas R -- Rayner, John -- Rannou, Pascal -- New York, N.Y. -- Science. 2003 Apr 25;300(5619):628-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Planetary Sciences, University of Arizona, 1629 East University Boulevard, Tucson, AZ 85721-0092, USA. griffith@lpl.arizona.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12714742" target="_blank"〉PubMed〈/a〉
    Keywords: Atmosphere ; Carbon Monoxide ; Extraterrestrial Environment ; *Ice ; Methane ; Organic Chemicals ; *Saturn ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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