Publication Date:
2003-06-07
Description:
The basic molecular mechanisms underlying circadian oscillators follow the same general plan across the phylogenetic spectrum: oscillating feedback loops in which clock gene products negatively regulate their own expression. The circadian clocks of animals involve at least two interacting feedback loops. This Viewpoint compares and contrasts the circadian clocks of mammals and of Drosophila, emphasizing how different players are used to create the same basic script. Both the general script and the specific details of the murine and Drosophila circadian pathways are available at Science's Signal Transduction Knowledge Environment Connections Maps.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Gelder, Russell N -- Herzog, Erik D -- Schwartz, William J -- Taghert, Paul H -- New York, N.Y. -- Science. 2003 Jun 6;300(5625):1534-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Ophthalmology and Visual Sciences, Washington University, St. Louis, MO 63110, USA. vangelder@vision.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12791982" target="_blank"〉PubMed〈/a〉
Keywords:
ARNTL Transcription Factors
;
Animals
;
Basic Helix-Loop-Helix Transcription Factors
;
*Biological Clocks
;
CLOCK Proteins
;
*Circadian Rhythm
;
Cryptochromes
;
Drosophila/genetics/*physiology
;
*Drosophila Proteins
;
*Eye Proteins
;
*Feedback, Physiological
;
Flavoproteins/metabolism
;
Gene Expression Regulation
;
Light
;
Mice
;
Nuclear Proteins/genetics/metabolism
;
Period Circadian Proteins
;
*Photoreceptor Cells, Invertebrate
;
Receptors, G-Protein-Coupled
;
*Signal Transduction
;
Suprachiasmatic Nucleus/physiology
;
Trans-Activators/genetics/metabolism
;
Transcription Factors/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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