Publication Date:
2001-05-12
Description:
T cell activation is dependent on both a primary signal delivered through the T cell receptor and a secondary costimulatory signal mediated by coreceptors. Although controversial, costimulation is thought to act through the specific redistribution and clustering of membrane and intracellular kinase-rich lipid raft microdomains at the contact site between T cells and antigen-presenting cells. This site has been termed the immunological synapse. Endogenous mediators of raft clustering in lymphocytes have not been identified, although they are essential for T cell activation. We now demonstrate that agrin, an aggregating protein crucial for formation of the neuromuscular junction, is also expressed in lymphocytes and is important in reorganization of membrane lipid microdomains and setting the threshold for T cell signaling. Our data show that agrin induces the aggregation of signaling proteins and the creation of signaling domains in both immune and nervous systems through a common lipid raft pathway.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Khan, A A -- Bose, C -- Yam, L S -- Soloski, M J -- Rupp, F -- R01AI20922/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Jun 1;292(5522):1681-6. Epub 2001 May 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Outer Banks Neuroscience, Baltimore, MD 21218, USA. outerbanksneuro@yahoo.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11349136" target="_blank"〉PubMed〈/a〉
Keywords:
Agrin/genetics/metabolism/*physiology
;
Alternative Splicing
;
Animals
;
Antigen-Presenting Cells/immunology/*physiology
;
B-Lymphocytes/metabolism
;
Glycosylation
;
*Lymphocyte Activation
;
Male
;
Membrane Microdomains/*physiology
;
Mice
;
Neuromuscular Junction/physiology
;
Neurons/physiology
;
Rats
;
Rats, Sprague-Dawley
;
Receptor Aggregation
;
Receptors, Antigen, T-Cell/physiology
;
Receptors, Cholinergic/physiology
;
Signal Transduction
;
T-Lymphocyte Subsets/metabolism
;
T-Lymphocytes/immunology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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