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  • 1
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2002-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ingolia, Nicholas T -- Murray, Andrew W -- New York, N.Y. -- Science. 2002 Aug 9;297(5583):948-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology and Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12169717" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Biological Evolution ; *Cell Cycle Proteins ; Cells, Cultured ; Dual Specificity Phosphatase 1 ; *Feedback, Physiological ; Immediate-Early Proteins/*metabolism ; *MAP Kinase Signaling System ; Mitogen-Activated Protein Kinases/*metabolism ; Models, Biological ; *Phosphoprotein Phosphatases ; Platelet-Derived Growth Factor/metabolism/pharmacology ; Protein Phosphatase 1 ; Protein Tyrosine Phosphatases/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2000-07-15
    Description: The spindle checkpoint was characterized in meiosis of budding yeast. In the absence of the checkpoint, the frequency of meiosis I missegregation increased with increasing chromosome length, reaching 19% for the longest chromosome. Meiosis I nondisjunction in spindle checkpoint mutants could be prevented by delaying the onset of anaphase. In a recombination-defective mutant (spo11Delta), the checkpoint delays the biochemical events of anaphase I, suggesting that chromosomes that are attached to microtubules but are not under tension can activate the spindle checkpoint. Spindle checkpoint mutants reduce the accuracy of chromosome segregation in meiosis I much more than that in meiosis II, suggesting that checkpoint defects may contribute to Down syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shonn, M A -- McCarroll, R -- Murray, A W -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10894778" target="_blank"〉PubMed〈/a〉
    Keywords: Biomechanical Phenomena ; Chromosome Segregation/*physiology ; Chromosomes, Fungal ; Down Syndrome/genetics ; Endodeoxyribonucleases ; Esterases/genetics ; Kinetochores/physiology ; Meiosis/genetics/*physiology ; Mutation ; Nondisjunction, Genetic ; Recombination, Genetic ; Saccharomycetales/genetics/*physiology ; Spindle Apparatus/*physiology ; Spores, Fungal
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2001-03-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, A W -- New York, N.Y. -- Science. 2001 Feb 23;291(5508):1499-502.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. amurray@mcb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11234079" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Cell Cycle ; *Cell Division ; Cell Line ; Cells, Cultured ; Centrioles/*physiology ; Centrosome/*physiology ; Chromosome Segregation ; DNA Replication ; Microtubules/physiology ; Mitosis ; Proteins/physiology ; Saccharomycetales/cytology/physiology ; Spindle Apparatus/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 57 (2000), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The absolute gut evacuation rate (GER) (g day−1) of Harpagifer antarcticus increased with increasing ration mass, fish mass only influenced the absolute GER at a daily ration level of 0·3% wet fish mass (approximately a maintenance ration). The relative GER (% of meal fed day−1) was also affected differently by fish and ration mass depending on the relative ration level being fed; at rations of 0·7% wet fish mass or above the relative GER decreased with increasing fish or ration mass (in such a way that the absolute GER remained constant and unaffected by fish mass). At maintenance (0·3% wet fish mass) rations the relative GER was not affected by fish size or ration mass. Thus, there appears to be a ration threshold above which the digestion physiology alters. Mass-specific GER (% g fish−1 day−1) decreased with increasing fish mass. Within a set relative ration level (% wet fish mass) an increase in fish mass decreased the mass-specific GER. At a fixed ration mass, an increase in fish mass (i.e. a reduction in the ration expressed as % fish mass) resulted in a decrease in mass-specific GER. Gut evaluation time (GET) decreased and absorption efficiency (A) increased with increasing absolute GER. The effect of ration and fish mass on the absolute and relative GER followed the same pattern irrespective of the diet, however the A and GER (% day−1 and g day−1) were higher and the GET shorter when the fish were fed shelled krill rather than amphipods.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Global change biology 8 (2002), S. 0 
    ISSN: 1365-2486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: We report a study which measured changes to the radiative environment arising from stratospheric O3 depletion at Rothera Point on the western Antarctic Peninsula (67°S, 68°W) and subsequent associations between these changes and the pigmentation and maximum quantum yield of photochemistry (Fv/Fm) of two Antarctic bryophytes, the liverwort Cephaloziella varians and the moss Sanionia uncinata. We found a strong relationship between O3 column depth and the ratio of UV-B to PAR irradiance (FUV-B/FPAR) recorded at ground level. Weaker, but significant, associations were also found between O3 column depth and noon irradiances and daily doses of unweighted and biologically effective UV-B radiation received at ground level. Regression analyses indicated that FUV-B/FPAR and daily dose of unweighted UV-B were best predictors for concentrations of total carotenoids and UV-B screening pigments extracted from bryophyte tissues. Concentrations of these pigments were loosely but significantly positively associated with O3-dependent irradiance parameters. HPLC analyses of carotenoids also suggested that both species increased the synthesis of neoxanthin during periods of O3 depletion. Violaxanthin, lutein, zeaxanthin and b,bββ-carotene concentrations were also apparently influenced by O3 reduction, but not consistently across both bryophyte species. Concentrations of chlorophylls a and b were apparently unaffected by O3 depletion.No direct associations between Fv/Fm and O3-dependent irradiance parameters were found. However stepwise multiple regression analyses suggested that the production of UV-B screening pigments conferred protection from elevated FUV-B/FPAR on Fv/Fm in both species and that carotenoids conferred protection on Fv/Fm in Sanionia. Our data suggest that changes to the radiative environment associated with stratospheric O3 depletion influence the pigmentation of two Antarctic bryophytes, but that Fv/Fm is unaffected, at least in part because of rapid synthesis of protective pigments.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 34 (1978), S. 691-691 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Topical application of the tumour promoter 12-0-tetradecanoyl-phorbol-13-acetate to skin caused a marked enhancement of mitotic acitivity both in mice maintained on a complete diet or on a vitamin B6-deficient diet.
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  • 7
    ISSN: 1432-2056
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Shell growth in Yoldia eightsi was measured over an austral summer and winter in 1992. In specimens 〈 12 mm length, growth was not significantly different between summer and winter periods, and the fastest recorded rate, 6.3 μm day−1 was for 5-mm individuals during the winter. In summer, specimens of all lengths grew significantly, but in winter bivalves 〉 27 mm length did not increase in length. Tissue dry and ash-free dry mass (AFDM) cycles were assessed at monthly intervals between December 1988 and January 1991. ANCOVA indicated significant interannual and seasonal effects on this cycle. Tissue mass increased in the summer, coinciding with the phytoplankton bloom and the period of maximum sedimentation of organic material from the water column. A standard 20-mm-length animal reached a maximum AFDM of 114 mg in February 1990. The minimum value (68 mg AFDM) throughout the 2 years of measurements was in early December 1988, at the end of the austral winter. Periods of tissue mass increase were, therefore, decoupled from shell growth, at least in juveniles. Tissue mass was significantly higher in 1990 than 1989, which was mainly due to high organic contents in the summer (January to May). This was not consistent with the pattern of organic content in the sediments at the study site, but was in phase with the cycle in sediment chlorophyll a content. Tissue mass increase depended on major resource input during the summer, but Y. eightsi was capable of maintaining winter condition from stocks of benthic microalgae in years of poor ice cover. Tissue mass declined between April and July each year. This was accompanied by large falls in tissue ash content, and coincided with the spawning period in early June. These are the first monthly tissue mass data collected over a 2-year period for an Antarctic mollusc. They are the first such data indicating seasonal variation in tissue mass and showing a decoupling of shell and tissue growth in a polar bivalve. The P/B ratio calculated from these data was 0.106, which is slightly lower than previous values found for this species, but is in line with general values for Antarctic marine benthos.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 34 (1978), S. 1507-1508 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mouse skin initiated with 7,12-dimethylbenz(a)anthracene and then exposed to multiple treatments of acetic acid, shows a decreased papilloma yield on subsequent promotion with croton oil.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 1978-06-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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  • 10
    Publication Date: 1978-11-01
    Print ISSN: 0014-4754
    Topics: Biology , Medicine
    Published by Springer
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