ISSN:
1573-4986
Keywords:
glycoside cluster effect
;
multi-valent interaction
;
C-type lectins
;
affinity enhancement
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The binding of simple carbohydrate ligands by proteins often requires affinity enhancement to attain biologically relevant strength. This is especially true for endocytotic receptors and the molecules that engage in the first-line of defense. For such purposes, nature often utilizes a mode of affinity enhancement that arises from multiple interactions between the binding proteins and the carbohydrate ligands, which we term glycoside cluster effect. In this review article we give a number of examples and describe important factors in the multi-valent interactions that govern the degree of affinity enhancement.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1011070425430
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