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  • Articles  (3)
  • particle size  (2)
  • 42.55
  • Bone
  • Coleoptera
  • Springer  (3)
  • Annual Reviews
  • Springer Science + Business Media
  • 2000-2004  (2)
  • 1980-1984  (1)
  • Technology  (3)
  • 1
    Electronic Resource
    Electronic Resource
    White-light Detection for Nanoparticle Sizing with the TSI Ultrafine Condensation Particle Counter (2000)
    Springer
    Journal of nanoparticle research 2 (2000), S. 85-90 
    Details
    ISSN: 1572-896X
    Keywords: nanoparticles ; pulse height analysis ; aerosol ; particle size ; condensation particle counter ; light scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract Several of the most common methods for measuring nanoparticle size distributions employ the ultrafine condensation particle counter (UCPC) for detection purposes. Among these methods, the pulse height analysis (PHA) technique, in which the optical response of the UCPC detector is related to initial particle diameter in the 3–10 nm range, prevails in applications where fast sampling is required or for which concentrations of nanoparticles are frequently very low. With the PHA technique, white light is required for particle illumination in order to obtain a monotonic relationship between initial particle diameter and optical response (pulse height). However, the popular, commercially available TSI Model 3025A UCPC employs a laser for particle detection. Here, we report on a novel white-light detection system developed for the 3025A UCPC that involves minimal alteration to the instrument and preserves normal counting operation. Performance is illustrated with pulse height spectra produced by differential mobility analyzer (DMA) – generated calibration aerosols in the 3–50 nm range.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010042604201
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  • 2
    Electronic Resource
    Electronic Resource
    Optimization of Preparation Techniques for Poly(Lactic Acid-Co-Glycolic Acid) Nanoparticles (2000)
    Springer
    Journal of nanoparticle research 2 (2000), S. 173-181 
    Details
    ISSN: 1572-896X
    Keywords: biodegradable ; poly(lactic acid-co-glycolic acid) ; drug delivery ; particle size ; aggregation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics , Technology
    Notes: Abstract Microparticles and nanoparticles of poly(lactic acid-co-glycolic acid) (PLAGA) are excellent candidates for the controlled release of many pharmaceutical compounds because of their biodegradable nature. The preparation of submicron PLAGA particles poses serious challenges that are not necessarily present when preparing microparticles. We have evaluated several combinations of organic solvents and surfactants used in the formulation of PLAGA nanoparticles. Critical factors such as the ability to separate the nanoparticles from the surfactant, the ability to re-suspend the nanoparticles after freeze-drying, formulation yield and nanoparticle size were studied. The smallest particles were obtained using the surfactant/solvent combination of sodium dodecyl sulfate and ethyl acetate (65 nm) and the largest particles were obtained using poly(vinyl alcohol) and dichloromethane (466 nm). However, the optimal nanoparticles were produced using either acetone or ethyl acetate as the organic solvent and poly(vinyl alcohol) or human serum albumin as the surfactant. This is because the most critical measure of performance of these nanoparticles proved to be their ability to re-suspend after freeze-drying.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1010038908767
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  • 3
    Electronic Resource
    Electronic Resource
    The human tibia: Static testing in bending by anin vivo method (1982)
    Springer
    Annals of biomedical engineering 10 (1982), S. 281-294 
    Details
    ISSN: 1573-9686
    Keywords: Tibia ; Strength ; Bone ; Elastic modulus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract We have developed a method for static testing of the human tibia in bending in the living subject, and fabricated a prototype device for carrying it out. Model testing indicates that the device and model system are inherently accurate and reliable. However, the biological system is more complex, and while more than 200 tests have been conducted with perfect safety, the variability of replicate tests suggests that the method does not yet have general clinical utility. In some subjects, that variance is relatively small, possibly because they are more relaxed and perhaps also for anatomical reasons. In two subjects, postmortem tests corresponded very well with antemortem tests on the tibiometer. We conclude that with further refinements the method may have clinical potential, if only in carefully selected subjects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02367309
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