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  • Articles  (38)
  • Springer  (16)
  • Elsevier  (12)
  • American Association for the Advancement of Science (AAAS)  (9)
  • Oxford University Press  (1)
  • American Institute of Physics (AIP)
  • 2000-2004  (20)
  • 1980-1984  (18)
  • 1950-1954
  • 1850-1859
  • Medicine  (38)
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  • Articles  (38)
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  • 1
    Electronic Resource
    Electronic Resource
    Alterations in the fraction of oxygen in inspired gas affect rates of renal prostaglandin E2 synthesis in anesthetized dogs (1981)
    Springer
    Cellular and molecular life sciences 37 (1981), S. 1293-1294 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Reductions of oxygen in inspired gas from 20% to 15%, in anesthetized dogs, reduced arterial PO2 and increased the renal efflux of PGE2 but not PGF2a . Renal blood flow, blood pressure, plasma renin activity as well as arterial pH and PCO2 were unaffected. PGs may mediate the renal hemodynamic or excretory consequences of alterations in PO2. In addition, minor variations in PO2 might account, in part, for the variable renal venous PGE2 concentrations reported under basal conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01948368
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of water hardness, water temperature, and size of the test organism on the susceptibility of the freshwater shrimp,Gammarus pulex (L.), to toxicants (1983)
    Springer
    Bulletin of environmental contamination and toxicology 31 (1983), S. 459-466 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01622278
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  • 3
    Electronic Resource
    Electronic Resource
    Persistence and effects of chemicals in small enclosures in ponds (1984)
    Springer
    Archives of environmental contamination and toxicology 13 (1984), S. 313-326 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract The use of small (1 m3) enclosures for providing data on the persistence and effects of chemicals in freshwater was investigated. The enclosures included an intact water column with its associated flora and fauna and provided water/air and water/sediment interfaces when placed in small ponds. The enclosures provided a means of examining a variety of toxic effects of two chemicals, an insecticide (methyl parathion) and a herbicide (linuron), under relatively natural conditions in a replicated experiment which lasted six weeks. Toxic effects on Zooplankton, macroinvertebrates, and the flora of the enclosures were observed and compared with the results of laboratory toxicity tests and bioassays of water samples collected from the enclosures. The persistence of the two chemicals in the water in the enclosures was followed by chemical analysis and bioassay. Experiments in enclosures could play a role in providing data to be used in the assessment of the hazard posed by chemicals: particularly in cases where the laboratory data on acute toxicity, to single species or simple associations of species, and knowledge of simple physical constants are inadequate to allow assessment of the hazard.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01055282
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  • 4
    Electronic Resource
    Electronic Resource
    Histone genes are located at the sphere loci of newt lampbrush chromosomes (1981)
    Springer
    Chromosoma 84 (1981), S. 159-171 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In situ hybridization experiments on mitotic and lampbrush chromosomes show that histone genes and an associated 222 bp repeated sequence, satellite 1, are located at or near the sphere loci of chromosomes 2 and 6 of the newt Notophthalmus viridescens. During the lampbrush chromosome stage, transcripts of the histone genes and of satellite 1 occur on loops associated with the spheres. Histone genes are located at sites on the mitotic chromosomes of Triturus cristatus and T. alpestris which are consistent with the known positions of spheres on their lampbrush chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399128
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  • 5
    Electronic Resource
    Electronic Resource
    Intracellular calcium during fatigue of cane toad skeletal muscle in the absence of glucose (2000)
    Springer
    Journal of muscle research and cell motility 21 (2000), S. 481-489 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Mechanisms of fatigue were studied in single muscle fibres of the cane toad (Bufo marinus) in which force, intracellular calcium ([Ca2+]i), [Mg2+]i, glycogen and the rapidly releasable Ca2+ from the sarcoplasmic reticulum (SR) were measured. Fatigue was produced by repeated tetani continued until force had fallen to 50%. Two patterns of fatigue in the absence of glucose were studied. In the first fatigue run force fell to 50% in 8–10 min. Fatigue runs were then repeated until force fell to 50% in 〈3 min in the final fatigue run. Addition of extracellular glucose after the final fatigue run prolonged a subsequent fatigue run. In the first fatigue run peak tetanic [Ca2+]i initially increased and then declined and at the time when force had fallen to 50% tetanic [Ca2+]i was 54 ± 5% of initial value. In the final fatigue run force and peak tetanic [Ca2+]i declined more rapidly but to the same level as in first fatigue runs. At the end of the first fatigue run, the rapidly releasable SR Ca2+ store fell to 46 ± 6% of the pre-fatigue value. At the end of the final fatigue run the rapidly releasable SR Ca2+ store was 109 ± 16% of the pre-fatigue value. In unstimulated fibres the nonwashable glycogen content was 176 ± 30 mmol glycosyl units/l fibre. After one fatigue run the glycogen content was 117 ± 17 mmol glycosyl units/l fibre; at the end of the final fatigue run the glycogen content was reduced to 85 ± 9 mmol glycosyl units/l fibre. [Mg2+]i did not change significantly at the end of fatigue in either the first or the final fatigue run suggesting that globally-averaged ATP does not decline substantially in either pattern of fatigue. These results suggest that different mechanisms are involved in the decline of tetanic [Ca2+]i in first compared to final fatigue runs. The SR Ca2+ store is reduced in first fatigue runs; this is not the case for the final fatigue run which is associated with a decline in glycogen and possibly related to either a non-metabolic effect of glycogen or a spatially-localised metabolic decline.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005650425513
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  • 6
    Electronic Resource
    Electronic Resource
    Glycogen stability and glycogen phosphorylase activities in isolated skeletal muscles from rat and toad (2000)
    Springer
    Journal of muscle research and cell motility 21 (2000), S. 655-662 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract There is increasing evidence that endogenous glycogen depletion may affect excitation–contraction (E–C) coupling events in vertebrate skeletal muscle. One approach employed in physiological investigations of E–C coupling involves the use of mechanically skinned, single fibre preparations obtained from tissues stored under paraffin oil, at room temperature (RT: 20–24°C) and 4°C for several hours. In the present study, we examined the effect of these storage conditions on the glycogen content in three muscles frequently used in research on E–C coupling: rat extensor digitorum longus (EDL) and soleus (SOL) and toad iliofibularis (IF). Glycogen content was determined fluorometrically in homogenates prepared from whole muscles, stored under paraffin oil for up to 6 h at RT or 4°C. Control muscles and muscles stored for 0.5 and 6 h were also analysed for total phosphorylase (Phostotal) and phosphorylase a (Phos a) activities. No significant change was observed in the glycogen content of EDL and SOL muscles stored at RT for 0.5 h. In rat muscles stored at RT for longer than 0.5 h, the glycogen content decreased to 67.6% (EDL) and 78.7% (SOL) of controls after 3 h and 25.3% (EDL) and 37.4% (SOL) after 6 h. Rat muscles stored at 4°C retained 79.0% (EDL) and 92.5% (SOL) of glycogen after 3 h and 75.2% (EDL) and 61.1% (SOL) after 6 h. The glycogen content of IF muscles stored at RT or 4°C for 6 h was not significantly different from controls. Phostotal was unchanged in all muscles over the 6 h period, at both temperatures. Phos a was also unchanged in the toad IF muscles, but in rat muscles it decreased rapidly, particularly in EDL (4.1-fold after 0.5 h at RT). Taken together these results indicate that storage under paraffin oil for up to 6 h at RT or 4°C is accompanied by minimal glycogen loss in toad IF muscles and by a time- and temperature-dependent glycogen loss in EDL and SOL muscles of the rat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005628500892
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  • 7
    Electronic Resource
    Electronic Resource
    Activation of skinned arthropod muscle fibres by Ca2+ and Sr2+ (1980)
    Springer
    Journal of muscle research and cell motility 1 (1980), S. 73-87 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Mechanically skinned skeletal muscle fibres of three crustaceans (barnacle, crayfish and crab) and two insects (cockroach and cricket) were activated in Ca2+- and Sr2+-buffered solutions of different concentrations and the isometric force response was determined. The maximum force response induced by Sr2+ (P 0 Sr ) was only 0–10% of that induced by Ca2+ (P 0 Ca ) in all crustacean muscles, but approached 90% in insects. Experiments on barnacle muscle fibres activated simultaneously by Ca2+ and Sr2+ suggested that Sr2+ competes with Ca2+ for binding onto the regulatory sites without, however, being able to turn all of them ‘on’ as efficiently as Ca2+. Interestingly, the ratioP 0 Sr /P 0 Ca and the sensitivity for both Sr2+ and Ca2+ increased substantially after 4–6 h following the dissection of the animals in most intact decapod muscle fibres and after 24 h in most barnacle muscle fibres. The steepness of the activation curves for both Ca2+ and Sr2+ was similar for each muscle regardless of the age of the fibre and implied that more than 2 Ca2+ (2 Sr2+) were involved in the activation process of each muscle. A Ca2+-induced Ca2+ release mechanism of physiological importance was found to operate in all arthropod muscle fibres investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711926
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  • 8
    Electronic Resource
    Electronic Resource
    Length dependence of changes in sarcoplasmic calcium concentration and myofibrillar calcium sensitivity in striated muscle fibres (1984)
    Springer
    Journal of muscle research and cell motility 5 (1984), S. 243-272 
    Details
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713107
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  • 9
    Electronic Resource
    Electronic Resource
    Assessing the conditions forin vivo electrical virtual biopsies in Barrett's oesophagus (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 373-376 
    Details
    ISSN: 1741-0444
    Keywords: Virtual biopsies ; Barrett's oesophagus ; Bio-electrical impedance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract It has previously been shown that it is possible to differentiate between squamous and columnar epithelia in rat and resected human tissues using an impedance probe to makein vitro measurements. This probe can be passed down an endoscope allowing measurements to be made in patients. However, the probe emerges parallel to the oesophageal wall, with little room to manoeuvre. The conditions of control required to give reliable readings have been investigated. The importance of pressure applied and the angle of approach to the oesophagus was assessed. Pressures in the range 26.6 Pa to 46.3 kPa and angles in the range 15–90 degrees were considered. Inin vitro studies it was observed that it was possible to obtain consistent readings with pressures greater than 2.9 kPa and with angles greater than 15 degrees between the probe and the oesophagus. These conditions can be achievedin vivo, and readings obtained from twelve patients are shown (45 readings on normal squamous, 34 on Barrett's oesophagus and 22 on stomach). At low frequencies (9.6–153.2 kHz), a Mann-Whitney test shows a significant difference (p〈0.001) when comparing the means from squamous and columnar, and also when readings from Barrett's and normal gastric epithelia are compared (p〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02345004
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  • 10
    Electronic Resource
    Electronic Resource
    Co-segregation of elevated LDL with a novel mutation (D92K) of the LDL receptor in a kindred with multiple lipoprotein abnormalities (2000)
    Springer
    Journal of human genetics 45 (2000), S. 154-158 
    Details
    ISSN: 1435-232X
    Keywords: Key words Hyperlipoproteinemia ; Lipoproteins ; LDL receptor ; Familial combined hyperlipidemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Factors predisposing to the phenotypic features of familial combined hyperlipidemia have not been clearly defined. In the course of investigating familial coronary artery disease in Utah, we identified a three-generation family in which multiple members were affected with type IIa hyperlipoproteinemia (HLP IIa), type IIb hyperlipoproteinemia (HLP IIb), or type IV hyperlipoproteinemia (HLP IV). Because several family members had relatively severe low-density lipoprotein (LDL) cholesterol elevation, in order to dissect the possible contribution to the plasma lipoprotein abnormalities in this pedigree, we identified a novel point mutation in the low-density lipoprotein receptor (LDLR) gene, a G-to-A transition at nucleotide position 337 in exon 4. This change substituted lysine for glutamic acid at codon 92 (D92K) of the LDL receptor. By means of mutant allele-specific amplification we determined that the mutation co-segregated with elevated cholesterol and LDL cholesterol in the plasma of family members with HLP IIa and HLP IIb, but not with the elevated plasma triglycerides seen in HLP IIb and HLP IV patients. Thus, in families with apparent familial combined hyperlipidemia, a defective LDLR allele and other genetic or environmental factors that elevate plasma triglycerides may account for the multiple lipid phenotypes observed in this kindred.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s100380050202
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