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  • nitrogen  (54)
  • drug interaction  (48)
  • Springer  (102)
  • American Chemical Society
  • Elsevier
  • 2000-2004  (12)
  • 1985-1989  (90)
Collection
Keywords
Publisher
  • Springer  (102)
  • American Chemical Society
  • Elsevier
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Theophylline intoxication following viloxazine induced decrease in clearance (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 351-353 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; viloxazine ; clearance ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A case is reported of theophylline intoxication due to a dramatic decrease in theophylline clearance following concomitant administration of viloxazine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541543
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  • 2
    Electronic Resource
    Electronic Resource
    Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 371-374 
    Details
    ISSN: 1432-1041
    Keywords: oxaprozin ; drug interaction ; acetaminophen ; cimetidine ; ranitidine ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twelve healthy male volunteers participated in a single-dose four-way crossover study to evaluate potential drug interactions with oxaprozin, a nonsteroidal antiinflammatory agent of the propionic class. The four modes of administration were:a. oxaprozin, 1200 mg alone;b. oxaprozin during concurrent acetaminophen, 500 mg 4 times daily;c. oxaprozin with cimetidine, 300 mg 4 times daily;d. oxaprozin with ranitidine, 150 mg every 12 hours. Acetaminophen, cimetidine, or ranitidine were begun 24 hours prior to oxaprozin dosage and continued for the 10-day duration of each trial. No significant differences existed among the four treatment conditions in peak plasma oxaprozin concentration (86 µg/ml), volume of distribution (0.23 l/kg), time of peak concentration (3.7 h after dosage), or elimination half-life (54 h). Oxaprozin oral clearance was significantly lower (by 20%) during both the cimetidine and ranitidine trials versus control (0.047 vs 0.047 vs 0.059 ml/min/kg), but clearance during acetaminophen was not significantly different from control. Thus acetaminophen, cimetidine or ranitidine has only a small influence on the pharmacokinetics of a single oral dose of oxaprozin. The reduction in oxaprozin clearance due to cimetidine or ranitidine is statistically significant but small in magnitude.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981141
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of Septic Effluent for Fecal Coliform and Nitrogen in Coarse-textured Soils: Use of Soil-only and Sand Filter Systems (2000)
    Springer
    Water, air & soil pollution 124 (2000), S. 205-215 
    Details
    ISSN: 1573-2932
    Keywords: on-site treatment ; fecal coliform bacteria ; nitrate leaching ; nitrogen ; on-site treatment ; septic effluent
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract Groundwater effluent sample collectors(zero-tension lysimeters) were installed directlybelow the drainfields of three residential onsitetreatment systems in the Clover/Chambers Creek aquiferregion of Pierce County near Tacoma, WA. The use of asplit effluent delivery system from the septic tank,where half the effluent was delivered under pressureto a normal native soil-only filter system and halfwas delivered to a sand filter system, allowed thedirect comparison of the two commonly-utilized septicsystems for treatment levels. Septic tank effluent(from the septic tank) and percolating water (between0.3 and 0.9 m beneath the effluent distributionlines) was collected between May 1991 and April 1994on 30 occasions. Samples were analyzed for fecalcoliform bacteria, nitrate, nitrite, ammonium andtotal reduced (Kjeldahl) nitrogen. Results of thisstudy indicate that the use of sand filters greatlyincreased removal of fecal coliform bacteria and totalnitrogen. Soil-only filter systems had an average of91% removal of fecal coliforms and 47%of total N; whereas sand filter systems had an averageof 99.8% removal of fecal coliforms and 80% of total N.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005298932244
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  • 4
    Electronic Resource
    Electronic Resource
    Survival of the Colorado potato beetle on virus-infected tomato in relation to plant nitrogen and alkaloid content (1987)
    Springer
    Entomologia experimentalis et applicata 44 (1987), S. 31-35 
    Details
    ISSN: 1570-7458
    Keywords: host quality ; nitrogen ; survival ; Leptinotarsa decemlineata ; Lycopersicon esculentum ; plant virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Pour vérifier l'hypothèse selon laquelle une contamination par un virs végétal peut accroître la consommation de plantes délaissées ou partiellement résistantes, nous avons examiné les interactions entre Leptinotarsa decemlineata Say, Lycopersicon esculentum Mill., et le virus de la mosaïque du tabac (TMV). La survie des larves de L. decemlineata a augmenté avec la contamination par TMV; les teneurs en azote et en tomatine étaient toutes deux plus élevées dans les plantes contaminées par le virus. La survie a augmenté linéairement avec la teneur en azote, mais sans dépendre de la teneur en tomatine. L'influence positive pour L. decemlineata de la contamination par le virus peut être attribuée au moins en partie à la teneur en azote plus élevée. Nos résultats correspondent à l'hypothèse selon laquelle la consommation de plantes délaissées ou partiellement résistantes peut être augmentée par la contamination virale, et que cette contamination peut faciliter l'adaptation d'insectes phytophages sur des plantes marginalement consommables.
    Notes: Abstract Infection by tobacco mosaic virus improved the suitability of tomato, Lycopersicon esculentum Mill. for survival of Colorado potato beetle, Leptinotarsa decemlineata (Say), larvae. This improvement was due, at least in part, to the increase in total nitrogen content of virus-infected plants. The simultaneous increase in tomatine content had no discernable effect on L. decemlineata survival. Our results are consistent with the suggestions that virus infection may improve the suitability of partially resistant or non-preferred hosts, and that virus infection may facilitate the adaption of phytophagous insects to such ‘marginal’ host plant species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361306
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  • 5
    Electronic Resource
    Electronic Resource
    Response of winter wheat to N-fertiliser: Quantitative relations for components of growth (1987)
    Springer
    Nutrient cycling in agroecosystems 12 (1987), S. 119-137 
    Details
    ISSN: 1573-0867
    Keywords: fertiliser ; nitrogen ; regression ; response ; winter wheat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Measurements were made of yield of dry matter, plant-N content, and the distribution of mineral-N down the soil profile in 10 fertiliser-N experiments. In one of them detailed measurements were made throughout growth. Rate of N-uptake by the crop was unaffected by the amount of mineral-N in the upper 90 cm of soil when it was above about 30 kg N ha−1. The %N in plants that received ample N-fertiliser declined with increase in plant mass according to a previously derived equation. During senescence there was an apparent loss of N from the crop. N-nutrition in the different experiments had little effect on the partition of assimilate between grain and straw. At harvest grain and straw weights were well related by a linear model which had the same gradient but different intercepts for each experiment. Grain %N was about four times greater than straw %N. Regression analysis supported the view that high evaporative conditions or temperatures during the growing period induced earlier harvest dates, less grain relative to straw, and a higher %N in the plant when ample N-fertiliser was applied but not when N-fertiliser was withheld. Other analyses indicated that cereal roots were generally unable to extract mineral nitrogen from the soil when the concentration was less than about 0.18 kg N ha−1 cm−1, that at low levels of N-nutrition the recovery of available inorganic-N from soil by the grain and straw was about 80%, and that the average mineralisation rates from early spring to shortly after harvest date varied between 0.22 and 0.88 kg N ha−1 d−1 from site to site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01048913
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of once-monthly rifampicin and daily clofazimine on the pharmacokinetics of dapsone in leprosy patients in Nigeria (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 73-76 
    Details
    ISSN: 1432-1041
    Keywords: dapsone ; rifampicin ; clofazimine ; leprosy ; drug interaction ; multidrug therapy ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In leprosy patients in Nigeria the influence of daily clofazimine and of once-monthly rifampicin on the pharmacokinetics of dapsone has been investigated. Three days after rifampicin the elimination half-life of dapsone was reduced from 40.4 to 25.3 h (n=23). Correspondingly, the plasma dapsone 24 h after the last dose had fallen significantly from 2.63 to 2.02 mg/l. Clofazimine did not cause change in the pharmacokinetics of dapsone. It was concluded that, although rifamipicin had a considerable influence on the pharmacokinetics of dapsone, there is no reason to adjust the dose of dapsone during multidrug therapy of leprosy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01061421
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  • 7
    Electronic Resource
    Electronic Resource
    A possible drug interaction between rifampicin and enalapril (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 431-432 
    Details
    ISSN: 1432-1041
    Keywords: rifampicin ; enalapril ; hypertension ; drug interaction ; case report
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary When a 35-year-old man with essential hypertension was treated with antibiotics for brucellosis his blood pressure rose significantly. While all other treatment was kept constant rifampicin was discontinued. On rechallenge rifampicin did not alter serum concentrations of enalapril or the area under the curve (AUC) between 0 and 7 h, but it did reduce the AUC of the active metabolite enalaprilat by 31%. These observations suggest that there may be an interaction between rifampicin and enalapril, causing reduced hypotensive efficacy of enalapril. The mechanism of such an interaction merits further study, but it could be due to enhanced renal clearance of enalaprilat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561378
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  • 8
    Electronic Resource
    Electronic Resource
    Acute effects of amitriptyline on human performance and interactions with diazepam (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 585-592 
    Details
    ISSN: 1432-1041
    Keywords: amitriptyline ; diazepam ; pharmacodynamics ; body sway ; psychomotor performance ; drug interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects on psychomotor performance and attention of amitriptyline 75 mg administered without and with diazepam 10 mg have been investigated in 12 healthy subjects. The effects of the compounds were evaluated by objective tests (measurement of body sway, critical flicker fusion, visual reaction time, tachistoscopy, short term visual memory, tapping test, arithmetical calculation and Clement's code) and subjective measurements (visual analogue scales and side effects questionnaire). Measurements were taken before treatment and after 1, 3, 6, 8 and 24 h. Placebo did not affect either the objective or the subjective measurements. Diazepam caused a reduction in attention and performance after 1 h which had disappeared at 3 h. Amitriptyline caused a marked reduction in attention and performance, reaching a peak 3 hours after drug administration and persisting until 8 h. the deterioration in vigilance induced by amitriptyline was potentiated by concomitant diazepam.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637593
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  • 9
    Electronic Resource
    Electronic Resource
    Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 157-163 
    Details
    ISSN: 1432-1041
    Keywords: tolbutamide ; antipyrine ; selective inhibition ; metabolite formation ; pharmacokinetics ; drug interaction ; sulphaphenazole ; cimetidine ; primaquine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of sulphaphenazole, cimetidine and primaquine on the disposition of antipyrine and tolbutamide in healthy volunteers have been investigated. The model substrates were administered simultaneously in order more clearly to define any selective effects of the potential inhibitors. Sulphaphenazole produced a significant increase in the half-life of tolbutamide (7.10 to 21.50 h) and a correponding decrease in its clearance (0.260 to 0.084 ml·min−1·kg−1). Clearance to hydroxytolbutamide (OHTOL) and carboxytolbutamide (COOHTOL) was also significantly decreased. In contrast, sulphaphenazole had no effect on the disposition of antipyrine. Administration of cimetidine did not significantly alter the disposition of either model drug. However, a 1.6-times higher dose of cimetidine did increase the half lives both of tolbutamide and antipyrine (6.21 to 9.04 h and 14.2 to 19.2 h, respectively) and decrease their clearance (0.226 to 0.148 and 0.50 to 0.31 ml·min−1 kg−1, respectively). Clearance to OHTOL and hydroxymethylantipyrine (HMA) was reduced. A single dose of primaquine had no demonstrable effect on tolbutamide disposition whereas the half-life of antipyrine was increased (12.1 to 15.0 h) and its clearance decreased (0.63 to 0.38 ml·min−1·kg−1). The partial clearance to HMA, 4-hydroxyantipyrine (OHA) and norantipyrine (NORA) was also significantly reduced. The two main inferences are first, that tolbutamide and antipyrine are metabolished by different forms of cytochrome P-450, and second that a battery of model substrates is needed to investigate the inhibitory effects of a drug in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614553
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  • 10
    Electronic Resource
    Electronic Resource
    Femoxetine and cimetidine: Interaction in healthy volunteers (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 299-302 
    Details
    ISSN: 1432-1041
    Keywords: femoxetine ; cimetidine ; pharmacokinetics ; drug interaction ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The possibility of a pharmacokinetic interaction between femoxetine and cimetidine has been evaluated in 8 healthy volunteers. Two volunteers received single doses of femoxetine, and 6 were given multiple doses of femoxetine for 7 days with and without concurrent cimetidine. No influence of cimetidine was observed on the kinetics of single doses of femoxetine, but after multiple doses the plasma concentration of femoxetine was significantly increased. Similarly, the AUC at steady state tended to be increased, but not to a significant extent. Concurrent cimetidine did not cause a reduction in the AUC of the active desmethyl metabolite. It is recommended that femoxetine is given in reduced doses (e.g. 400 mg) when administered with cimetidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00981127
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