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  • galactokinase  (2)
  • Bio-electrical impedance  (1)
  • Cytochrome b5  (1)
  • Drosophila  (1)
  • Springer  (5)
  • American Geophysical Union (AGU)
  • American Meteorological Society
  • Blackwell Publishing Ltd
  • 2000-2004  (2)
  • 1990-1994  (3)
Collection
Keywords
Publisher
  • Springer  (5)
  • American Geophysical Union (AGU)
  • American Meteorological Society
  • Blackwell Publishing Ltd
Years
  • 2000-2004  (2)
  • 1990-1994  (3)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Analysis of a swallow homologue from Drosophila pseudoobscura (2000)
    Springer
    Development genes and evolution 210 (2000), S. 157-161 
    Details
    ISSN: 1432-041X
    Keywords: Key words Swallow ; bicoid ; Drosophila ; mRNA localization ; Oogenesis ; Embryogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  We analyzed a functional homologue of the swallow gene from Drosophila pseudoobscura. The swallow gene of D. melanogaster plays an essential role in localizing bicoid mRNA in oocytes, and swallow mutant embryos show anterior pattern defects that result from the lack of localization of the bicoid morphogen. The pseudoobscura homologue rescues the function of swallow mutants when introduced into the genome of D. melanogaster, and its expression is similar to that of the melanogaster gene. The predicted pseudoobscura and melanogaster proteins are 49% identical and 69% conserved. The coiled-coil domain previously identified in the melanogaster swallow protein is strongly conserved in the pseudoobscura homologue, but the weak similarity of the melanogaster swallow protein to the RNP class of RNA-binding proteins is not conserved in the pseudoobscura homologue. These and other observations suggest a structural role for swallow in localizing bicoid mRNA, perhaps as part of the egg cytoskeleton.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004270050023
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  • 2
    Electronic Resource
    Electronic Resource
    Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency (1991)
    Springer
    Biochemical genetics 29 (1991), S. 135-144 
    Details
    ISSN: 1573-4927
    Keywords: galactokinase ; thymidine kinase ; O6-methylguanine-DNA methyltransferase ; gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Expression of the enzymes galactokinase, thymidine kinase, and O6-methylguanine-DNA methyltransferase is occasionally coordinately regulated in human cell lines. We have measured the activities of these three enzymes in extracts of fibroblasts from individuals with hereditary galactokinase deficiency. These cells do not express measurable galactokinase activity. The levels of O6-methylguanine-DNA methyltransferase were in the normal range in cells from three galactokinase-deficient individuals. The activity of thymidine kinase in the affected cells was in the normal range for two of the three individuals. The reduced thymidine kinase activity in the third individual reflected the extremely poor growth of the cells in culture. Immortalization of one galactokinase-deficient cell line resulted in loss of O6-methylguanine-DNA methyltransferase activity, but the galactokinase and thymidine kinase levels remained unchanged. The data indicate that the loss of galactokinase activity in these individuals is the consequence of an alteration of gene expression which does not involve coordinate silencing with the thymidine kinase and methyltransferase loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554207
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  • 3
    Electronic Resource
    Electronic Resource
    Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency (1991)
    Springer
    Biochemical genetics 29 (1991), S. 135-144 
    Details
    ISSN: 1573-4927
    Keywords: galactokinase ; thymidine kinase ; O6-methylguanine-DNA methyltransferase ; gene regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Expression of the enzymes galactokinase, thymidine kinase, and O6-methylguanine-DNA methyltransferase is occasionally coordinately regulated in human cell lines. We have measured the activities of these three enzymes in extracts of fibroblasts from individuals with hereditary galactokinase deficiency. These cells do not express measurable galactokinase activity. The levels of O6-methylguanine-DNA methyltransferase were in the normal range in cells from three galactokinase-deficient individuals. The activity of thymidine kinase in the affected cells was in the normal range for two of the three individuals. The reduced thymidine kinase activity in the third individual reflected the extremely poor growth of the cells in culture. Immortalization of one galactokinase-deficient cell line resulted in loss of O6-methylguanine-DNA methyltransferase activity, but the galactokinase and thymidine kinase levels remained unchanged. The data indicate that the loss of galactokinase activity in these individuals is the consequence of an alteration of gene expression which does not involve coordinate silencing with the thymidine kinase and methyltransferase loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401808
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  • 4
    Electronic Resource
    Electronic Resource
    Stopped-flow fluorescence studies of the interaction of a mutant form of cytochrome b5 with lipid vesicles (1994)
    Springer
    Journal of fluorescence 4 (1994), S. 227-233 
    Details
    ISSN: 1573-4994
    Keywords: Cytochrome b5 ; site-directed mutagenesis ; kinetics ; fluorescence ; membrane-binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Cytochrome b5 binds spontaneously to lipid vescles and also self-associates in aqueous solution. Two mutant proteins have been generated, one has a self-association constant which is less than that of the native protein, while the other has a larger self-association constant. All three proteins have Trp in the membrane-binding domain but as aqueous solutions of these proteins contain differing amounts of monomeric protein, the kinetics of fluorescence enhancement, when the proteins are mixed with lipid vesicles, are complex. Similar complex kinetics are seen when the Trp are quenched by the addition of bromolipid vesicles. The mutant which has Trp 108 and 112 both replaced by Leu does not self-associate and shows monoexponential stopped-flow fluorescence kinetics. Identical rate constants are seen with this mutant for fluorescence enhancement by POPC and fluorescence quenching by three bromolipids with bromines at the 6,7-, 9,10-, and 11,12-positions of thesn-2 acyl chain. This rate constant is only 1% of the calculated collisional rate constant and it is suggested that the reduced rate is caused by a reduction in the number of productive collisions rather than by a slow rate of penetration of the membrane-binding domain into the bilayer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01878455
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  • 5
    Electronic Resource
    Electronic Resource
    Assessing the conditions forin vivo electrical virtual biopsies in Barrett's oesophagus (2000)
    Springer
    Medical & biological engineering & computing 38 (2000), S. 373-376 
    Details
    ISSN: 1741-0444
    Keywords: Virtual biopsies ; Barrett's oesophagus ; Bio-electrical impedance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract It has previously been shown that it is possible to differentiate between squamous and columnar epithelia in rat and resected human tissues using an impedance probe to makein vitro measurements. This probe can be passed down an endoscope allowing measurements to be made in patients. However, the probe emerges parallel to the oesophageal wall, with little room to manoeuvre. The conditions of control required to give reliable readings have been investigated. The importance of pressure applied and the angle of approach to the oesophagus was assessed. Pressures in the range 26.6 Pa to 46.3 kPa and angles in the range 15–90 degrees were considered. Inin vitro studies it was observed that it was possible to obtain consistent readings with pressures greater than 2.9 kPa and with angles greater than 15 degrees between the probe and the oesophagus. These conditions can be achievedin vivo, and readings obtained from twelve patients are shown (45 readings on normal squamous, 34 on Barrett's oesophagus and 22 on stomach). At low frequencies (9.6–153.2 kHz), a Mann-Whitney test shows a significant difference (p〈0.001) when comparing the means from squamous and columnar, and also when readings from Barrett's and normal gastric epithelia are compared (p〈0.001).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02345004
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