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  • 2000-2004  (5)
  • 1990-1994  (15)
  • 1980-1984  (15)
  • 1970-1974  (10)
  • 1
    Electronic Resource
    Electronic Resource
    Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones (1983)
    [s.l.] : Nature Publishing Group
    Nature 306 (1983), S. 791-792 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 The effect of infusion of monoclonal antibody against substance P into the ventral tegmental area (VTA) of the midbrain. Fig. 2 The effects of mild intermittent foot-shock and infusion of monoclonal antibody against substance P on 3,4-dihydroxyphenylacetic acid (DOPAC) levels in various ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/306791a0
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  • 2
    Electronic Resource
    Electronic Resource
    Inverse relationship between neurotensin receptors and neurotensin-like immunoreactivity in cat striatum (1984)
    [s.l.] : Nature Publishing Group
    Nature 307 (1984), S. 543-546 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Adult male cats received a lethal injection of pentobarbitone; their brains were removed and immersed in ice-cold saline for 10 min. Blocks containing the corpus striatum were frozen and sectioned in the transverse plane at 20 µ?? using a cryostat. Adjacent sections were incubated with either ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/307543a0
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  • 3
    Electronic Resource
    Electronic Resource
    Neurotensin in the rat anterior pituitary gland (1982)
    [s.l.] : Nature Publishing Group
    Nature 298 (1982), S. 163-165 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Pituitary samples were dissected and extracted as previously described10, and NTLI was measured with two radioim-munoassays using rabbit antisera directed against the amino-and carboxy-terminals of synthetic neurotensin10. The detection limit of each assay was 10 fmol per assay tube. NTLI was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/298163a0
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  • 4
    Electronic Resource
    Electronic Resource
    NEUROTENSIN: REGIONAL DISTRIBUTION, CHARACTERIZATION, AND INACTIVATION (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 400 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb31570.x
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  • 5
    Electronic Resource
    Electronic Resource
    NEUROTENSIN IN THE PITUITARY GLAND (1982)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 400 (1982), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1982.tb31597.x
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  • 6
    Electronic Resource
    Electronic Resource
    Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS (1984)
    [s.l.] : Nature Publishing Group
    Nature 309 (1984), S. 795-797 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The distribution of specific 3H-substance P-binding sites throughout the rat brain was initially determined. Adult male Sprague-Dawley rats were killed, their brains removed, frozen on dry-ice and 20-??? sections cut using a cryostat in either the horizontal or the coronal plane. They were apposed ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/309795a0
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  • 7
    Electronic Resource
    Electronic Resource
    Molecular neuropathology of Alzheimer's disease:In situ hybridization studies (1990)
    Springer
    Cellular and molecular neurobiology 10 (1990), S. 159-174 
    Details
    ISSN: 1573-6830
    Keywords: Alzheimer's disease ; senile plaques ; neurofibrillary tangles ; amyloid beta protein precursor ; microtubule-associated protein tau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Abundant senile plaques and neurofibrillary tangles in certain brain regions constitute the major neuropathological characteristics of Alzheimer's disease. Recent work has established that the amyloid beta protein, which is derived from a large precursor, constitutes the major constituent of plaque amyloid, whereas the microtubule-associated protein tau is a component of the paired helical filament, the major constituent of neurofibrillary tangles. 2. Multiple isoforms of amyloid beta protein precursor and tau protein are produced from a single gene through alternative RNA splicing. By Northern blotting amyloid beta protein precursor transcripts are found throughout central and peripheral tissues, whereas tau protein transcripts are only found in the nervous system. 3. In the central nervous system the cellular localization of amyloid beta protein precursor and tau protein transcripts is neuronal. The cells affected in Alzheimer's disease patients produce both types of transcripts; however, the various transcripts are also found in cells not affected in the course of the disease. At present, there exists no evidence to suggest that an overproduction of amyloid beta protein precursor or tau protein is the reason for plaque and tangle formation. The formation of the latter probably results from posttranslational events.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00733642
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  • 8
    Electronic Resource
    Electronic Resource
    Sources of error in chromatographic analysis. Effect of sampling parameters on the accuracy of numerical measurements (1973)
    Springer
    Chromatographia 6 (1973), S. 76-83 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary It is not possible in practice to carry out measurements in quantitative or qualitative analysis at a precision level better than 0.5% if conventional equipment such as recorders and electronic integrators are used to obtain the data. Only numerical techniques of on-line or off-line measurements associated with data handling by computer can be used. From their very nature numerical techniques are discontinuous and the number of experimental points is limited. According to information theory this discontinuous character does not imply a loss of accuracy provided that some simple relationship derived from the theory of sampled systems is fulfilled. These conditions deal with the choice of the sampling frequency, the frequency band-width of the amplifier and measurement system, and the upper limit of the signal frequency. We have made a theoretical and an experimental study of these phenomena and the results allow us to derive some simple rules which make the choice of parameters of the system of data acquisition easy. We have also determined the main sources of error in data acquisition systems and calculated their contribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02270542
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  • 9
    Electronic Resource
    Electronic Resource
    Etude des sources d'erreurs en chromatogrpahie en phase gazeuse. V. Simulation d'un processus d'acquisition et de calcul (1973)
    Springer
    Chromatographia 6 (1973), S. 116-128 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Résumé Une simulation sur un ordinateur du processus de mesure digitale d'un signal chromatographique permet de calculer rapidement les erreurs commises sur les diffèrents moments du pic, du simple fait de la digitalisation de ce signal. On étudie l'influence de la largeur de la fenêtre d'intégration. de la fréquence des mesures et de leur décalage par rapport au signal sur l'erreur commise et l'on montre comment plus un pic est dissymétrique plus les mesures doivent être faites dans une large fenêtre et avec une densité élevée pour que la justesse avec lacquelle sont calculés les différents moments atteigne une valeur donnée. Lorsque l'ordre du moment s'élève, la densité des mesures nécessaire pour atteindre une justesse donnée diminue, mais la largeur de la fenêtre d'intégration augmente sensiblement. Ces résultats permettent de définir facilement les conditions d'acquisition d'un signal chromatographique en fonction de l'applciation projetée.
    Notes: Summary Using a computer simulation of the chromatographic signal acquisition process, errors made in the calculation of the various moments are determined. The effects of the width of the time window used for the integration, of the density of data points and of the shift between the peak maximu mand the nearest data point on the these errors are studied. The more unsymmetrical a peak, the larger the time window and the higher the density of data which are necessary to reach a given level of accuracy. The density of data points decreases while the width of the time window increase with increasing moment order. These results allow the ready determination of the optimum values of the parameters of the data acquisition system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02312111
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  • 10
    Electronic Resource
    Electronic Resource
    Application of an inexpensive, general-purpose microcomputer in analytical chemistry (1974)
    Springer
    Chromatographia 7 (1974), S. 539-546 
    Details
    ISSN: 1612-1112
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Minicomputers are often underemployed and could be replaced by less powerful systems. The need for a product with characteristics intermediate between the minicomputer and hardwired systems resulted recently in the commercialization of inexpensive microprocessor units. A general purpose microcomputer has been designed around such a microprocessor unit, and the capabilities and limitations of this new device, when used to solve problems encountered in an analytical laboratory, are reported. Examples include: (1) on-line filtering of an analog signal at the output of a liquid chromatograph, (2) use as a buffer memory to rapidly store data from a GC/MS and then output it slowly on an inexpensive recorder, and (3) the analysis of noise from a new liquid chromatography detector using a conventional recorder as a storage oscilloscope. Applications for these inexpensive units are limitless, and we foresee their use in almost every field of instrumentation in future years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02268338
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