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  • Cell Press  (8)
  • Wiley-Blackwell  (8)
  • EDP Sciences  (6)
  • National Academy of Sciences  (5)
  • Blackwell Publishing Ltd
  • 2000-2004  (10)
  • 1995-1999  (19)
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  • 1
    Electronic Resource
    Electronic Resource
    M protein of a Streptococcus dysgalactiae human wound isolate shows multiple binding to different plasma proteins and shares epitopes with keratin and human cartilage (1999)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 26 (1999), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Besides group A (GAS), Lancefield group C β-haemolytic streptococci (GCS) have been implicated as a causative agent in outbreaks of purulent pharyngitis. In this study we have investigated a class CI M protein of a Streptococcus dysgalactiae human wound isolate designated MC. MC shares similar properties with M proteins of GAS. It contributes to the virulence of the investigated GCS strain as revealed by in vivo phagocytosis in chicken embryos. Further, MC showed multiple binding to the human plasma proteins fibrinogen, albumin, plasminogen, IgA and all subclasses of IgG. Until now, an M protein, especially from a group C strain, with such a multiple binding behaviour has not been described. Immunoblot experiments with 150 patient sera, having a rheumatoid factor titre 〉1:256, revealed that 26% of these sera showed serological cross-reactivity between a 68-kDa cartilage protein and the N-terminal part of MC. Only 8% of the sera of healthy patients showed this property. In additional, MC also cross-reacted with antibodies recognising epidermal keratins. The cross-reacting 68-kDa protein from cartilage was different from human serum albumin, but was recognised with anti-vimentin immune serum. The MC was cloned and the gene sequenced. By using PCR, recombinant gene fragments encoding characteristic peptide fragments of MC were expressed in Escherichia coli. The peptides were used to map the binding sites for plasma proteins and to locate the cross-reacting epitopes on the MC molecule. In consequence, sequence alignments revealed that MC shared homologous regions with vimentin and different keratins. Our data, obtained with MC, suggest that not only infections with GAS but also infections with GCS and possibly GGS (the latter species can also produce class CI M-like proteins) may be responsible for the formation of streptococcal-associated sequel diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1999.tb01368.x
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  • 2
    Electronic Resource
    Electronic Resource
    Chlorobenzene biodegradation under consecutive aerobic–anaerobic conditions (2004)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology ecology 49 (2004), S. 0 
    Details
    ISSN: 1574-6941
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The biodegradation of monochlorobenzene, the main contaminant in a quaternary aquifer at Bitterfeld, Central Germany, was studied in microcosm experiments employing either original groundwater or defined mineral media together with the indigenous microbial community from the polluted site. The impact of consecutive aerobic–anaerobic–aerobic incubations on monochlorobenzene biodegradation, microbial diversity, and pH development was examined. The related changes in microbial community composition were analyzed by 16S rRNA gene-based single-strand conformation polymorphism (SSCP) fingerprints and sequencing of dominant bands and by quantitative analysis of bacterial respiratory chain quinones as biomarkers. Under aerobic conditions, the indigenous microbial community of the groundwater degraded monochlorobenzene mainly via the modified ortho-pathway. Respiratory chain quinones and SSCP analysis suggested dominance of the genera Acidovorax and Pseudomonas. A shift to anoxic conditions resulted in monochlorobenzene biotransformation but no dechlorination. The ability to degrade monochlorobenzene aerobically remained preserved throughout a fortnightly anoxic period at sufficiently high buffer capacity. Acidification, caused by monochlorobenzene biodegradation, was alkalinity-controlled. At low initial alkalinity a substantial decrease in pH, monochlorobenzene degradation, and total counts of live cells, accompanied by a change of the microbial community composition, was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsec.2003.08.014
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  • 3
    Electronic Resource
    Electronic Resource
    C-Disaccharides of Ketoses (1996)
    Weinheim : Wiley-Blackwell
    Chemistry - A European Journal 2 (1996), S. 502-510 
    Details
    ISSN: 0947-6539
    Keywords: alkynes ; C-glycosides ; cobalt complexes ; cyclizations ; enzyme inhibitors ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Reaction of gluconolactone 2 with allylmagnesium bromide at low temperatures afforded ketopyranose 3, which could easily be converted into open-chain ketoses (R)-6 and (S)-6. Their reaction with lithioacetylide 9 afforded propargylic alcohol derivatives (R)-10 and (S)-10, which could not be cyclized directly to the desired C-ketosides. They were converted by standard procedures into (R)-14 and (S)-14 and then into dicobalthexacarbonyl complexes (R)-16 and (S)-16. A facile acid-catalyzed ring closure gave the desired C-ketosides (R)-18 α/β and (S)-18α/β, respectively, in different ratios. In order to demonstrate that removal of the protective groups and hydrogenation of the CC triple bond proceed smoothly, (R)-18 α was transformed into the deprotected target molecule (R)-1 α. For the assignment of the new chiral centers at C-2/2′ and at C-8, (S)-18α was transformed into azido derivative (S)-22α, which underwent intramolecular cycloaddition to afford the spiro derivative (S)-25α. Because of the conformational constraints in this molecule, unequivocal configurational assignment was possible with the help of NMR data.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chem.19960020508
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  • 4
    Electronic Resource
    Electronic Resource
    Polyol Peptidomimetics (2000)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 2000 (2000), S. 1113-1120 
    Details
    ISSN: 1434-193X
    Keywords: Peptidomimetics ; Reverse turn mimetics ; Glycomimetics ; Heterocycles ; Lactams ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: -D-Glucurono-3,6-lactone and L-cysteine combine in a highly stereoselective manner to give the 7,5-bicyclic thiazolidinlactam 2. The α-hydroxy group of the D-glucurono-3,6-lactone was exchanged for an amino function (to give 13) and, after condensation with L-cysteine methyl ester, the polyol dipeptide 7 was obtained. Peptide couplings proceed without the need to protect the three secondary hydroxy groups of the seven-membered ring. The amino group of 7 was deprotected and selectively elongated to the pseudo-tripeptide 16. The depsipeptide 17 was obtained by condensation of Boc-Ala-OH with the polyol 2. Elongation at the carboxy terminus yielded 19 and 20. The bicyclic scaffold populates a well-defined solution conformation; the hydroxy groups mimic the side chains of hydrophilic amino acids and can be further functionalized.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Diastereoselective Substitution of PR3 for CO in Carbene(dicarbonyl)cyclopentadienyl Complexes of Manganese - Synthesis of (SMn)- and (RMn)-[Cp(CO)(PR3)Mn=C(OR*)R′] Complexes (1998)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 1998 (1998), S. 339-347 
    Details
    ISSN: 1434-1948
    Keywords: Carbene complexes ; Carbyne complexes ; Asymmetric synthesis ; Carbohydrates ; Chiral auxiliaries ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chiral carbene complexes [Cp(CO)2Mn=C(OR*)Ph] (4a-e) were prepared by reaction of [Cp(CO)2Mn=C(OAc)Ph] (2) with HOR* [HOR* = 1,2:3,4-di-O-isopropylidene-D-galactopyranose (3a), 2,3,4,6-tetra-O-acetyl-D-galactopyranose (3b), 2,3,4,6-tetra-O-acetyl-D-glucopyranose (3c), (S)- (3d) and (R)-1,2-O-isopropylideneglycerol (3e)]. The replacement of a CO ligand with PTol3 in 4a-e proceeded diastereoselectively to give [Cp(CO)(PTol3)Mn=C(OR*)Ph] (5a-e). The diastereoselectivity increased in the order a, b, c, d: de = 8% (5a), 33% (5b), 70% (5c), 〉 96% (5d). For (R)-5d the isomer with the (S) configuration at manganese (SMn) was formed predominantly. For (S)-5d, only (RMn,S)-5d was detected (de 〉 96%). Photolysis of (R)-4d in the presence of phosphites or phosphanes afforded (SMn)-[Cp(CO)(PR3)Mn=C(OR*)Ph] [PR3 = P(OPh)3 (8), P(OMe)3 (9), P(OMe)2Ph (10), P(OMe)Ph2 (11), PPh3 (12), P(C6H4Cl-p)3 (13)] with a de 〉 96%. Photolysis of (S)-4d in the presence of P(OMe)3 gave (RMn,S)-9. Complex (R)-14 [related to (R)-4d] was obtained from [Cp(CO)2Mn=C(OAc)Tol-p] and 3d. Replacement of CO by PR3 in (R)-14 gave (SMn,R)-[Cp(CO)(PR3)Mn=C(OR*)Tol-p] [R = Tol-p (15), OMe (16), C6H4Cl-p (17)] with a de 〉 96%. In solution, the PTol3-substituted complex 5d is configurationally stable whereas the P(OMe)3 complex 9 epimerizes slowly at room temperature in CH2Cl2, Et2O, and THF within about one week.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Enzymes in polymer chemistry, 8Part 7: cf. ref.19. Chemoenzymatic synthesis of polymerizable 11-methacryloyl-aminoundecanoic ester of 1- and 3-O-methyl-α-D-glucose in 6-O-position (1995)
    Weinheim : Wiley-Blackwell
    Macromolecular Rapid Communications 16 (1995), S. 337-341 
    Details
    ISSN: 1022-1336
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The paper describes the regioselective esterification of a glucopyranoside and glucose derivative with 11-methacryloylaminoundecanoic acid in the presence of a lipase from Candida antarctica. The obtained modified sugar derivatives 6-O-(11-methacryloylaminoundecanoyl)-1-O-methyl-α-D-glucopyranoside (3 a) and 6-O-(11-methacryloylaminoundecanoyl)-3-O-methyl-α-D-glucopyranose (3 b) were polymerized radically with AIBN as initiator.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/marc.1995.030160417
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  • 7
    Electronic Resource
    Electronic Resource
    Structural motifs of the dimeric lewis glycolipids as determined by NMR spectroscopy and molecular dynamics simulations (1996)
    Weinheim : Wiley-Blackwell
    Chemistry - A European Journal 2 (1996), S. 981-988 
    Details
    ISSN: 0947-6539
    Keywords: computer simulations ; conformations ; Lewis glycolipids ; molecular dynamics ; thioglycosides ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Several monomeric and dimeric Lewis glycolipids have been investigated by NMR spectroscopy, and structural aspects were modelled by computer. From the pseudo-C2-symmetric tetrasaccharide unit that forms the recognition domain of the Lewis Y and Lewis b antigens, a totally C2-symmetric tetrasaccharide was designed that contains the structural element common to all Lewis antigens. Finally, a model for the presentation of dimeric Lewis antigens at membrane surfaces was derived. The overall shapes of the dimeric Lewis oligosaccharides are defined by the connectivity of the sugar residues within rigid tri- and tetrasaccharide building blocks.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chem.1460020811
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  • 8
    Electronic Resource
    Electronic Resource
    Nickelreiche Ni/Al2O3-Katalysatoren stark variierter Makroporosität (1995)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 67 (1995), S. 1330-1332 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330671014
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  • 9
    Electronic Resource
    Electronic Resource
    Das makrolidische Glycolipid Calonyctin A, ein Pflanzenwachstumsregulator - Synthese, Konfigurationszuordnung und Konformationsanalyse in micellarer LösungDiese Arbeit wurde von der Deutschen Forschungsgemeinschaft und vom Fonds der Chemischen Industrie unterstützt. (1995)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 107 (1995), S. 2730-2734 
    Details
    ISSN: 0044-8249
    Keywords: Calonyctin A ; Glycolipide ; Glycosidsynthesen ; Makrolide ; Moleküldynamiksimulation ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19951072220
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  • 10
    Electronic Resource
    Electronic Resource
    The Macrolidic Glycolipid Calonyctin A, a Plant Growth Regulator: Synthesis, Structural Assignment, and Conformational Analysis in Micellar SolutionThis work was supported by the Deutsche Forschungsgemeinschaft and the Fonds der Chemischen Industrie. (1995)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 34 (1995), S. 2520-2524 
    Details
    ISSN: 0570-0833
    Keywords: calonyctin A ; glycolipids ; glycoside syntheses ; macrolides ; molecular dynamics simulation ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.199525201
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