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  • 2000-2004  (61)
  • 1995-1999  (59)
  • 1955-1959  (10)
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  • 1
    Electronic Resource
    Electronic Resource
    Radioassay of Aqueous Samples (1959)
    s.l. : American Chemical Society
    Analytical chemistry 31 (1959), S. 1746-1746 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60154a012
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  • 2
    Electronic Resource
    Electronic Resource
    YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositoI 3-kinase pathway (2002)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 45 (2002), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Phosphatidylinositol 3-kinase (PI 3-kinase) and its target protein kinase B (Akt) are involved in various processes including internalization, chemotaxis and proliferation. We analysed the activation of Akt in J774 macrophages infected with virulent (pYV+) or avirulent (pYV−) Yersinia enterocolitica. During the early stage of infection with pYV+ and pYV− bacteria, Akt and its targets, glycogen synthase kinase 3 (GSK-3) and forkhead transcription factor (FKHRL1), became phosphorylated. This phosphorylation induction was inhibited by wortmannin and thus dependent on PI 3-kinase. When infection was carried out with pYV+ bacteria but not with pYV− bacteria, Akt and its targets became dephosphorylated at later time points. Using single knock-out mutants in bacterial effector genes, we have determined that the tyrosine phosphatase YopH was responsible for the inactivation of the PI 3-kinase cascade. In macrophages, this inactivation correlated with the downregulation of mRNA coding for monocyte chemoattractant protein 1 (MCP-1), suggesting that YopH inhibits recruitment of macrophages to lymph nodes. We also analysed the effects of Y. enterocolitica infection on the proliferation of T lymphocytes. Consistent with the observation that YopH inactivated the Akt pathway, YopH inhibited PI 3-kinase-dependent secretion of interleukin 2 and proliferation. These data reveal a new effect of YopH in Yersinia pathogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2002.03053.x
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  • 3
    Electronic Resource
    Electronic Resource
    The provision of education and training for health care professionals through the medium of the Internet (2002)
    Bradford : Emerald
    Campus-wide information systems 19 (2002), S. 135-144 
    Details
    ISSN: 1065-0741
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Computer Science
    Notes: Describes a new and experimental initiative to provide Internet-based courses to student and professional occupational therapists in four centres in the UK, Belgium, The Netherlands and Sweden. The basis of this collaborative Occupational Therapy Internet School (OTIS) is the concept of the "Virtual College". The aim is to support and facilitate the whole range of educational activities within a remote electronic environment. A major feature of the course organisation is the adoption of a problem-based approach in which students will collaborate internationally to propose effective intervention in given case study scenarios. Outlines the rationale for OTIS, the content and structure of the courseware, the technical specification of the system and evaluation criteria. In addition to the more conventional Web-based learning facilities generally offered, a number of agent-based approaches are being adopted to assist in the management of the course by ensuring the proper delivery of course materials and to assist the functioning of project groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/10650740210438829
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  • 4
    Electronic Resource
    Electronic Resource
    Transparent Alumina: A Light-Scattering Model (2003)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 86 (2003), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A model based on Rayleigh–Gans–Debye light-scattering theory has been developed to describe the light transmission properties of fine-grained, fully dense, polycrystalline ceramics consisting of birefringent crystals. This model extends light transmission models based on geometrical optics, which are valid only for coarse-grained microstructures, to smaller crystal sizes. We verify our model by measuring the light transmission properties of fully dense (〉99.99%), polycrystalline α-Al2O3 (PCA) with mean crystal sizes ranging from 60 to 0.3 μm. The remarkable transparency exhibited by PCA samples with small crystal sizes (〈2 μm) is well explained by this model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.2003.tb03325.x
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  • 5
    Electronic Resource
    Electronic Resource
    Transparent Sintered Corundum with High Hardness and Strength (2003)
    Westerville, Ohio : American Ceramics Society
    Journal of the American Ceramic Society 86 (2003), S. 0 
    Details
    ISSN: 1551-2916
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Commercial corundum powder and a liquid-shaping approach are used for manufacturing complex hollow components and large flat windows of sintered and hot isostatically pressed Al2O3 ceramics having grain sizes of 0.4–0.6 μm at relative densities of 〉99.9%. High macrohardness (HV10 = 20–21 GPa) and four-point bending strength (600–700 MPa; 750–900 MPa in three-point bending) are associated with a real in-line transmission of 55%–65% through polished plates. The submicrometer microstructure and the optical properties can be retained for use at 〉1100°C using dopants that shift the sintering temperature to high values without additional grain growth.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1151-2916.2003.tb03270.x
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  • 6
    Electronic Resource
    Electronic Resource
    The powerful triangle of marketing data, managerial judgment, and marketing management support systems (2001)
    Bradford : Emerald
    European journal of marketing 35 (2001), S. 796-816 
    Details
    ISSN: 0309-0566
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Conceptualizes the impact of information technology on marketing decision making. Argues that developments in information technology affect the performance of marketing decision-makers through different routes. Advances in information technology enhance the possibilities of collecting data and of generating information for supporting marketing decision making. Potentially, this will have a positive impact on decision-making performance. Managerial expertise will favor the transformation of data into market insights. However, as the cognitive capabilities of marketing managers are limited, increasing amounts of data may also increase the complexity of the decision-making context. In turn, increased complexity enhances the probability of biased decision processes, thereby negatively affecting decision-making performance. Marketing management support systems, also being the result of advances in information technology, are tools that can help marketers to benefit from the data explosion. The analysis leads to the expectation that the combination of marketing data, managerial judgment, and marketing management support systems will be a powerful factor for improving marketing management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/EUM0000000005726
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  • 7
    Electronic Resource
    Electronic Resource
    Potential role of CCR5 polymorphism in the development of AIDS dementia complex (1999)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 26 (1999), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The chemokine receptor CCR5 and to a lesser extent CCR2b and CCR3 have been shown to serve as coreceptors for HIV-1 entry into macrophages. Individuals that are homozygous for a defective CCR5 allele (ΔCCR5) are highly, but not fully, resistant to infection with HIV-1. Here, we want to emphasize the importance of ΔCCR5 in in vitro as well as in vivo studies. We provide data that suggest that CCR5 polymorphism may affect the onset of AIDS dementia complex in vivo and data that show that HIV-1 replication is influenced by the ΔCCR5 allele in vitro. Knowing the CCR5 genotype of an individual will help to better interpret research results and may even provide new information about mechanisms of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.1999.tb01395.x
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  • 8
    Electronic Resource
    Electronic Resource
    Recognition by human Vγ9/Vδ2 T cells of melanoma cells upon fusion with Daudi cells (1996)
    Springer
    Immunogenetics 45 (1996), S. 27-34 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Daudi Burkitt’s lymphoma cells, unlike other tumor cell lines, stimulate human T cells coexpressing the variable (V) region genes TCRG-V9 and V TCRD-V2 to proliferate and secrete lymphokines. Hybrids, derived by the fusion of Daudi cells with the human melanoma cell line MZ2-MEL 2.2, retain the morphology of melanoma cells. Unlike the parental melanoma cell line, these Daudi × MZ2-MEL 2.2 hybrids stimulate secretion of tumor necrosis factor (TNF) and granulocyte/macrophage colony stimulating factor (GM-CSF) by CD4-positive Vγ9/Vδ2 T-cell clones. Whereas the stimulator phenotype of Daudi cells behaves as a dominant trait in Daudi × melanoma hybrids, the expression of B-cell differentiation markers is suppressed. Thus, the γ/δ T-cell ligand expressed by Daudi cells behaves as a dominant tumor antigen in Daudi × melanoma hybrids and is unrelated to the differentiated B-cell phenotype. Dominant expression of the Daudi ligand for human Vγ9/Vδ2 T cells in these hybrids may provide a basis for defining the stimulatory principle at the molecular level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050163
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  • 9
    Electronic Resource
    Electronic Resource
    A peptide encoded by the human MAGE3 gene and presented by HLA-1344 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3 (1996)
    Springer
    Immunogenetics 43 (1996), S. 377-383 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The humanMAGE3 gene is expressed in a significant proportion of tumors of various histological types, but is silent in normal adult tissues other than testis and placenta. Antigens encoded byMAGE3 may therefore be useful targets for specific antitumor immunization. Two antigenic peptides encoded by theMAGE3 gene have been reported previously. One is presented to cytolytic T lymphocytes (CTL) by HLA-A1, the other by HLA-A2 molecules. Here we show that MAGE3 also codes for a peptide that is presented to CTL by HLA-1344.MAGE3 peptides containing the HLA-1344 peptide binding motif were synthesized. Peptide MEVDPIGHLY, which showed the strongest binding to HLA-1344, was used to stimulate blood T lymphocytes from normal HLA-1344 donors. CTL clones were obtained that recognized not only HLA-B44 cells sensitized with the peptide, but also HLA-B44 tumor cell lines expressingMAGE3. The proportion of metastatic melanomas expressing theMAGE3/HLA-1344 antigen should amount to approximately 17% in the Caucasian population, since 24% of individuals carry theHLA-B44 allele and 76% of these tumors express MAGE3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02199806
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  • 10
    Electronic Resource
    Electronic Resource
    The localization of histone H3.3 in germ line chromatin of Drosophila males as established with a histone H3.3-specific antiserum (1997)
    Springer
    Chromosoma 106 (1997), S. 335-347 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. A rabbit antiserum, specific for the histone H3.3 replacement variant, was raised with the aid of a histone H3.3-specific peptide. Immuno blot experiments demonstrated the specificity of this polyclonal antiserum. In addition, we showed on immuno blots that two monoclonal antibodies isolated from mice with systemic lupus erythematosus (SLE) display strong reactivity with the H3.3 histone, but not with its replication-dependent counterparts. Our observations indicate that histone H3.3 might play a role as autoantigen in SLE. We used the histone H3.3-specific antiserum to characterize the germ line chromatin in cytological preparations of Drosophila testes, because our previous studies had shown that a histone H3.3-encoding gene is strongly expressed in the germ line of Drosophila males. The antiserum reacted with some of the lampbrush loops in spermatocytes and with chromatin of the postmeiotic germ cells of males. Our data indicate that histone H3.3 is not evenly distributed throughout the chromatin of germ cells, but is concentrated in distinct regions. Histone H3.3 disappears from the spermatid nuclei, along with the other core histones, during the late stages of spermatogenesis. In Drosophila polytene chromosomes, however, a rather uniform distribution of the histone H3.3 was observed. The possible role of histone H3.3 is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004120050255
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