Publication Date:
2005-09-24
Description:
Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of mouse enamel knots. Furthermore, we show that ectodin-deficient mice have enlarged enamel knots, highly altered cusp patterns, and extra teeth. Unlike in normal teeth, excess BMP accelerates patterning in ectodin-deficient teeth. We propose that ectodin is critical for robust spatial delineation of enamel knots and cusps.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kassai, Yoshiaki -- Munne, Pauliina -- Hotta, Yuhei -- Penttila, Enni -- Kavanagh, Kathryn -- Ohbayashi, Norihiko -- Takada, Shinji -- Thesleff, Irma -- Jernvall, Jukka -- Itoh, Nobuyuki -- New York, N.Y. -- Science. 2005 Sep 23;309(5743):2067-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16179481" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Body Patterning
;
Bone Morphogenetic Protein 4
;
Bone Morphogenetic
;
Proteins/biosynthesis/genetics/metabolism/pharmacology/*physiology
;
Cell Cycle Proteins/biosynthesis/genetics/physiology
;
Chimera
;
Cyclin-Dependent Kinase Inhibitor p21
;
Dental Enamel/embryology
;
Gene Expression Regulation, Developmental
;
Hedgehog Proteins
;
Heterozygote
;
Mice
;
Mice, Inbred C57BL
;
Microscopy, Confocal
;
Molar/embryology/metabolism
;
Mutation
;
*Odontogenesis
;
Organ Culture Techniques
;
Tooth Crown/*embryology
;
Trans-Activators/biosynthesis/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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