Publication Date:
2007-12-15
Description:
Kelly et al. (Brevia, 20 July 2007, p. 337) questioned xenotransplant experiments supporting the cancer stem cell (CSC) hypothesis because they found a high frequency of leukemia-initiating cells (L-IC) in some transgenic mouse models. However, the CSC hypothesis depends on prospective purification of cells with tumor-initiating capacity, irrespective of frequency. Moreover, we found similar L-IC frequencies in genetically comparable leukemias using syngeneic or xenogeneic models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, James A -- Barabe, Frederic -- Poeppl, Armando G -- Wang, Jean C Y -- Dick, John E -- New York, N.Y. -- Science. 2007 Dec 14;318(5857):1722; author reply 1722.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell and Molecular Biology, University Health Network, Toronto, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18079385" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bone Marrow Cells/pathology
;
Bone Marrow Transplantation
;
Cell Separation
;
Disease Models, Animal
;
Humans
;
Leukemia/*pathology/physiopathology
;
Leukemia, Myeloid, Acute/pathology/physiopathology
;
Mice
;
Mice, Transgenic
;
Neoplasm Transplantation
;
Neoplastic Stem Cells/pathology/*physiology
;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology/physiopathology
;
Transplantation, Heterologous
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
