Publication Date:
2006-03-25
Description:
Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in Drosophila. Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1509097/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1509097/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Xiao-Hong -- Aliyari, Roghiyh -- Li, Wan-Xiang -- Li, Hong-Wei -- Kim, Kevin -- Carthew, Richard -- Atkinson, Peter -- Ding, Shou-Wei -- AI052447/AI/NIAID NIH HHS/ -- R01 AI052447/AI/NIAID NIH HHS/ -- R01 GM068743/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Apr 21;312(5772):452-4. Epub 2006 Mar 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Graduate Program for Microbiology, University of California, Riverside, CA 92521, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16556799" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Argonaute Proteins
;
Cell Line
;
Drosophila Proteins/genetics/metabolism/physiology
;
Drosophila melanogaster/embryology/genetics/*immunology/*virology
;
Embryo, Nonmammalian/immunology/virology
;
Escherichia coli/physiology
;
*Immunity, Innate
;
Insect Viruses/genetics/*physiology
;
Micrococcus luteus/physiology
;
Mutation
;
Nodaviridae/*physiology
;
RNA Helicases/genetics/metabolism
;
*RNA Interference
;
RNA Viruses/genetics/physiology
;
RNA, Double-Stranded/metabolism
;
RNA, Small Interfering/metabolism
;
RNA, Viral/genetics/metabolism
;
RNA-Binding Proteins/genetics/physiology
;
RNA-Induced Silencing Complex/genetics/physiology
;
Ribonuclease III
;
Signal Transduction
;
Toll-Like Receptors/physiology
;
Transfection
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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