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  • 1
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    Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-04-12
    Description: The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of pathogenic dust is recognized and how chronic inflammatory diseases are triggered are poorly understood. Here, we show that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1beta secretion. Inflammasome activation is triggered by reactive oxygen species, which are generated by a NADPH oxidase upon particle phagocytosis. (NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate.) In a model of asbestos inhalation, Nalp3-/- mice showed diminished recruitment of inflammatory cells to the lungs, paralleled by lower cytokine production. Our findings implicate the Nalp3 inflammasome in particulate matter-related pulmonary diseases and support its role as a major proinflammatory "danger" receptor.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396588/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2396588/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dostert, Catherine -- Petrilli, Virginie -- Van Bruggen, Robin -- Steele, Chad -- Mossman, Brooke T -- Tschopp, Jurg -- P01 CA114047/CA/NCI NIH HHS/ -- P01 CA114047-01A10002/CA/NCI NIH HHS/ -- P01HL67004/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2008 May 2;320(5876):674-7. doi: 10.1126/science.1156995. Epub 2008 Apr 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18403674" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Asbestos/*immunology ; Carrier Proteins/*physiology ; Humans ; Immunity ; Inflammation/*immunology ; Inflammation Mediators/*physiology ; Interleukin-1beta/secretion ; Macrophages/immunology/secretion ; Mice ; Silicon Dioxide/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Gulella johannae spec. nov. (Gastropoda, Pulmonata, Streptaxidae), a new land snail from the Drakensberg range in Limpopo Province, South Africa, with notes on G. johannesburgensis (M. & P.) (2006)
    In:  Zoologische Mededelingen (0024-0672) vol.80 (2006) nr.1 p.63
    Details
    Publication Date: 2010-12-12
    Description: Gulella (s.l.) johannae n. sp. is described from a few forest localities in the Tzaneen District, Limpopo Province, South Africa. It is characterized by a cylindrical, costulate shell with an almost entire peristome and a four-fold apertural dentition consisting of a prominent angular lamella (delimiting an only here discontinuous peristome), a mid-labral denticle, a left basal denticle, and a mid-columellar process. The shell is somewhat similar to that of G. johannesburgensis, but is consistently larger and more slender and has more whorls, while at the same time the apertural dentition is better developed; the almost uninterrupted peristome also appears to be a signifi cant character. This new taxon most likely is a restrictedrange endemic on the eastern flanks of the northern Drakensberg escarpment. Numerical data of a lot of material identified and mostly also published as G. johannesburgensis show that probably not all specimens belong to this taxon so that more than one species may be involved here.
    Keywords: Mollusca ; Gastropoda ; Pulmonata ; Streptaxidae ; Gulella, Gulella johannesburgensis ; taxonomy ; Drakensberg range ; South Africa ; 42.73
    Repository Name: National Museum of Natural History, Netherlands
    Type: Article / Letter to the editor
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  • 3
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    Studies on the Streptaxidae (Mollusca: Gastropoda Pulmonata) of Mala\xc5\xb5i 10. Description of Gulella systemanaturae, a new species from Dedza Mountain (2008)
    In:  Zoologische Mededelingen vol. 82 no. 2, pp. 9-14
    Details
    Publication Date: 2024-01-12
    Description: Gulella systemanaturae spec. nov. is described from Dedza Mt. in South-Central Mala\xc5\xb5i. The mediumsized shell is characterized by little prominent costulation and a four-fold apertural dentition consisting of angular lamella, labral process, and outer and inner columellar processes. The labrum is sharply angulate at its point of attachment to the body whorl near the angular lamella.
    Keywords: Gastropoda ; Pulmonata ; Streptaxidae ; Gulella ; taxonomy ; Mala\xc5\xb5i
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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  • 4
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    Studies on the Streptaxidae (Mollusca: Gastropoda Pulmonata) of Malawi9. Description of Gulella streptostelopsis, a new Streptostele-like species of Gulella. (2007)
    In:  Zoologische Mededelingen vol. 81, pp. 1-9
    Details
    Publication Date: 2024-04-16
    Description: Gulella streptostelopsis spec. nov. is described from a series of localities of mainly between 1000 and 1500 m a.s.l. in Malawi south of about 11°S. The minute, almost smooth, shell (length 2.0-2.4 mm) resembles that of the genus Streptostele (hence the name), but is characterized by three-fold apertural dentition and just under six whorls. This taxon may represent a new genus; pending studies on the anatomy no new generic name is proposed.
    Keywords: Gastropoda ; Pulmonata ; Streptaxidae ; Gulella ; Streptostele ; taxonomy ; Malawi ; East Africa
    Repository Name: National Museum of Natural History, Netherlands
    Type: info:eu-repo/semantics/article
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