Publication Date:
2007-06-16
Description:
The cytokine transforming growth factor-beta (TGF-beta) converts naive T cells into regulatory T (Treg) cells that prevent autoimmunity. However, in the presence of interleukin-6 (IL-6), TGF-beta has also been found to promote the differentiation of naive T lymphocytes into proinflammatory IL-17 cytokine-producing T helper 17 (T(H)17) cells, which promote autoimmunity and inflammation. This raises the question of how TGF-beta can generate such distinct outcomes. We identified the vitamin A metabolite retinoic acid as a key regulator of TGF-beta-dependent immune responses, capable of inhibiting the IL-6-driven induction of proinflammatory T(H)17 cells and promoting anti-inflammatory Treg cell differentiation. These findings indicate that a common metabolite can regulate the balance between pro- and anti-inflammatory immunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mucida, Daniel -- Park, Yunji -- Kim, Gisen -- Turovskaya, Olga -- Scott, Iain -- Kronenberg, Mitchell -- Cheroutre, Hilde -- R01 AI050265-06/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2007 Jul 13;317(5835):256-60. Epub 2007 Jun 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569825" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cells, Cultured
;
Colitis/immunology
;
Dendritic Cells/immunology
;
Dibenzazepines/pharmacology
;
Forkhead Transcription Factors/biosynthesis
;
Interleukin-17/*biosynthesis
;
Interleukin-2/immunology
;
Interleukin-6/immunology
;
Intestinal Mucosa/cytology/immunology
;
Listeriosis/immunology
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Spleen/cytology/immunology
;
T-Lymphocyte Subsets/cytology/*immunology
;
T-Lymphocytes, Helper-Inducer/cytology/*immunology
;
T-Lymphocytes, Regulatory/cytology/*immunology
;
Transforming Growth Factor beta/metabolism/pharmacology
;
Tretinoin/pharmacology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
