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  • 1
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    Evolvability and hierarchy in rewired bacterial gene networks (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-04-19
    Description: Sequencing DNA from several organisms has revealed that duplication and drift of existing genes have primarily moulded the contents of a given genome. Though the effect of knocking out or overexpressing a particular gene has been studied in many organisms, no study has systematically explored the effect of adding new links in a biological network. To explore network evolvability, we constructed 598 recombinations of promoters (including regulatory regions) with different transcription or sigma-factor genes in Escherichia coli, added over a wild-type genetic background. Here we show that approximately 95% of new networks are tolerated by the bacteria, that very few alter growth, and that expression level correlates with factor position in the wild-type network hierarchy. Most importantly, we find that certain networks consistently survive over the wild type under various selection pressures. Therefore new links in the network are rarely a barrier for evolution and can even confer a fitness advantage.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666274/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666274/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Isalan, Mark -- Lemerle, Caroline -- Michalodimitrakis, Konstantinos -- Horn, Carsten -- Beltrao, Pedro -- Raineri, Emanuele -- Garriga-Canut, Mireia -- Serrano, Luis -- 066543/Wellcome Trust/United Kingdom -- England -- Nature. 2008 Apr 17;452(7189):840-5. doi: 10.1038/nature06847.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), UPF, 08003 Barcelona, Spain. isalan@crg.es〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18421347" target="_blank"〉PubMed〈/a〉
    Keywords: Escherichia coli/*genetics/growth & development/*metabolism ; Escherichia coli Proteins/genetics/metabolism ; *Evolution, Molecular ; Gene Expression Regulation, Bacterial/*genetics ; Gene Regulatory Networks/*genetics ; Genes, Bacterial/genetics ; *Genetic Engineering ; Heat-Shock Response ; Oligonucleotide Array Sequence Analysis ; Open Reading Frames/genetics ; Promoter Regions, Genetic/genetics ; *Selection, Genetic ; Serial Passage ; Sigma Factor/genetics/metabolism ; Transcription Factors/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Do female hyaenas choose mates based on tenure? (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-07-11
    Description: In their investigation into whether female mate-choice drives male dispersal, Honer et al. argue that female spotted hyaenas (Crocuta crocuta) prefer mates whose tenure in the social group is less than the females' age, to avoid paternal incest, and suggest that male dispersal reflects this preference. However, we are not persuaded that females choose mates on the basis of tenure because Honer et al. overlook the alternative hypothesis that dispersal status itself is important in female mate-choice, such that females prefer immigrants over natal males. Like mate-choice based on tenure, choice based on dispersal status reduces the risk of incest.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Van Horn, Russell C -- Watts, Heather E -- Holekamp, Kay E -- England -- Nature. 2008 Jul 10;454(7201):E1; discussion E2. doi: 10.1038/nature07122.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Zoological Society of San Diego, Conservation and Research for Endangered Species, P.O. Box 120551, San Diego, California 92112-0551, USA. rvanhorn@sandiegozoo.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18615020" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Female ; Hyaenidae/*physiology ; Inbreeding ; Male ; Mating Preference, Animal/*physiology ; Reproducibility of Results ; Social Behavior ; Time Factors
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    Wandering minds: the default network and stimulus-independent thought (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-01-20
    Description: Despite evidence pointing to a ubiquitous tendency of human minds to wander, little is known about the neural operations that support this core component of human cognition. Using both thought sampling and brain imaging, the current investigation demonstrated that mind-wandering is associated with activity in a default network of cortical regions that are active when the brain is "at rest." In addition, individuals' reports of the tendency of their minds to wander were correlated with activity in this network.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821121/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1821121/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, Malia F -- Norton, Michael I -- Van Horn, John D -- Wegner, Daniel M -- Grafton, Scott T -- Macrae, C Neil -- MH49127/MH/NIMH NIH HHS/ -- R01 NS033504/NS/NINDS NIH HHS/ -- R01 NS050614/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2007 Jan 19;315(5810):393-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA. malia@nmr.mgh.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17234951" target="_blank"〉PubMed〈/a〉
    Keywords: Attention ; Brain Mapping ; Cerebral Cortex/*physiology ; Cognition ; Fantasy ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Nerve Net/physiology ; Thinking/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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