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  • 1
    Electronic Resource
    Electronic Resource
    Chirality influences the biological activity of the sex pheromones of the khapra beetle (1979)
    Springer
    Naturwissenschaften 66 (1979), S. 211-211 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00366032
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  • 2
    Electronic Resource
    Electronic Resource
    A primary exposure standard for X-rays in the (30÷150) keV range (1984)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 4 (1984), S. 382-396 
    Details
    ISSN: 0392-6737
    Keywords: Measurement of basic quantities ; Medical and biomedical uses of fields ; radiations and radioactivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto Si descrive il campione primario dell'unità di esposizione per raggi X di media energia dell'Istituto Superiore di Sanità (ISS), con particolare attenzione ad alcuni dettagli innovativi. Si discutono le metodiche d'intercalibrazione tra campioni primari di esposizione di diversi laboratori metrologici primari. Sono infine presentati i risultati di un confronto effettuato nel 1983 tra il campione primario di esposizione dell'ISS e l'analogo campione del Bureau International des Poids et Mesures.
    Abstract: Резюме Описывается первичный эталон экспозиции для рентгеновских лучей промежуточных энергий, предложенный Высщим институтом здравоохраненуя Италии. Особое внимание уделяется некоторым новым техническим деталам. Обсуждаются методы взаимной калибровки эталонов экспозиции из различных националъных метрологических лабораторий. В заключение приводятся результаты сравнения первичного эталона экспозиции Высщего института здравоохранения и первичного эталона экспозиции Международного Ъюро Мер и Весов, которое было проведено в 1983 году.
    Notes: Summary The primary exposure standard for medium-energy X-rays of the Istituto Superiore di Sanità (ISS) is described with particular attention to some innovatory details. Methods for intercalibrating exposure standards from various national primary-standard laboratories are discussed. The results of a comparison between the ISS exposure standard and that of the Bureau International des Poids et Mesures performed in 1983 are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02451295
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  • 3
    Electronic Resource
    Electronic Resource
    Measurement of ultraweak chemiluminescence emitted from isolated and perfused rat hearts (1984)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 3 (1984), S. 936-944 
    Details
    ISSN: 0392-6737
    Keywords: Biophysical instrumentation and techniques
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Description / Table of Contents: Riassunto È stato usato un apparato di misurazione a un fotone per misurare la chemiluminescenza emessa durante la perossidazione dei fosfolipidi della membrana cellulare di un cuore di ratto isolato e perfuso sottoposto ad uno stress perossidativo. Lo stress perossidativo è stato ottenuto aggiungendo idroperossidi al liquido di perfusione. I differenti idroperossidi usati hanno prodotto tipiche evoluzioni temporali di chemi-luminescenza altamente riproducibili. La disponibilità di ossigeno influenza fortemente l'intensità e la cinetica di emissione della chemiluminescenza. Nell'àmbito di uno studio sull'effetto di differenti idroperossidi sul cuore di ratto isolato e perfuso, la misura della chemiluminescenza si è dimostrata un interessante e promettente strumento per il monitoraggio in continuo dei danni perossidativi nelle membrane biologiche. La sensibilità di questo metodo per la valutazione della perossidazione dei fosfolipidi delle biomembrane è circa dieci volte maggiore rispetto agli ordinari metodi di chimica analitica.
    Abstract: Резюме В этой статъе описывается аппаратура для ретистрации отделъных фотонов для непрерывного мониторнта улътраслабой хемилюминесценции, испус-каемой во время пероксидации фосфолипидов клеточной мембраны изолированного и перфузированного сердца крысы. В частности, аппаратура для ретистрации отделъ-ных фотонов исполъзуется для оценки напряжениь, индуцированных в сердце при добавлении тидроперекиси в пербузирующую жидкостъ. для этого исполъзуутся различные тидропероксиды, которые дают типичные временные эволюции улътса-слабой хемиюминесценции. Также получается, что наличие кислорода силъно влияет на интенсивиостъ и кинетику улътраслабои хемилюминесценции. Показывается, что улътраслабая хемилюминесценция представляет оченъ интересный и перспективный инструмент для мониторинга пероксидативных повреждений биологических мембран. Чувствителъностъ этого метода для пценки пероксидации босболинидов биомембран почти в десятъ раз выше, чем обычнын методов аналитической химии.
    Notes: Summary This paper describes the use of a single-photon counting apparatus (SPCA) for the continuous monitoring of the ultraweak chemiluminescence (UWC) emitted by isolated and perfused rat hearts and deriving from phospholipid peroxydation. Specifically the SPCA was used to assess the peroxidative stress induced in the heart by the addition of an hydroperoxide to the perfusing medium. To this purpose, different hydroperoxides were used and each one produced a tipical and highly reliable temporal evolution of UWC. It was also found that the oxygen availability strongly influences the intensity and the kinetic of the UWC emission. UWC was proved to be a very interesting and promising tool for monitoring the peroxidative damage of biological membranes, both because it makes a continuous assessment possible and because the sensitivity of this method is approximately ten times greater than usual analytical chemistry methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02457093
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  • 4
    Electronic Resource
    Electronic Resource
    Development of a population pharmacokinetic database for tianeptine (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 173-179 
    Details
    ISSN: 1432-1041
    Keywords: Tianeptine ; anti-depressant ; NONMEM ; population pharmacokinetic ; pre-marketing database
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Two thousand three hundred and thirty five plasma concentrations of tianeptine from 112 patients enrolled in nine studies of tianeptine pharmacokinetics performed prior to the marketing of the drug were pooled for analysis using mixed-effect modeling. Studies represented a combination of single dose and multiple dosing at steady-state. Tianeptine plasma concentration time data were fit to a two compartment model with first order absorption using the NONMEM computer program. The results of this analysis suggested that alcoholism is associated with significant increase in clearance (124% increase) and volume of the central compartment (161% increase). The volume of the peripheral compartment is significantly lower in women (31% decrease) and in depressed patients (59% decrease). The population mean (interindividual variability) clearance was equal to 0.17 l·h−1·kg−1 (28.6%), the volume of central compartment was 0.13 l·kg−1 (60.4%), intercompartmental clearance was 0.07 l·h−1·kg−1 (30.1%), volume of the tissue compartment was 1.17 l·kg−1 (28.3%), and the absorption rate constant was 0.63 h−1 (21.8%). The residual variability was approximately 30% at concentrations expected during clinical use of the drug. Because of the increased clearance, alcoholic patients would be expected to have significantly reduced concentrations during steady-state dosing. These population parameters provide a basis for developing initial dosing recommendations and for performing bayesian evaluations of drug concentrations obtained in post-marketing studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315502
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  • 5
    Electronic Resource
    Electronic Resource
    Predictive performance of population pharmacokinetic parameters of tianeptine as applied to plasma concentrations from a post-marketing study (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 123-128 
    Details
    ISSN: 1432-1041
    Keywords: Tianeptine ; anti-depressant ; population pharmacokinetic ; prediction error
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The predictive ability of population pharmacokinetic parameters of tianeptine, obtained from a mixed effect analysis of pre-marketing pharmacokinetic studies, was evaluated using tianeptine plasma concentrations obtained during a large multi-center post-marketing surveillance study. The mean prediction error was 7.8 ng·ml−1 and the root mean square prediction error was 52.1 ng/ml when initial estimates of population pharmacokinetic parameters were used to predict drug concentrations in one half of the post-marketing data. When the population parameters were revised to reflect the data collected in the first half of the post-marketing study, the mean prediction error was reduced to −3.2 ng·ml−1 and the root mean square prediction error was reduced to 29.5 ng·ml−1. These results suggest that population pharmacokinetic parameters obtained from pre-marketing data may not accurately predict drug concentrations in patients receiving the drug in the post-marketing setting. Once the population parameters are updated to reflect data from the post-marketing period, the predictive ability of the database increases, but substantial variability in the prediction error remains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315492
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  • 6
    Electronic Resource
    Electronic Resource
    Solutions to linear equations depending on a parameter (1996)
    Springer
    Decisions in economics and finance 19 (1996), S. 103-112 
    Details
    ISSN: 1129-6569
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Description / Table of Contents: Riassunto Si fornisce un'analisi delle relazioni fra le soluzioni di un sistema di equazioni lineari che dipendono da un parametro. I risultati ottenuti sono poi applicati a un problema economico riguardante i prezzi: In base alla formalizzazione classica, i prezzi di produzione dipendono dalla tecnica e da un parametro, il tasso di profitto, che rappresenta la distribuzione.
    Notes: Abstract An analysis of the relationships between the solutions of a system of linear equations depending on a parameter is provided. The results are applied to an economic problem concerning prices: According to the classical formalisation, the prices of production depend on the technique and a parameter, the rate of profit, representing distribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441264
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  • 7
    Electronic Resource
    Electronic Resource
    Mesitylene solvated platinum atoms in the preparation of efficient supported catalysts for the dehydrogenation of methylcyclohexane to toluene (1993)
    Springer
    Catalysis letters 17 (1993), S. 151-155 
    Details
    ISSN: 1572-879X
    Keywords: Platinum atoms ; platinum deposition ; methylcyclohexane dehydrogenation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Mesitylene solvated platinum atoms have been conveniently used for the deposition of active Pt particles on γ-Al2O3 supports. The so prepared catalysts have been compared with traditionally obtained Pt/γ-Al2O3 catalysts in the dehydrogenation of methylcyclohexane to toluene, at 200 and 250 °C, showing, at low Pt loadings, a much greater specific activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00763937
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  • 8
    Electronic Resource
    Electronic Resource
    Pt/γ-Al2O3 catalytic membranes vs. Pt on γ-Al2O3 powders in the selective hydrogenation of p-chloronitrobenzene (1997)
    Springer
    Catalysis letters 44 (1997), S. 205-210 
    Details
    ISSN: 1572-879X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The catalytic activity of Pt/γ-Al2O3 membrane reactors, prepared using mesitylene solvated platinum atoms as source of active Pt particles, has been compared with that of analogously obtained Pt/γ-Al2O3 powders in the liquid phase hydrogenation of p-chloronitrobenzene. A largely different behaviour has been observed, the membrane reactor acting as a H2 richer system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018989428197
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  • 9
    Electronic Resource
    Electronic Resource
    Universal multifractal approach to intermittency in high energy physics (1994)
    Springer
    The European physical journal 61 (1994), S. 229-237 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A new stochastic approach to intermittency in high energy physics is proposed. It yields to intermittency exponents defined independently of phase-space dimensions; their role in the calculation of generalized moments is discussed. A straightforward application of universal multifractals is suggested and a new parametric technique for phase-space analysis is provided.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01413100
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  • 10
    Electronic Resource
    Electronic Resource
    Porous Pt/γ-Al2O3 catalytic membrane reactors prepared using mesitylene solvated Pt atoms (1993)
    Springer
    Catalysis letters 20 (1993), S. 287-297 
    Details
    ISSN: 1572-879X
    Keywords: Membrane reactors ; inorganic membranes ; organic precursors ; solvated platinum atoms ; benzene hydrogenation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The opportunity of using mesitylene solvated Pt atoms for the deposition of Pt catalyst on inorganic membranes is shown. The catalytic activity of the membrane reactor has been tested using the hydrogenation of benzene as model reaction. The performance of the membrane reactor has been compared with that of a conventional packed bed using γ-Al2O3 powder impregnated with Pt. The effect of the feeding configuration has been investigated, and the results show a membrane effect due to the different degrees of accessibility of pores of different size. For alumina powder we have obtained an activation energy of 12.9 kcal/mol, which well agrees with the data reported in literature. The membrane reactor, instead, exhibited an activation energy ca. 60% lower. The preliminary porometry results have shown a slight effect of the platinum deposition process on membrane permeability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00769301
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