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  • Earth Resources and Remote Sensing  (7)
  • Humans  (4)
  • GEOPHYSICS  (3)
  • Cell & Developmental Biology  (2)
  • INSTRUMENTATION AND PHOTOGRAPHY
  • 2005-2009  (9)
  • 1975-1979  (9)
  • 1
    Digitale Medien
    Digitale Medien
    The role of adenosine 3′,5′-monophosphate in the transformation of cloudman mouse melanoma cells (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 86 (1975), S. 543-551 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The role of adenosine 3′,5′-monophosphate (cyclic AMP) in the regulation of mouse melanoma cell growth and differentiation was investigated. A variant melanoma (Cloudman S91-F) which displays a greater degree of transformation than the parental cell (Cloudman S91) was isolated. A correlation between cyclic AMP metabolism and transformation was made. Dibutyryl cyclic AMP depressed cell growth and increased pigmentation in both parental and variant cell lines. The parental cell line, however, was more responsive to melanocyte-stimulating hormone (MSH) which was found to affect cell growth and pigmentation by increasing cyclic AMP levels. The more transformed S91-F cell line contained lower levels of cyclic AMP than the parental cell line, and this fact correlated well with the higher degree of growth and lesser degree of pigmentation in the variant. Enzymatic analysis revealed that the hydrolysis of cyclic AMP in both cell lines was similar, while the adenylate cyclase activity of the variant cell line was lower than that of the parental cell line. Lineweaver-Burk plots demonstrated that the Km′s for the enzymes in the two cell lines were the same but that the Vmax of the S91-F cell line was significantly less than that of the S91 cell line. Thus, the lesion in the S91-F cell which is responsible for its more transformed characteristics seems to be one which affects adenylate cyclase at the level of the cell membrane.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1040860311
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 2
    Digitale Medien
    Digitale Medien
    Interaction of two mechanisms regulating alkali cations in hela cellsResearch jointly sponsored by the National Cancer Institute and by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation. (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 86 (1975), S. 59-70 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The alkali cation content of HeLa cells is independent of culture density and of whether the cells are grown in suspension or attached to the culture vessel. With a cell doubling time of 28 hours, the cell K content turns over approximately once per hour. Following partial blockade of the alkali-cation transport system with ouabain, two distinct but interrelated mechanisms operate in the cellular response: (a) an increase in intracellular Na stimulates the pump so that the short-term alteration in electrolyte composition is less than would be expected from the fraction of pump sites inhibited, and (b) there is a cyclo-heximide-sensitive recovery in transport capacity reflecting a restoration of functional transport sites to their normal density on the cell surface. Experimental manipulations that mimic the effect of ouabain lead to a stimulation of transport, but they do not result in an increase in the number of ouabain-binding sites on the surface. The data are consistent with a four-to-six-hour turnover of transport sites at the surface, but there is no evidence for a specific induction of the transport system within this short-term recovery period.
    Zusätzliches Material: 7 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1040860108
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 3
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    Painless deprivation (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2009-05-23
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaughan, William Jr -- New York, N.Y. -- Science. 2009 May 22;324(5930):1014. doi: 10.1126/science.324_1014b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Casco Courseware, LLC, 207 South Road, Chebeague Island, ME 04017, USA. wvaughan@chebeague.net〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19460984" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Brain/*physiology ; *Emotions ; Humans ; *Pain ; Pleasure-Pain Principle
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Problems with genome-wide association studies (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-06-30
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shriner, Daniel -- Vaughan, Laura K -- Padilla, Miguel A -- Tiwari, Hemant K -- New York, N.Y. -- Science. 2007 Jun 29;316(5833):1840-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17600199" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Genetic Predisposition to Disease ; Genetic Testing ; *Genetics, Medical/methods ; Genetics, Population ; *Genome, Human ; Humans ; *Polymorphism, Single Nucleotide
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Serum lipoprotein concentrations in cystic fibrosis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-02-17
    Beschreibung: Two major classes of lipoproteins, low density and high density, are decreased in the serum of patients with cystic fibrosis; major apoproteins are also decreased. Since essential fatty acids and certain fat-soluble vitamins depend on lipoproteins for transport in the serum, knowledge of lipoprotein levels in cystic fibrosis patients could prove valuable in understanding (i) the basis for the abnormally low serum levels of these fatty acids and vitamins and (ii) the effects of therapies involving these molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Vaughan, W J -- Lindgren, F T -- Whalen, J B -- Abraham, S -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):783-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203033" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Carrier State/blood ; Child ; Child, Preschool ; Cystic Fibrosis/*blood ; Electrophoresis, Agar Gel ; Electrophoresis, Polyacrylamide Gel ; Female ; Humans ; Lipoproteins/*blood ; Lipoproteins, HDL/blood ; Lipoproteins, LDL/blood ; Lipoproteins, VLDL/blood ; Male
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    A brain event related to the making of a sensory discrimination (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1979-03-30
    Beschreibung: Event-related potentials associated with detected targets in a vigilance task were analyzed in two ways: (i) by sorting the potentials in terms of sequential reaction time bins of 50 milliseconds and (ii) by examining the single trial waveforms. A negative component (N2) covaried in latency with reaction time. These results support the hypothesis that N2 reflects a decision process which controls behavioral responses in sensory discrimination tasks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ritter, W -- Simson, R -- Vaughan, H G Jr -- Friedman, D -- New York, N.Y. -- Science. 1979 Mar 30;203(4387):1358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424760" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Behavior/physiology ; Brain/*physiology ; Cognition/physiology ; Discrimination (Psychology)/*physiology ; Evoked Potentials ; Humans ; Pitch Discrimination/physiology ; Time Factors
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Experiments on atmospheric processes (1977)
    In:  CASI
    Details
    Publikationsdatum: 2016-06-07
    Beschreibung: Spacelab technology is examined as applied to the observation of the earth's weather patterns, composition, thermodynamics, and kinematics. An atmospheric cloud physics laboratory and a geophysical fluid flow cell are individually outlined as planned payload experiment efforts.
    Schlagwort(e): GEOPHYSICS
    Materialart: Proc. of the ASPE(MSFC Symp. on Eng. and Productivity Gains from Space Technol.; p 183-193
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 8
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    Extraction of quadrature phase information from multiple pulse NMR signals (1976)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: A multiple pulse sequence (8-pulse sequence) used for high-resolution solid state NMR is analyzed with regard to the information available from each of the four wide sampling windows. It is demonstrated that full quadrature phase information can be obtained using only a single phase detector and that, for the commonly encountered situation where the spectral width is much less than the folding frequency, the signals from the various windows can be combined easily using standard complex Fourier transform software. An improvement in the signal-to-noise ratio equal to the square root of 3 is obtained over either standard single or quadrature phase detection schemes. Procedures for correcting spectral distortions are presented.
    Schlagwort(e): INSTRUMENTATION AND PHOTOGRAPHY
    Materialart: Review of Scientific Instruments; 47; June 197
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 9
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    Initial Verification of GEOS-4 Aerosols Using CALIPSO and MODIS: Scene Classification (2007)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-19
    Beschreibung: A-train sensors such as MODIS and MISR provide column aerosol properties, and in the process a means of estimating aerosol type (e.g. smoke vs. dust). Correct classification of aerosol type is important because retrievals are often dependent upon selection of the right aerosol model. In addition, aerosol scene classification helps place the retrieved products in context for comparisons and analysis with aerosol transport models. The recent addition of CALIPSO to the A-train now provides a means of classifying aerosol distribution with altitude. CALIPSO level 1 products include profiles of attenuated backscatter at 532 and 1064 nm, and depolarization at 532 nm. Backscatter intensity, wavelength ratio, and depolarization provide information on the vertical profile of aerosol concentration, size, and shape. Thus similar estimates of aerosol type using MODIS or MISR are possible with CALIPSO, and the combination of data from all sensors provides a means of 3D aerosol scene classification. The NASA Goddard Earth Observing System general circulation model and data assimilation system (GEOS-4) provides global 3D aerosol mass for sulfate, sea salt, dust, and black and organic carbon. A GEOS-4 aerosol scene classification algorithm has been developed to provide estimates of aerosol mixtures along the flight track for NASA's Geoscience Laser Altimeter System (GLAS) satellite lidar. GLAS launched in 2003 and did not have the benefit of depolarization measurements or other sensors from the A-train. Aerosol typing from GLAS data alone was not possible, and the GEOS-4 aerosol classifier has been used to identify aerosol type and improve the retrieval of GLAS products. Here we compare 3D aerosol scene classification using CALIPSO and MODIS with the GEOS-4 aerosol classifier. Dust, smoke, and pollution examples will be discussed in the context of providing an initial verification of the 3D GEOS-4 aerosol products. Prior model verification has only been attempted with surface mass comparisons and column optical depth from AERONET and MODIS.
    Schlagwort(e): Earth Resources and Remote Sensing
    Materialart: A-train Symposium in Lille; Oct 22, 2007 - Oct 25, 2007; Lille; France
    Format: text
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    NASA TECHNICAL REPORTS
  • 10
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    Thermal Band Atmospheric Correction Using Atmospheric Profiles Derived from Global Positioning System Radio Occultation and the Atmospheric Infrared Sounder (2006)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-07-19
    Beschreibung: This Rapid Prototyping Capability study explores the potential to use atmospheric profiles derived from GPS (Global Positioning System) radio occultation measurements and by AIRS (Atmospheric Infrared Sounder) onboard the Aqua satellite to improve surface temperature retrieval from remotely sensed thermal imagery. This study demonstrates an example of a cross-cutting decision support technology whereby NASA data or models are shown to improve a wide number of observation systems or models. The ability to use one data source to improve others will be critical to the GEOSS (Global Earth Observation System of Systems) where a large number of potentially useful systems will require auxiliary datasets as input for decision support. Atmospheric correction of thermal imagery decouples TOA radiance and separates surface emission from atmospheric emission and absorption. Surface temperature can then be estimated from the surface emission with knowledge of its emissivity. Traditionally, radiosonde sounders or atmospheric models based on radiosonde sounders, such as the NOAA (National Oceanic & Atmospheric Administration) ARL (Air Resources Laboratory) READY (Real-time Environmental Application and Display sYstem), provide the atmospheric profiles required to perform atmospheric correction. Unfortunately, these types of data are too spatially sparse and too infrequently taken. The advent of high accuracy, global coverage, atmospheric data using GPS radio occultation and AIRS may provide a new avenue for filling data input gaps. In this study, AIRS and GPS radio occultation derived atmospheric profiles from the German Aerospace Center CHAMP (CHAllenging Minisatellite Payload), the Argentinean Commission on Space Activities SAC-C (Satellite de Aplicaciones Cientificas-C), and the pair of NASA GRACE (Gravity Recovery and Climate Experiment) satellites are used as input data in atmospheric radiative transport modeling based on the MODTRAN (MODerate resolution atmospheric TRANsmittance) radiative transport software to separate out the atmospheric component of measured top of atmosphere radiance. Simulated water bodies across a variety of MODTRAN model atmospheres including desert, mid-latitude, tropical and sub-artic conditions provide test bed conditions. Atmospherically corrected radiance and surface temperature results were compared to those obtained using traditional radiosonde balloon data and models. In general, differences between the different techniques were less than 2 percent indicating the potential value satellite derived atmospheric profiles have to atmospherically correct thermal imagery.
    Schlagwort(e): Earth Resources and Remote Sensing
    Materialart: SSTI-2220-0092
    Format: text
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    NASA TECHNICAL REPORTS
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