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  • 2005-2009  (116)
  • 1975-1979  (26)
  • 1950-1954  (25)
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  • 1
    Electronic Resource
    Electronic Resource
    Quantitative Analysis of Variability and Uncertainty with Known Measurement Error: Methodology and Case Study (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Risk analysis 25 (2005), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The appearance of measurement error in exposure and risk factor data potentially affects any inferences regarding variability and uncertainty because the distribution representing the observed data set deviates from the distribution that represents an error-free data set. A methodology for improving the characterization of variability and uncertainty with known measurement errors in data is demonstrated in this article based on an observed data set, known measurement error, and a measurement-error model. A practical method for constructing an error-free data set is presented and a numerical method based upon bootstrap pairs, incorporating two-dimensional Monte Carlo simulation, is introduced to address uncertainty arising from measurement error in selected statistics. When measurement error is a large source of uncertainty, substantial differences between the distribution representing variability of the observed data set and the distribution representing variability of the error-free data set will occur. Furthermore, the shape and range of the probability bands for uncertainty differ between the observed and error-free data set. Failure to separately characterize contributions from random sampling error and measurement error will lead to bias in the variability and uncertainty estimates. However, a key finding is that total uncertainty in mean can be properly quantified even if measurement and random sampling errors cannot be separated. An empirical case study is used to illustrate the application of the methodology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.2005.00620.x
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  • 2
    Electronic Resource
    Electronic Resource
    Sensitivity Analysis of a Two-Dimensional Probabilistic Risk Assessment Model Using Analysis of Variance (2005)
    350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2DQ , UK . : Blackwell Publishing, Inc.
    Risk analysis 25 (2005), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: This article demonstrates application of sensitivity analysis to risk assessment models with two-dimensional probabilistic frameworks that distinguish between variability and uncertainty. A microbial food safety process risk (MFSPR) model is used as a test bed. The process of identifying key controllable inputs and key sources of uncertainty using sensitivity analysis is challenged by typical characteristics of MFSPR models such as nonlinearity, thresholds, interactions, and categorical inputs. Among many available sensitivity analysis methods, analysis of variance (ANOVA) is evaluated in comparison to commonly used methods based on correlation coefficients. In a two-dimensional risk model, the identification of key controllable inputs that can be prioritized with respect to risk management is confounded by uncertainty. However, as shown here, ANOVA provided robust insights regarding controllable inputs most likely to lead to effective risk reduction despite uncertainty. ANOVA appropriately selected the top six important inputs, while correlation-based methods provided misleading insights. Bootstrap simulation is used to quantify uncertainty in ranks of inputs due to sampling error. For the selected sample size, differences in F values of 60% or more were associated with clear differences in rank order between inputs. Sensitivity analysis results identified inputs related to the storage of ground beef servings at home as the most important. Risk management recommendations are suggested in the form of a consumer advisory for better handling and storage practices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.2005.00679.x
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  • 3
    Electronic Resource
    Electronic Resource
    The involvement of the 3′:5′-cyclic-AMP phosphodiesterase in transformation and growth of crown-gall tumors in Bryophyllum daigremontianum (1977)
    Springer
    Planta 137 (1977), S. 165-168 
    Details
    ISSN: 1432-2048
    Keywords: Bryophyllum ; Crown-gall ; 3′:5′-cyclic-AMP phosphodiesterase ; Theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In crown-gall tumor tissue obtained from leaves of Bryophyllum daigremontianum an adenosine 3′:5′-cyclic phosphate (3′:5′-cyclic-AMP) degrading activity increases up to 2.5 fold until the fifth day after inoculation with Agrobacterium tumefaciens, declining to the value of the control in the solid tumor. Theophylline up to 1 mmol l−1 given to wounded leaves of Bryophyllum daigremontianum has no effect on the number of tumors. The effect of higher concentrations given over extended periods can be explained otherwise. Therefore it seems likely that the 3′:5′-cyclic-AMP phosphodiesterase (EC 3.1.4.17) has no effect on transformation and growth of crown-gall tumors in Bryophyllum daigremontianum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387554
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  • 4
    Electronic Resource
    Electronic Resource
    Bioavailability of oral testosterone in males (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 345-349 
    Details
    ISSN: 1432-1041
    Keywords: testosterone ; testosterone undecanoate ; arachis oil ; serum level ; oral administration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Twenty-six male volunteers received a single oral dose of testosterone as free crystals or as the undecanoate ester. The latter was given either in crystalline form or in arachis oil. All preparations were tested three times in the same individual, whilst fasting on 2 days and on one day together with a breakfast rich in fat. Serum testosterone concentration was measured at intervals for up to 6–24h after the dose. A significant and reproducible rise in serum testosterone level was found after ingestion of free testosterone. Testosterone esterified with undecylenic acid was only effective when administered in arachis oil. The meal increased the bioavailability of the ester, but had hardly any effect on that of the free hormone. It is concluded that bioavailability of oral testosterone can be improved by pharmaceutical means to an extent sufficient to produce adequate blood levels in substitution therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00605634
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  • 5
    Electronic Resource
    Electronic Resource
    Carbamazepine and its 10,11-epoxide in children and adults with epilepsy (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 129-133 
    Details
    ISSN: 1432-1041
    Keywords: carbamazepine ; carbamazepine-10,11-epoxide ; plasma concentration ; CSF concentration ; children ; adult
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma concentrations of carbamazepine and its 10,11-epoxide were measured in 37 children and 13 adults with epilepsy during maintenance therapy. The children formed relatively more of the epoxy metabolite than adults. The daily dose, expressed as mg/kg or mg/m2, showed a statistically significant correlation with blood level in children, but not in adults. The cerebrospinal fluid concentrations of carbamazepine and carbamazepine-10,11-epoxide in nine children were 33 and 41 per cent, respectively, of the concomitant plasma level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00562904
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  • 6
    Electronic Resource
    Electronic Resource
    Untersuchung von Kautschuk (1953)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 58-62 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434849
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  • 7
    Electronic Resource
    Electronic Resource
    Über die Verfahren zur Sulfatbestimmung als Bariumsulfat (1953)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 53-53 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434839
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  • 8
    Electronic Resource
    Electronic Resource
    Zink (1953)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 138 (1953), S. 131-133 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00460881
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  • 9
    Electronic Resource
    Electronic Resource
    Bei der Bestimmung von Zink, Zinkoxyd und Zinkchlorid in Galvanisierrückständen (1953)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 58-58 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434848
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  • 10
    Electronic Resource
    Electronic Resource
    Für die Bestimmung von Kautschuk-Kohlenwasserstoff (1953)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 139 (1953), S. 378-378 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00435036
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