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  • 1
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    Essential role for Nix in autophagic maturation of erythroid cells (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-06
    Description: Erythroid cells undergo enucleation and the removal of organelles during terminal differentiation. Although autophagy has been suggested to mediate the elimination of organelles for erythroid maturation, the molecular mechanisms underlying this process remain undefined. Here we report a role for a Bcl-2 family member, Nix (also called Bnip3L), in the regulation of erythroid maturation through mitochondrial autophagy. Nix(-/-) mice developed anaemia with reduced mature erythrocytes and compensatory expansion of erythroid precursors. Erythrocytes in the peripheral blood of Nix(-/-) mice exhibited mitochondrial retention and reduced lifespan in vivo. Although the clearance of ribosomes proceeded normally in the absence of Nix, the entry of mitochondria into autophagosomes for clearance was defective. Deficiency in Nix inhibited the loss of mitochondrial membrane potential (DeltaPsi(m)), and treatment with uncoupling chemicals or a BH3 mimetic induced the loss of DeltaPsi(m) and restored the sequestration of mitochondria into autophagosomes in Nix(-/-) erythroid cells. These results suggest that Nix-dependent loss of DeltaPsi(m) is important for targeting the mitochondria into autophagosomes for clearance during erythroid maturation, and interference with this function impairs erythroid maturation and results in anaemia. Our study may also provide insights into molecular mechanisms underlying mitochondrial quality control involving mitochondrial autophagy.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570948/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570948/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sandoval, Hector -- Thiagarajan, Perumal -- Dasgupta, Swapan K -- Schumacher, Armin -- Prchal, Josef T -- Chen, Min -- Wang, Jin -- F31 AI058932/AI/NIAID NIH HHS/ -- R01 AI056210/AI/NIAID NIH HHS/ -- R01 AI056210-05/AI/NIAID NIH HHS/ -- R01 AI074949/AI/NIAID NIH HHS/ -- R01 AI074949-01/AI/NIAID NIH HHS/ -- R01 GM087710/GM/NIGMS NIH HHS/ -- England -- Nature. 2008 Jul 10;454(7201):232-5. doi: 10.1038/nature07006. Epub 2008 May 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18454133" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apoptosis/drug effects ; *Autophagy/drug effects ; Biphenyl Compounds/pharmacology ; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology ; Cell Survival/drug effects ; Embryonic Stem Cells/cytology/drug effects ; Erythroid Cells/*cytology/drug effects/*metabolism ; *Erythropoiesis/drug effects ; Membrane Proteins/deficiency/genetics/*metabolism ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects/metabolism/pathology ; Mitochondrial Proteins/deficiency/genetics/*metabolism ; Nitrophenols/pharmacology ; Piperazines/pharmacology ; Reticulocytes/cytology/drug effects/metabolism ; Sulfonamides/pharmacology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Dendritic cell apoptosis in the maintenance of immune tolerance (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-02-25
    Description: Apoptosis in the immune system is critical for maintaining self-tolerance and preventing autoimmunity. Nevertheless, inhibiting apoptosis in lymphocytes is not alone sufficient to break self-tolerance, suggesting the involvement of other cell types. We investigated whether apoptosis in dendritic cells (DCs) helps regulate self-tolerance by generating transgenic mice expressing the baculoviral caspase inhibitor, p35, in DCs (DC-p35). DC-p35 mice displayed defective DC apoptosis, resulting in their accumulation and, in turn, chronic lymphocyte activation and systemic autoimmune manifestations. The observation that a defect in DC apoptosis can independently lead to autoimmunity is consistent with a central role for these cells in maintaining immune self-tolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Min -- Wang, Yui-Hsi -- Wang, Yihong -- Huang, Li -- Sandoval, Hector -- Liu, Yong-Jun -- Wang, Jin -- New York, N.Y. -- Science. 2006 Feb 24;311(5764):1160-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA. minc@bcm.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16497935" target="_blank"〉PubMed〈/a〉
    Keywords: Adoptive Transfer ; Aging ; Animals ; Antibodies, Antinuclear/analysis ; *Apoptosis ; *Autoimmunity ; B-Lymphocytes/immunology ; Caspase Inhibitors ; Cell Survival ; Dendritic Cells/*immunology/*physiology ; Kidney/immunology ; Lung/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; *Self Tolerance ; Spleen/immunology ; T-Lymphocytes/immunology ; Viral Proteins/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
    Electronic Resource
    Electronic Resource
    The time-resolved spectrum of a pulsed dye laser (1984)
    Springer
    Optical and quantum electronics 16 (1984), S. 393-398 
    Details
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Notes: Abstract The spectral evolution in a xenon ion-pumped open dye stream laser was measured and analysed in terms of a theoretical spectro-temporal relation previously derived. Sweep occurs in a 200 ns time scale and simultaneous oscillations of several wavelengths can be achieved by varying laser cavity parameters. Experiments were completely reproduced by assuming that the phenomena can be ascribed to the homogeneous broadening of the laser fluorescent band.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00619630
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  • 4
    Electronic Resource
    Electronic Resource
    Isolation and physical characterization of plasmid pCCl from Corynebacterium callunae and construction of hybrid derivatives (1984)
    Springer
    Applied microbiology and biotechnology 19 (1984), S. 409-413 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The corynebacteria seem to be the most suitable microorganisms for cloning genes involved in the production of amino acids, nucleotides, and other products of industrial interest. A plasmid, pCCl, from Corynebacterium callunae has been found with a size of 4.3 kb. A physical map obtained with restriction endonucleases is presented. pCCl has single restriction sites for Kpn I, Sma I, Bal I, and Hind III. Copy number of this plasmid has been estimated to be about 30. A number of hybrid plasmids have been constructed between pCCl and pBR329 from Escherichia coli and transformed into corynebacteria. The thiostrepton resistance gene (tsr) from Streptomyces azureus has been inserted into them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454379
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  • 5
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    Isolation and physical characterization of plasmid pCCl from Corynebacterium callunae and construction of hybrid derivatives (1984)
    Springer
    Details
    Publication Date: 1984-06-01
    Print ISSN: 0175-7598
    Electronic ISSN: 1432-0614
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Springer
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  • 6
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    A Report on the Atoyac, Mexico, Earthquake of 13 April 2007 (Mw 5.9) (2007)
    Seismological Society of America
    Details
    Publication Date: 2007-11-01
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America
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