Publication Date:
1986-09-19
Description:
WIN 51711 and WIN 52084 are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses. They prevent the pH-mediated uncoating of the viral RNA. The compounds consist of a 3-methylisoxazole group that inserts itself into the hydrophobic interior of the VP1 beta-barrel, a connecting seven-membered aliphatic chain, and a 4-oxazolinylphenoxy group (OP) that covers the entrance to an ion channel in the floor of the "canyon." Viral disassembly may be inhibited by preventing the collapse of the VP1 hydrophobic pocket or by blocking the flow of ions into the virus interior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, T J -- Kremer, M J -- Luo, M -- Vriend, G -- Arnold, E -- Kamer, G -- Rossmann, M G -- McKinlay, M A -- Diana, G D -- Otto, M J -- New York, N.Y. -- Science. 1986 Sep 19;233(4770):1286-93.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3018924" target="_blank"〉PubMed〈/a〉
Keywords:
Antiviral Agents/metabolism/*pharmacology
;
Binding Sites
;
Chemical Phenomena
;
Chemistry
;
Humans
;
Isoxazoles/metabolism/pharmacology
;
Poliovirus/drug effects/metabolism
;
Rhinovirus/*drug effects/metabolism
;
X-Ray Diffraction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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