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5-fluorouracil, doxorubicin, and mitomycin-C in the treatment of adenocarcinoma and large cell carcinoma of the lung (1987)

Shaw, Michael T. ; Shaw, Melinda K.

Wiley

In: Cancer. 1987; 60(6): 1190-1193. Published 1987 Sep 15. doi: 10.1002/1097-0142(19870915)60:6〈1190::aid-cncr2820600606〉3.0.co;2-7.

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Publikationsdatum: 1987-09-15

Print ISSN: 0008-543X

Digitale ISSN: 1097-0142

Thema: Biologie , Medizin

Publiziert von Wiley im Namen von American Cancer Society.

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2

Digitale Medien

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA (2005)

Judge, Adam D ; Sood, Vandana ; Shaw, Janet R ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 457-462

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Short interfering RNAs (siRNAs) that mediate specific gene silencing through RNA interference (RNAi) are widely used to study gene function and are also being developed for therapeutic applications. Many nucleic acids, including double- (dsRNA) and single-stranded RNA (ssRNA), can stimulate innate ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1081

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3

Digitale Medien

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis (2005)

Camps, Montserrat ; Rückle, Thomas ; Ji, Hong ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 11 (2005), S. 936-943

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor biopharmaceutical profile of PI3K inhibitors have so ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1284

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4

Digitale Medien

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC (2006)

de Bakker, Paul I W ; McVean, Gil ; Sabeti, Pardis C ; [weitere]

[s.l.] : Nature Publishing Group

Nature genetics 38 (2006), S. 1166-1172

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The proteins encoded by the classical HLA class I and class II genes in the major histocompatibility complex (MHC) are highly polymorphic and are essential in self versus non-self immune recognition. HLA variation is a crucial determinant of transplant rejection and susceptibility to a large number ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng1885

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5

Digitale Medien

ALS: life and death in a bad neighborhood (2006)

Monk, Peter N ; Shaw, Pamela J

[s.l.] : Nature Publishing Group

Nature medicine 12 (2006), S. 885-887

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Our understanding of immunity in the central nervous system (CNS) lags well behind our understanding of it in the periphery. That lack of knowledge contributes to our poor understanding of many neurological diseases, which often have an immune component. For instance, activation of microglia, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0806-885

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6

Digitale Medien

Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability (2006)

Pittman, Alan M ; Willatt, Lionel ; Martin, Howard ; [weitere]

[s.l.] : Nature Publishing Group

Nature genetics 38 (2006), S. 1032-1037

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ISSN: 1546-1718

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Recently, the application of array-based comparative genomic hybridization (array CGH) has improved rates of detection of chromosomal imbalances in individuals with mental retardation and dysmorphic features. Here, we describe three individuals with learning disability and a heterozygous deletion ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/ng1858

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7

Digitale Medien

Broad HIV-1 neutralization mediated by CD4-binding site antibodies (2007)

Li, Yuxing ; Migueles, Stephen A ; Welcher, Brent ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 13 (2007), S. 1032-1034

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4–binding region of HIV-1 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1624

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8

Digitale Medien

The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3 (1987)

Selvaraj, Periasamy ; Plunkett, Marian L. ; Dustin, Michael ; [weitere]

[s.l.] : Nature Publishing Group

Nature 326 (1987), S. 400-403

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] We established an assay of purified CD2 binding to human lymphoid cells. CD2 was solubilized with the detergent Triton X-100 and purified to near homogeneity from the human T lymphoblast line SKW3 by affinity chromatography as described12'13 and labelled with 125I (Fig. la inset). CD2 was shown to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/326400a0

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9

Digitale Medien

Summing up The Simpsons (2007)

Shaw, J. Ewart H.

[s.l.] : Nature Publishing Group

Nature 448 (2007), S. 865-865

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Sir ...In your amusing News Feature interview with Harvard mathematics graduate Al Jean, head writer of The Simpsons ('Mmm... Pi' Nature 448, 404; 2007), Jean mentions, as an example of a staggeringly obscure mathematical reference, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/448865c

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10

Digitale Medien

Veterinary epidemiology Vaccination strategies for foot-and-mouth disease (reply) (2007)

Savill, Nicholas J. ; Shaw, Darren J. ; Deardon, Rob ; [weitere]

[s.l.] : Nature Publishing Group

Nature 445.2007, 7128, E12-, (2 S.)

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] Kitching express concerns about our mathematical models of reactive vaccination strategies for the control of foot-and-mouth disease epidemics. However, in our view, these concerns are misplaced. Kitching et al. note that simulated epidemic sizes can be highly variable, but they ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nature05605

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