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  • Springer  (65)
  • American Society of Hematology  (31)
  • 2005-2009  (52)
  • 1985-1989  (42)
  • 1950-1954  (2)
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  • 1
    Publikationsdatum: 1988-09-01
    Beschreibung: Erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) are abnormally sensitive to complement. Two membrane proteins, the C8 binding protein (C8bp) and the decay accelerating factor (DAF), which are expressed on normal cells, function to restrict lysis by homologous complement, and both of these proteins are absent from PNH erythrocytes. DAF is anchored to the plasma membrane on normal cells by a phosphatidylinositol linkage. The investigators found that a purified phosphatidylinositol-specific phospholipase C cleaved C8bp from the surface of normal lymphocytes and monocytes. This finding indicates that the abnormal complement sensitivity of PNH erythrocytes arises from a common defect, the inability to attach the phosphatidylinositol- containing anchor that is necessary for the membrane expression of both membrane complement regulatory proteins, the C8bp, and DAF.
    Print ISSN: 0006-4971
    Digitale ISSN: 1528-0020
    Thema: Biologie , Medizin
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 1988-09-01
    Beschreibung: Erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) are abnormally sensitive to complement. Two membrane proteins, the C8 binding protein (C8bp) and the decay accelerating factor (DAF), which are expressed on normal cells, function to restrict lysis by homologous complement, and both of these proteins are absent from PNH erythrocytes. DAF is anchored to the plasma membrane on normal cells by a phosphatidylinositol linkage. The investigators found that a purified phosphatidylinositol-specific phospholipase C cleaved C8bp from the surface of normal lymphocytes and monocytes. This finding indicates that the abnormal complement sensitivity of PNH erythrocytes arises from a common defect, the inability to attach the phosphatidylinositol- containing anchor that is necessary for the membrane expression of both membrane complement regulatory proteins, the C8bp, and DAF.
    Print ISSN: 0006-4971
    Digitale ISSN: 1528-0020
    Thema: Biologie , Medizin
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Journal of insect behavior 2 (1989), S. 397-411 
    ISSN: 1572-8889
    Schlagwort(e): social competition ; solitary gynes ; Halictidae ; size ; pheromones
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Solitary gynes of two species of social bees, Lasioglossum (Evylaeus) malachurumand L. (E.) pauxillum(Hymenoptera: Halictidae), were observed in the field and in the laboratory during the solitary (spring) phase of their life cycles. Fighting over nests among gynes of the former species is common when nests are being provisioned and can result in serious injury or even death to one or both interactants. The payoff is occasional acquisition of a nest. In contrast, fighting was never observed in the field among gynes of L. pauxillum.Several factors determine the outcome of such fights in L. malachuram,these include relative sizes of the two opponents as well as nest ownership. Dyadic interactions in the laboratory reveal that size influences the behavioral strategies of the gynes of both species, with the larger of two individuals in a dyadic interaction being on average more aggressive. Furthermore, in a second experimental series with L. malachurum,application to the smaller gyne of synthetically derived macrocyclic lactones found in the species' Dufour's gland pheromone mixture significantly decreased the aggressive tendencies of the larger such that its behavior was no longer significantly different from that for the smaller gyne. Therefore, among gynes, aggressive pheromonal signaling, coupled with other possible signal modalities, is probably an integral part in the communication system.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Applied physics 42 (1987), S. 173-179 
    ISSN: 1432-0649
    Schlagwort(e): 82.50 ; 33.50 ; 06.50
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract The rotational distribution of OH(X 2Π,v″=0) radicals was investigated by resonant laser-induced fluorescence (LIF) after photolysis of H2O2 at 193 nm. A microcomputer equipped LIF arrangement allowed special shot-by-shot normalization of the fluorescence signal for noise reduction. Using a least-squares procedure we were able to account for all measured line intensities including overlapping lines (blends) and obtain a complete rotational state distribution of the OH(X 2Π,v″=0) state. The rotational excitation shows a Gaussian-like distribution with a maximum atK″=12 and with 16% of the total available energy (17,400 cm−1) appearing in rotation. Only 1% of the available energy is converted into vibration, leaving over 83% for translational excitation. The measured rotational distribution appears to fit a semiclassical theory.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    ISSN: 1432-0630
    Schlagwort(e): 73.20.Dx ; 78.55.Cr ; 78.47.+p
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract We present a phenomenological theoretical model to treat the trapping of carriers into quantum wells of semiconductor laser structures. We consider explicitely the transport within the barrier layers by solving the continuity equation with the appropriate boundary conditions taking into account surface recombination, radiative and nonradiative recombination in the barrier layers and trapping of carriers into the quantum wells. The experimental findings for the trapping dynamics in GaAs/AlGaAs quantum well structures can be consistently interpreted by the model calculations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Applied physics 49 (1989), S. 599-618 
    ISSN: 1432-0630
    Schlagwort(e): 75.70 ; 78.20L
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Maschinenbau , Physik
    Notizen: Abstract We present an experimental investigation of magneto-optic (MO) thin film materials of interest in optical storage. XPS valence band spectra of ultrahigh vacuum deposited rare earth — Fe50Co50 alloys are correlated to magneto-optic and reflectivity spectra measured ex-situ in the photon energy range 0.5 ≦E ph ≦ 5.5 eV. It is found that 4f n →4f n−15d 1 optical transitions contribute to room temperature Kerr spectra in Pr-FeCo and Nd-FeCo, but only in the UV spectral region (λ≦300 nm). Eu is found to enter Eu-FeCo intermetallic alloys with a 4f 7 ground state at −2 eV binding energy. However, no substantial contribution to the Kerr effect from excitations of this electronic state has been observed n either at room temperaturen or at 100 K. We present a general argument that 4f excitations of RE ions in typical intermetallic alloys can never be expected to contribute more than some tenths of a degree toθ k in contrast to the well known huge rotations in RE-chalcogenides. For Yb-FeCo we have observed in XPS a mixed valence behavior of Yb showing a discontinuous transition from divalent Yb2+ in the pure metal to mixed valent Yb2.55+ in amorphous Yb-FeCo films. Nof→d contributions to the room temperature MO spectra have been detected. Strong optical enhancement effects are presented for metallic bilayer and multilayer structures of the type MO-layer/reflector. The total thickness of an optimized structure corresponds to about two times the penetration depth of light. Enhancement occurs predominantly at photon energies below the plasma frequency of the reflector material and is caused by low values of the optical constantsn andk of the reflector. In storage materials like Tb-FeCo the read-out performance can be improved by about a factor of 2 with a bilayer of 30 nm Tb-FeCo on Cu. Quantitative modelling of the optical and magneto-optic properties of these films is discussed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    The annals of regional science 21 (1987), S. 34-43 
    ISSN: 1432-0592
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie , Wirtschaftswissenschaften
    Notizen: Abstract The problem investigated in this paper is that of forecasting employment levels (both raw and seasonally adjusted) in small regions, regions typically lacking data sufficient for the construction of simultaneous equation econometric models. The method employed is transfer function analysis using readily available national variables as drivers. The results suggest that the transfer function approach is capable of providing accurate forecasts of employment levels in small regions, forecast accuracy being measured in terms of mean absolute percentage errors and root mean squared errors. We conclude on the basis of this demonstrated accuracy that this approach is a viable method for forecasting selected variables in a small region context.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Environmental management 12 (1988), S. 695-701 
    ISSN: 1432-1009
    Schlagwort(e): Wetlands ; Wildlife ; Habitat ; Cumulative impacts ; Losses ; Perturbations ; Waterbirds
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Energietechnik
    Notizen: Abstract Wetlands are attractive to vertebrates because of their abundant nutrient resources and habitat diversity. Because they are conspicuous, vertebrates commonly are used as indicators of changes in wetlands produced by environmental impacts. Such impacts take place at the landscape level where extensive areas are lost; at the wetland complex level where some (usually small) units of a closely spaced group of wetlands are drained or modified; or at the level of the individual wetland through modification or fragmentation that impacts its habitat value. Vertebrates utilize habitats differently according to age, sex, geographic location, and season, and habitat evaluations based on isolated observations can be biased. Current wetland evaluation systems incorporate wildlife habitat as a major feature, and the habitat evaluation procedure focuses only on habitat. Several approaches for estimating bird habitat losses are derived from population curves based on natural and experimentally induced population fluctuations. Additional research needs and experimental approaches are identified for addressing cumulative impacts on wildlife habitat values.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Human genetics 〈Berlin〉 77 (1987), S. 118-121 
    ISSN: 1432-1203
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The rare fragile site at 17p12 can be induced in lymphocyte cultures with the AT-specific DNA-ligands distamycin A, DAPI, Hoechst 33258 and berenil. The optimum culture conditions for the experimental induction of fra(17)(p12) were studied. There are indications that fra(17)(p12) is a latereplicating chromosome region in which AT-rich DNA is located. The fragile site also occurs spontaneously in cell cultures of most fra(17)(p12) carriers. A population screening of 250 unselected individuals showed that the frequency of carriers heterozygous for fra(17)(p12) is 2%. The results are compatible with a population being in Hardy-Weinberg equilibrium with respect to fra(17)(p12) and its non-fragile allelomorph. Neither the heterozygous nor the homozygous condition of fra(17)(p12) have any deleterious effects.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Naturwissenschaften 40 (1953), S. 17-18 
    ISSN: 1432-1904
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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