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  • Articles  (136)
  • 2005-2009  (89)
  • 1985-1989  (37)
  • 1975-1979  (7)
  • 1960-1964  (1)
  • 1870-1879  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    A Dutch test with the NewProd-Model (1988)
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 18 (1988), S. 0 
    Details
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: The paper contains a report of a test of Cooper's NewProd model for predicting success and failure of product development projects. Based on Canadian data, the model has been shown to make predictions which are 84% correct. Having reservations on the reliability and validity of the model on theoretical grounds, we set out to test it using data collected in the Netherlands.Following Cooper's methodology, we selected 19 projects, which had already been marketed and of which 9 were clearcut successes and 10 clearcut failures. We also studied 9 additional projects, which had not yet been commercialised, as the basis for a future a priori test. The projects were given a product score according to Cooper's criteria, and predictions compared with the actual experience. Eightyfour percent were correctly classified, as in Cooper's work. From a practical point of view however the variance was too large to allow the predictions from NewProd to be used with confidence to predict outcomes unless they are clearcut.We believe that the drawback of the methodology is that the product score is a simple combination of the various factors involved. No allowance is made for the possibility that one factor alone might be responsible for failure. We have therefore introduced the concept of a threshold value for each factor. A project for which any factor falls below this value will be deemed a failure. Based on a very limited sample of 19 cases an improvement of reliability was made to 95% of 18 out of 19 products correctly classified. The NewProd concept so modified is being applied to the sample of 9 as yet uncompleted projects, and its predictions will eventually be compared with actual outcomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-9310.1988.tb00607.x
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  • 2
    Electronic Resource
    Electronic Resource
    PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability (2005)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 55 (2005), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In the yeast Saccharomyces cerevisiae, PKA and Sch9 exert similar physiological roles in response to nutrient availability. However, their functional redundancy complicates to distinguish properly the target genes for both kinases. In this article, we analysed different phenotypic read-outs. The data unequivocally showed that both kinases act through separate signalling cascades. In addition, genome-wide expression analysis under conditions and with strains in which either PKA and/or Sch9 signalling was specifically affected, demonstrated that both kinases synergistically or oppositely regulate given gene targets. Unlike PKA, which negatively regulates stress-responsive element (STRE)- and post-diauxic shift (PDS)-driven gene expression, Sch9 appears to exert additional positive control on the Rim15-effector Gis1 to regulate PDS-driven gene expression. The data presented are consistent with a cyclic AMP (cAMP)-gating phenomenon recognized in higher eukaryotes consisting of a main gatekeeper, the protein kinase PKA, switching on or off the activities and signals transmitted through primary pathways such as, in case of yeast, the Sch9-controlled signalling route. This mechanism allows fine-tuning various nutritional responses in yeast cells, allowing them to adapt metabolism and growth appropriately.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.2004.04429.x
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  • 3
    Electronic Resource
    Electronic Resource
    Informal contacts and performance in innovation teams (2005)
    Bingley : Emerald
    International journal of manpower 26 (2005), S. 513-528 
    Details
    ISSN: 0143-7720
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Purpose - The paper addresses the effect friendly and friendship relationships among members of innovation teams on the performance of the teams. Design/methodology/approach - The members of innovation teams may develop friendly and friendship relationships over time. In our study, we focus on the effect of the frequency of such non-work relationships on team performance. For this research, we collected full network data on non-work relationships in a sample of 44 innovation teams and investigate how these "friendly and friendship networks" affect the performance of innovation teams. Findings - As result turns out that the frequency of friendly ties has positive as well as negative consequences on team performance, whereas the frequency of friendship ties positively relates to the performance. Research limitations/implications - The results indicate the importance of informal relations for the performance of innovation teams. Further, it is shown that friendly and friendship relations have different theoretical and practical implications. Future research can overcome the limitations of the presented research by concentrating on larger sample sizes and longitudinal research designs. Practical implications - Building on the results of the study managers can better orchestra innovation teams focussing not only on formal but also on informal contacts. The main practical implication is to strive for friendship contacts and to avoid too strong friendly contacts. Originality/value - The study adds knowledge to the research on informal relationships and performance two-fold. First, the findings testify that friendly and friendship contacts are different and not part of the same dimension, and there is strong evidence for the importance of informal contacts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/01437720510625430
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  • 4
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie des Schwefels. CXVII. Kristall- und Molekülstruktur von 7,8,9,16,17,18-Hexathiadispirol[5.3.5.3]octadecan (1979)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 35 (1979), S. 1853-1857 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0567740879007901
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  • 5
    Electronic Resource
    Electronic Resource
    Structure of 3-(2-hydroxy-4-methylphenyl)-3-phenylphthalide (1988)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 44 (1988), S. 537-540 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270187009648
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  • 6
    Electronic Resource
    Electronic Resource
    Comparative study of the crystal structures of isotypic MX2.H2O, M = Sr, Ba, and X = Cl, Br, I. Bifurcated H bonds in solid hydrates (1987)
    Copenhagen : International Union of Crystallography (IUCr)
    Acta crystallographica 43 (1987), S. 71-75 
    Details
    ISSN: 1600-5740
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108768187098288
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of petrochemical sludge concentrations on microbial communities during soil bioremediation (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology ecology 53 (2005), S. 0 
    Details
    ISSN: 1574-6941
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Qualitative and quantitative changes of microbial communities in soil microcosms during bioremediation were determined throughout one year. The soil was contaminated with 0%, 2.5%, 5%, 10% (wt/wt) of petrochemical sludge containing polynuclear aromatic hydrocarbons. We analyzed the hydrocarbon concentration in the microcosms, the number of cultivable bacteria using CFU and most probable number assays, the community structure using denaturing gradient gel electrophoresis, and the metabolic activity of soil using dehydrogenase activity and substrate-induced respiration assays. After one year of treatment, the chemical analysis suggested that the hydrocarbon elimination process was over. The biological analysis, however, showed that the contaminated microcosms suffered under long-term disturbance. The number of heterotrophic bacteria that increased after sludge addition (up to 108–109 cells ml−1) has not returned to the level of the control soil (2–6 × 107 cells ml−1). The community structure in the contaminated soils differed considerably from that in the control. The substrate-induced respiration of the contaminated soils was significantly lower (10-fold) and the dehydrogenase activity was significantly higher (20–40-fold) compared to the control. Changes in the community structure of soils depended on the amount of added sludge. The species, which were predominant in the sludge community, could not be detected in the contaminated soils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsec.2005.01.014
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement ofJ/ψ and ψ′ real photoproduction on lithium-6 at a mean energy of 90 GeV (1987)
    Springer
    The European physical journal 33 (1987), S. 505-512 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Inelastic and elasticJ/ψ (3097) photoproduction on Li6 are measured at a mean γ energy of 90 GeV in an open spectrometer. TheJ/ψ are identified by their decays intoμ + μ − ore + e −. A signal of ψ′(3685) intoμ + μ − andJ/ψπ + π − is also seen. The inelastic cross-section withZ=E ψ/Eγ〈0.9 is compared in shape and magnitude with the colour singlet model of photon-gluon fusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01548261
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  • 9
    Electronic Resource
    Electronic Resource
    Het eisenacher (katheder-socialistisch) congres (1873)
    Springer
    De economist 22 (1873), S. 459-487 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02183330
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  • 10
    Electronic Resource
    Electronic Resource
    Het Eisenacher (Katheder-Socialistisch) Congres (1873)
    Springer
    De economist 22 (1873), S. 321-338 
    Details
    ISSN: 1572-9982
    Source: Springer Online Journal Archives 1860-2000
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02183323
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