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  • Animals  (10)
  • Humans  (10)
  • Earthquake  (4)
  • ASTROPHYSICS  (3)
  • 2005-2009  (15)
  • 1990-1994  (5)
  • 1
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    Generation of transgenic non-human primates with germline transmission (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-05-30
    Description: The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human primate animal model in biomedical research. It has a relatively high reproduction rate for a primate, making it potentially suitable for transgenic modification. Although several attempts have been made to produce non-human transgenic primates, transgene expression in the somatic tissues of live infants has not been demonstrated by objective analyses such as polymerase chain reaction with reverse transcription or western blots. Here we show that the injection of a self-inactivating lentiviral vector in sucrose solution into marmoset embryos results in transgenic common marmosets that expressed the transgene in several organs. Notably, we achieved germline transmission of the transgene, and the transgenic offspring developed normally. The successful creation of transgenic marmosets provides a new animal model for human disease that has the great advantage of a close genetic relationship with humans. This model will be valuable to many fields of biomedical research.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sasaki, Erika -- Suemizu, Hiroshi -- Shimada, Akiko -- Hanazawa, Kisaburo -- Oiwa, Ryo -- Kamioka, Michiko -- Tomioka, Ikuo -- Sotomaru, Yusuke -- Hirakawa, Reiko -- Eto, Tomoo -- Shiozawa, Seiji -- Maeda, Takuji -- Ito, Mamoru -- Ito, Ryoji -- Kito, Chika -- Yagihashi, Chie -- Kawai, Kenji -- Miyoshi, Hiroyuki -- Tanioka, Yoshikuni -- Tamaoki, Norikazu -- Habu, Sonoko -- Okano, Hideyuki -- Nomura, Tatsuji -- England -- Nature. 2009 May 28;459(7246):523-7. doi: 10.1038/nature08090.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Central Institute for Experimental Animals, 1430 Nogawa, Miyamae-ku, Kawasaki, Kanagawa 216-0001, Japan. esasaki@ciea.or.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19478777" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Genetically Modified/*genetics ; Animals, Newborn ; Callithrix/embryology/*genetics ; *Disease Models, Animal ; Gene Expression Profiling ; Germ Cells/*metabolism ; Green Fluorescent Proteins/genetics ; Heredity/*genetics ; Humans ; Transcription, Genetic ; Transgenes/*genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    alpha-Klotho as a regulator of calcium homeostasis (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-06-16
    Description: alpha-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of alpha-Klotho (alpha-Kl) and Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K+-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an alpha-Kl- and Na+,K+-ATPase-dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of alpha-Kl in the regulation of calcium metabolism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Imura, Akihiro -- Tsuji, Yoshihito -- Murata, Miyahiko -- Maeda, Ryota -- Kubota, Koji -- Iwano, Akiko -- Obuse, Chikashi -- Togashi, Kazuya -- Tominaga, Makoto -- Kita, Naoko -- Tomiyama, Ken-ichi -- Iijima, Junko -- Nabeshima, Yoko -- Fujioka, Makio -- Asato, Ryo -- Tanaka, Shinzo -- Kojima, Ken -- Ito, Juichi -- Nozaki, Kazuhiko -- Hashimoto, Nobuo -- Ito, Tetsufumi -- Nishio, Takeshi -- Uchiyama, Takashi -- Fujimori, Toshihiko -- Nabeshima, Yo-ichi -- New York, N.Y. -- Science. 2007 Jun 15;316(5831):1615-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569864" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/cerebrospinal fluid/*metabolism ; Cell Membrane/enzymology/metabolism ; Choroid Plexus/metabolism ; Cytoplasm/enzymology/metabolism ; Endoplasmic Reticulum/metabolism ; Endosomes/metabolism ; Enzyme Inhibitors/pharmacology ; Feedback, Physiological ; Glucuronidase/genetics/metabolism/*physiology ; Golgi Apparatus/metabolism ; HeLa Cells ; *Homeostasis ; Humans ; Ion Transport ; Kidney/enzymology/metabolism ; Mice ; Ouabain/pharmacology ; Parathyroid Glands/enzymology/metabolism ; Parathyroid Hormone/secretion ; Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Heat signature on the Chelungpu fault associated with the 1999 Chi-Chi, Taiwan earthquake (2006)
    In:  Geophys. Res. Lett., Amsterdam, Elsevier Scientific Publishing Company, vol. 33, no. 14, pp. 879-897, pp. L14306, (ISSN: 1340-4202)
    Details
    Publication Date: 2006
    Keywords: Geothermics ; Friction ; Fault zone ; China ; Earthquake ; GRL ; 5134 ; Physical ; Properties ; of ; Rocks: ; Thermal ; properties ; 7209 ; Seismology: ; Earthquake ; dynamics ; (1242) ; 8130 ; Tectonophysics: ; Heat ; generation ; and ; transport ; 8163 ; Rheology ; and ; friction ; of ; fault ; zones ; (8034)
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    BIBLIOGRAPHY SEISMOLOGY
  • 4
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    Very low frequency earthquakes within accretionary prisms are very low stress-drop earthquakes (2006)
    In:  Geophys. Res. Lett., Amsterdam, Schweizerbart'sche Verlagsbuchhandlung, vol. 33, no. 9, pp. 1-4, pp. L09302, (ISSN 0016-8548, ISBN 3-510-50045-8)
    Details
    Publication Date: 2006
    Keywords: red ; slow ; silent ; Earthquake ; Subduction zone ; Stress drop ; Seismology ; GRL ; 7203 ; Seismology: ; Body ; waves ; 7215 ; Earthquake ; source ; observations ; 7240 ; Subduction ; zones ; 8118 ; Tectonophysics: ; Dynamics ; and ; mechanics ; of ; faulting ; 8170 ; Subduction ; zone ; processes
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    BIBLIOGRAPHY SEISMOLOGY
  • 5
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    Did expanded porous patches guide rupture propagation in 2003 Tokachi-oki earthquake? (2005)
    In:  Geophys. Res. Lett., Taipei, EGS, vol. 32, no. 20, pp. 105-121, pp. L20310, (ISSN: 1340-4202)
    Details
    Publication Date: 2005
    Keywords: Deep seismic sounding (espec. cont. crust) ; Reflection seismics ; 4D ; Aftershocks ; Earthquake asperities ; Fracture ; Earthquake ; Seismology ; Rock mechanics ; Physical properties of rocks ; GRL ; 3225 ; Mathematical ; Geophysics: ; Numerical ; approximations ; and ; analysis ; (4260) ; 3653 ; Mineralogy ; and ; Petrology: ; Fluid ; flow ; 7230 ; Seismology: ; Seismicity ; and ; tectonics ; (1207, ; 1217, ; 1240, ; 1242) ; 7240 ; Subduction ; zones ; (1207, ; 1219, ; 1240)
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  • 6
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    Source fault structure of the 2003 Bam earthquake, southeastern Iran, inferred from the aftershock distribution and its relation to the heavily damaged area: Existence of the Arg-e-Bam fault proposed (2005)
    In:  Geophys. Res. Lett., Colorado Springs, US Air Force Academy, vol. 32, no. 9, pp. 389-398, pp. L09308, (ISSN: 1340-4202)
    Details
    Publication Date: 2005
    Keywords: Earthquake ; Aftershocks ; Source parameters ; Fault zone ; GRL
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    BIBLIOGRAPHY SEISMOLOGY
  • 7
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    PML targeting eradicates quiescent leukaemia-initiating cells (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-13
    Description: The existence of a small population of 'cancer-initiating cells' responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia-initiating cells, particularly those that are in a quiescent state, are thought to be resistant to chemotherapy and targeted therapies, resulting in disease relapse. Chronic myeloid leukaemia is a paradigmatic haematopoietic stem cell disease in which the leukaemia-initiating-cell pool is not eradicated by current therapy, leading to disease relapse on drug discontinuation. Here we define the critical role of the promyelocytic leukaemia protein (PML) tumour suppressor in haematopoietic stem cell maintenance, and present a new therapeutic approach for targeting quiescent leukaemia-initiating cells and possibly cancer-initiating cells by pharmacological inhibition of PML.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712082/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712082/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ito, Keisuke -- Bernardi, Rosa -- Morotti, Alessandro -- Matsuoka, Sahoko -- Saglio, Giuseppe -- Ikeda, Yasuo -- Rosenblatt, Jacalyn -- Avigan, David E -- Teruya-Feldstein, Julie -- Pandolfi, Pier Paolo -- K99 CA139009/CA/NCI NIH HHS/ -- R00 CA139009/CA/NCI NIH HHS/ -- R37 CA071692/CA/NCI NIH HHS/ -- R37 CA071692-12/CA/NCI NIH HHS/ -- England -- Nature. 2008 Jun 19;453(7198):1072-8. doi: 10.1038/nature07016. Epub 2008 May 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18469801" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Arsenicals/pharmacology/therapeutic use ; Cell Line ; Coculture Techniques ; Female ; Gene Expression Regulation, Neoplastic ; Hematopoietic Stem Cells/pathology ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism/*pathology ; Male ; Mice ; Mice, Inbred C57BL ; Neoplastic Stem Cells/metabolism/*pathology ; Nuclear Proteins/antagonists & inhibitors/deficiency/genetics/*metabolism ; Oxides/pharmacology/therapeutic use ; Recurrence ; Regeneration ; Transcription Factors/antagonists & inhibitors/deficiency/genetics/*metabolism ; Tumor Suppressor Proteins/antagonists & ; inhibitors/deficiency/genetics/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 8
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    IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-06-06
    Description: Insulin-like growth-factor-binding proteins (IGFBPs) bind to and modulate the actions of insulin-like growth factors (IGFs). Although some of the actions of IGFBPs have been reported to be independent of IGFs, the precise mechanisms of IGF-independent actions of IGFBPs are largely unknown. Here we report a previously unknown function for IGFBP-4 as a cardiogenic growth factor. IGFBP-4 enhanced cardiomyocyte differentiation in vitro, and knockdown of Igfbp4 attenuated cardiomyogenesis both in vitro and in vivo. The cardiogenic effect of IGFBP-4 was independent of its IGF-binding activity but was mediated by the inhibitory effect on canonical Wnt signalling. IGFBP-4 physically interacted with a Wnt receptor, Frizzled 8 (Frz8), and a Wnt co-receptor, low-density lipoprotein receptor-related protein 6 (LRP6), and inhibited the binding of Wnt3A to Frz8 and LRP6. Although IGF-independent, the cardiogenic effect of IGFBP-4 was attenuated by IGFs through IGFBP-4 sequestration. IGFBP-4 is therefore an inhibitor of the canonical Wnt signalling required for cardiogenesis and provides a molecular link between IGF signalling and Wnt signalling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhu, Weidong -- Shiojima, Ichiro -- Ito, Yuzuru -- Li, Zhi -- Ikeda, Hiroyuki -- Yoshida, Masashi -- Naito, Atsuhiko T -- Nishi, Jun-ichiro -- Ueno, Hiroo -- Umezawa, Akihiro -- Minamino, Tohru -- Nagai, Toshio -- Kikuchi, Akira -- Asashima, Makoto -- Komuro, Issei -- England -- Nature. 2008 Jul 17;454(7202):345-9. doi: 10.1038/nature07027. Epub 2008 Jun 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18528331" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Differentiation ; Cell Line, Tumor ; Embryo, Nonmammalian/embryology ; Heart/*embryology ; Insulin-Like Growth Factor Binding Protein 4/*metabolism ; LDL-Receptor Related Proteins/metabolism ; Low Density Lipoprotein Receptor-Related Protein-6 ; Mice ; Myocytes, Cardiac/*cytology/*metabolism ; Receptors, G-Protein-Coupled/metabolism ; *Signal Transduction ; Somatomedins/metabolism ; Wnt Proteins/antagonists & inhibitors/metabolism ; Wnt3 Protein ; Wnt3A Protein ; Xenopus Proteins ; Xenopus laevis ; beta Catenin/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
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    Big data: the next Google. Interview by Duncan Graham-Rowe (2008)
    Nature Publishing Group (NPG)
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    Publication Date: 2008-09-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buxton, Bill -- Hayward, Vincent -- Pearson, Ian -- Karkkainen, Leo -- Greiner, Helen -- Dyson, Esther -- Ito, Joi -- Chung, Anshe -- Kelly, Kevin -- Schillace, Sam -- England -- Nature. 2008 Sep 4;455(7209):8-9. doi: 10.1038/455008a.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18769400" target="_blank"〉PubMed〈/a〉
    Keywords: Computer Graphics/trends ; Electronics/trends ; Genetic Predisposition to Disease ; Humans ; Internet/*trends ; Records as Topic ; Robotics/trends ; Touch ; User-Computer Interface
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 10
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    Distinct sensory representations of wind and near-field sound in the Drosophila brain (2009)
    Nature Publishing Group (NPG)
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    Publication Date: 2009-03-13
    Description: Behavioural responses to wind are thought to have a critical role in controlling the dispersal and population genetics of wild Drosophila species, as well as their navigation in flight, but their underlying neurobiological basis is unknown. We show that Drosophila melanogaster, like wild-caught Drosophila strains, exhibits robust wind-induced suppression of locomotion in response to air currents delivered at speeds normally encountered in nature. Here we identify wind-sensitive neurons in Johnston's organ, an antennal mechanosensory structure previously implicated in near-field sound detection (reviewed in refs 5 and 6). Using enhancer trap lines targeted to different subsets of Johnston's organ neurons, and a genetically encoded calcium indicator, we show that wind and near-field sound (courtship song) activate distinct populations of Johnston's organ neurons, which project to different regions of the antennal and mechanosensory motor centre in the central brain. Selective genetic ablation of wind-sensitive Johnston's organ neurons in the antenna abolishes wind-induced suppression of locomotion behaviour, without impairing hearing. Moreover, different neuronal subsets within the wind-sensitive population respond to different directions of arista deflection caused by air flow and project to different regions of the antennal and mechanosensory motor centre, providing a rudimentary map of wind direction in the brain. Importantly, sound- and wind-sensitive Johnston's organ neurons exhibit different intrinsic response properties: the former are phasically activated by small, bi-directional, displacements of the aristae, whereas the latter are tonically activated by unidirectional, static deflections of larger magnitude. These different intrinsic properties are well suited to the detection of oscillatory pulses of near-field sound and laminar air flow, respectively. These data identify wind-sensitive neurons in Johnston's organ, a structure that has been primarily associated with hearing, and reveal how the brain can distinguish different types of air particle movements using a common sensory organ.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755041/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755041/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yorozu, Suzuko -- Wong, Allan -- Fischer, Brian J -- Dankert, Heiko -- Kernan, Maurice J -- Kamikouchi, Azusa -- Ito, Kei -- Anderson, David J -- R01 DC002780/DC/NIDCD NIH HHS/ -- T32 GM007737/GM/NIGMS NIH HHS/ -- T32 GM007737-30/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2009 Mar 12;458(7235):201-5. doi: 10.1038/nature07843.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biology 216-76, California Institute of Technology, Pasadena, California 91125, USA. yorozu@caltech.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19279637" target="_blank"〉PubMed〈/a〉
    Keywords: *Air Movements ; Animals ; Auditory Perception/*physiology ; Behavior, Animal/physiology ; Drosophila melanogaster/*physiology ; Electrophysiological Phenomena/physiology ; Mechanoreceptors/physiology ; Sensory Receptor Cells/*physiology
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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