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  • 2005-2009  (57)
  • 1990-1994  (32)
  • 1965-1969  (4)
  • 1
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    A human-specific gene in microglia (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2005-09-10
    Beschreibung: Recent studies have shown multiple differences between humans and apes in sialic acid (Sia) biology, including Siglecs (Sia-recognizing-Ig-superfamily lectins). Comparisons with the chimpanzee genome indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene. Conversion involved 5 cent untranslated sequences and the Sia-recognition domain. This human protein shows reduced binding relative to the ancestral form but recognizes oligosialic acids, which are enriched in the brain. SIGLEC11 is expressed in human but not in chimpanzee brain microglia. Further studies will determine if this event was related to the evolution of Homo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayakawa, Toshiyuki -- Angata, Takashi -- Lewis, Amanda L -- Mikkelsen, Tarjei S -- Varki, Nissi M -- Varki, Ajit -- R01GM32373/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Sep 9;309(5741):1693.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16151003" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Biological Evolution ; Brain/*metabolism ; Exons ; *Gene Conversion ; Humans ; Lectins/*genetics/metabolism ; Membrane Proteins/*genetics/metabolism ; Microglia/*metabolism ; Pan troglodytes/genetics/metabolism ; Phylogeny ; Pongo pygmaeus/genetics/metabolism ; Pseudogenes ; Regulatory Sequences, Nucleic Acid ; Sialic Acids/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
    Digitale Medien
    Digitale Medien
    Comparison of As species (As4 and As2) in molecular beam epitaxial growth of AlxGa1−xAs (x=0.2–0.7) on (100) GaAs (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 2415-2417 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Systematic studies have been made for the first time on the basic properties of AlxGa1−xAs (x=0.2–0.7) grown by molecular beam epitaxy in the wide growth temperature range of 540–780 °C with As4 and As2. The forbidden growth temperature region (FTR), where the specular smooth surface cannot be obtained, has been found to depend strongly upon both the As species and the AlAs mole fraction x. FTR does not change with x in the case of As4; however, in the case of As2, FTR does not exist for x=0.2 and it increases with x from 0.3–0.7. Photoluminescence of n-Al0.3Ga0.7As (Si=1×1018 cm−3) grown with As2 shows lower intensity and higher sensitivity to growth temperature than those of samples grown with As4. Deep level transient spectroscopy has been measured on n-Al0.7Ga0.3As (Si=2×1016 cm−3). New electron traps are found in layers grown with As2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.106033
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Molecular beam epitaxial growth of AlxGa1−xAs (x=0.2–0.7) on (111)B-GaAs using As4 and As2 (1991)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 59 (1991), S. 2287-2289 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Basic properties of AlxGa1−xAs (x=0.2–0.7), grown by molecular beam epitaxy on 0.5°-tilted (111)B-GaAs, are studied. We have employed the wide substrate temperature, Ts, range of 540–740 °C and different As species; As4 and As2. The surface morphology has been found to depend strongly upon the As species; a specular surface morphology cannot be obtained when using As2 whereas a specular smooth surface can be obtained at high temperatures when using As4. Photoluminescence intensity of n-Al0.3Ga0.7As (Si=1×1018 cm−3) grown at low Ts (〈620–630 °C) does not depend upon the As species and is considered to be determined by defects, such as microtwins and stacking faults, which have been observed by transmission electron microscopy. At high Ts ((approximately-greater-than)650 °C) photoluminescence intensity is lower for the case of As2 than As4 and this could be due to point defects, such as As interstitials and/or antisite As (AsGa). Deep level transient spectroscopy has been measured on n-Al0.7Ga0.3As grown on (100)- and (111)B-substrates with As4.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.106045
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  • 4
    Digitale Medien
    Digitale Medien
    High power AlGaAs quantum well laser diodes prepared by molecular beam epitaxy (1993)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 63 (1993), S. 1718-1720 
    Details
    ISSN: 1077-3118
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Stable and reliable AlGaAs high power single quantum well lasers prepared by molecular beam epitaxy have been realized. We have prepared both 50-μm devices operating in multiple modes and ridge-waveguide single transverse-mode devices. Good reliability has been confirmed under the operating condition of 500 mW at 50 °C for the former type of devices and under the condition of 50 mW at 50 °C for the latter type of devices over 1000 h. These results indicate that molecular beam epitaxy is capable of making reliable high power laser diodes.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.110693
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  • 5
    Digitale Medien
    Digitale Medien
    A One-Step Sandwich Enzyme Immunoassay for Human Matrix Metalloproteinase 9 Using Monoclonal Antibodies (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 732 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb24752.x
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  • 6
    Digitale Medien
    Digitale Medien
    Interaction between Progelatinase A and TIMP-2 (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 732 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb24762.x
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  • 7
    Digitale Medien
    Digitale Medien
    In0.2Ga0.8As single strained quantum well lasers with GaAs/AlGaAs short-period superlattice barrier layers grown by molecular beam epitaxy (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 74 (1993), S. 5285-5287 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: In0.2Ga0.8As single strained quantum well lasers with GaAs/Al0.45Ga0.55As short-period superlattice barrier (SPSB)layers have been successfully prepared using molecular beam epitaxy although a part of SPSB has been grown in the forbidden temperature region for AlGaAs, where the specular smooth bulk AlGaAs cannot be grown. The averaged AlAs mole fraction of the present SPSB is 0.25, which gives the heterobarrier height larger than that of the conventional GaAs barrier layers. The threshold temperature sensitivity factor T0 of the laser with SPSB has been measured to be as low as 240 K, which is much larger than that of 90 K in the laser with GaAs barrier layers. This improvement results from the reduction of carrier leakage from quantum well to barrier layers.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.354274
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  • 8
    Digitale Medien
    Digitale Medien
    Rapid detection and counting of single bacteria in a wide field using a photon-counting TV camera (1991)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 83 (1991), S. 0 
    Details
    ISSN: 1574-6968
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Abstract: Using Escherichia coli as a model bacterium, we tested a photon-counting method for enumeration of bacteria. This method is based on the principle that microscopic sized luminous particles in a wide field can be directly detected and counted using a photon-counting TV camera without the use of a microscope. E. coli cells were labeled with peroxidase and luminescence induced by adding a luminol-based reaction mixture. The number of luminous spots in the TV images was in good agreement with the number of bacterial colonies grown from labeled cells. The results show that our method provides a rapid and easy microbial counting system for such purposes as clinical diagnosis, microbial analysis in food, and environmental assessment.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04445.x-i1
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    A novel method for detection and counting of single bacteria in a wide field using an ultra-high-sensitivity TV camera without a microscope (1991)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology letters 81 (1991), S. 0 
    Details
    ISSN: 1574-6968
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Abstract: We describe a novel method for enumeration of bacteria, based on the principle that small, light emitting particles on a flat surface can be easily and rapidly detected and counted using an ultra-high-sensitivity TV camera. To test this method, we obtained TV images of individual cells of a luminous bacterium on a membrane filter without the use of a microscope. The positions of the luminous points in the TV images were almost the same as the positions of the bacterial colonies after growth. Our results show that the single cells can be efficiently detected and counted by our method if they emit light or can be stimulated to emit light.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1574-6968.1991.tb04774.x
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  • 10
    Digitale Medien
    Digitale Medien
    On tests for the mean direction of the Langevin distribution (1990)
    Springer
    Annals of the Institute of Statistical Mathematics 42 (1990), S. 359-373 
    Details
    ISSN: 1572-9052
    Schlagwort(e): Asymptotic expansion ; central limit theorem ; Langevin distribution ; likelihood ratio criterion ; Watson statistic ; Rao statistic ; modified Wald statistic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract The asymptotic expansions of the distribution of a sum of independent random vectors with Langevin distribution are given. The power functions of the likelihood ratio criterion, Watson statistic, Rao statistic and the modified Wald statistic for testing the hypothesis of the mean direction are obtained asymptotically and a numerical comparison is made.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00050842
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