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  • Articles  (23)
  • Chemistry  (21)
  • etintidine  (2)
  • Wiley-Blackwell  (21)
  • Springer  (2)
  • American Physical Society
  • 2005-2009
  • 1990-1994  (9)
  • 1985-1989  (12)
  • 1970-1974  (2)
  • 1920-1924
  • 1905-1909
  • 1
    Electronic Resource
    Electronic Resource
    Etintidine-propranolol interaction study in humans (1987)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 15 (1987), S. 557-568 
    Details
    ISSN: 1573-8744
    Keywords: etintidine ; propranolol ; 4-hydroxypropranolol ; interaction ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Etintidine HCl is a potent H2 -blocker. The effect of clinical doses of etintidine on the disposition of a single oral dose of propranolol was investigated in 12 normal subjects. This was a double-blind, two-way crossover study. Each subject received etintidine (400 mg) or placebo twice a day with meals for 4 days on two occasions (separated by 4 days). On each occasion, the subjects were fasted overnight on Day 3 and were given an oral dose of Inderal® (40 mg propranolol hydrochloride) 30 min following the administration of the morning dose of etintidine or placebo on Day 4. Blood samples were collected prior to and up to 24 hr following the administration of propranolol. The plasma samples were analyzed for propranolol and 4-hydroxypropranolol by HPLC. Comparison of the pharmacokinetic parameters of propranolol between etintidine and the placebo groups indicates that etintidine significantly increased the AUC0−∞,values (573.5 vs. 146.4 ng·hr/ml, p=0.0001)and prolonged the elimination half-life (4.61 vs. 2.33 hr) of propranolol. Statistical evaluation of the pharmacokinetic parameters of 4-hydroxypropanolol indicates that etintidine also increased the AUC0−24 values (43.8 vs. 16.4 ng·hr/ml, p=0.0028) and prolonged the elimination half-life (4.87 vs. 1.97 hr) of 4-hydroxypropranolol. The data suggest that etintidine, like cimetidine, impaired the elimination of propranolol. Etintidine also protracted the elimination of 4-hydroxypropranolol, an active metabolite of propranolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01068412
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  • 2
    Electronic Resource
    Electronic Resource
    A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in Plasma (1987)
    Springer
    Pharmaceutical research 4 (1987), S. 133-136 
    Details
    ISSN: 1573-904X
    Keywords: etintidine ; high-performance liquid chromatography (HPLC) ; solid extraction ; determination of etintidine in plasma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract This paper describes a new, rapid solid extraction method for the determination of etintidine in plasma. The method employs a semiautomatic sample preparation system. Plasma samples and the internal standard (cimetidine) were applied onto octyl-bonded silica extraction columns. The extraction columns were then subjected to Tris buffer and water wash and were subsequently loaded onto an automatic sample injection system. The contents of the extraction columns were eluted on-line with a mobile phase of acetonitrile:methanol:0.1% ammonium hydroxide (85:10:5, by volume) onto a silica analytical column and detected by UV absorption at 229 nm. The chromatographic condition separates etintidine from some of its metabolites and other endogenous components in plasma. The detection limit for etintidine was 0.02–0.05 µg/ml when 0.2 ml of plasma was used. This method has been used for the determination of plasma etintidine levels in humans and mice after oral administration of etintidine and was found to be suitable for pharmacokinetic/bioavailability studies of etintidine in humans and animals. The method can also be used for the quantitative determination of cimetidine and certain metabolites of etintidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016419019715
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of an N-Acetylated Heparin Pentasaccharide and its anticoagulant activity in comparison with the heparin pentasaccharide with high anti-factor-Xa activity (1989)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 72 (1989), S. 1268-1277 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The synthesis of tri-N-acetylated heparin pentasaccharide 2 is described. It was assembled from five suitably blocked monosaccharide units (3-7). Glucuronic-acid building block 4 was prepared from glucose by direct Jones oxidation of the 6-O-trityl derivative 18. The resulting acid 16 was esterified to 17 in large mounts using methyl chloroformate/base. Trimethylsilyl bromide proved to be an excellent reagent for the hydrolysis of a prop-1-enyl glycoside (19 →21). The pentasaccharide 29 was obtained by a [2 + 2] + 1 synthesis, the glycosylation reactions furnished good to very good yields. The identity of protected oligosaccharides was confirmed by 1H-NMR spectroscopy. Sequential deblocking of the pentasaccharide, O-sulfation, and N-acetylation gave 2 which was shown to exhibit ca. 600 times lower anticoagulant activity than pentasaccharide 1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19890720613
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  • 4
    Electronic Resource
    Electronic Resource
    Heterogeneous nucleation and growth of spherulites from a polycaprolactone (poly(1-oxy-6-oxohexamethylene)) melt (1974)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 175 (1974), S. 2483-2488 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Es wird über den Beginn einer Untersuchung zur Kristallisationskinetik von Polycaprolacton (Poly(1-oxy-6-oxohexamethylene) (1)) berichtet. Die primäre Keimbildung und das primäre Sphärolith-Wachstum aus der Polymerschmelze werden bei hinreichend hohen Temperaturen verfolgt, wodurch sichergestellt ist, daß das Wachstum der Kristallite durch Keimbildung bestimmt ist. Die kinetischen Daten werden weitgehend mit Hilfe des Avrami-Modells interpretiert, welches sich gut auf die Kristallisation von 1 anwenden ließ.
    Notes: A kinetic crystallization study of polycaprolactone (poly(1-oxy-6-oxohexamethylene) (1)) has been initiated to investigate the primary nucleation and primary spherulitic growth from a polymer melt at temperatures that are high enough to insure nucleation-limited crystallite growth. The analysis of the kinetic data is largely made on the basis of an Avrami model which proved to be well suited for the interpretation of the crystallization of 1.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1974.021750821
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  • 5
    Electronic Resource
    Electronic Resource
    Adaptive, global, extended Kalman filters for training feedforward neural networks (1994)
    New York, NY : Wiley-Blackwell
    Journal of Chemometrics 8 (1994), S. 391-407 
    Details
    ISSN: 0886-9383
    Keywords: Neural networks ; Non-linear multivariate regression ; Pattern classification ; Kalman filter ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Finding methods for the optimization of weights in feedforward neural networks has become an ongoing developmental process in connectionist research. The current focus on finding new methods for the optimization of weights is mostly the result of the slow and unreliable convergence properties of the gradient descent optimization used in the original back-propagation algorithm. More accurate and computationally expensive second-order gradient methods have displaced earlier first-order gradient optimization of the network connection weights. The global, extended Kalman filter is among the most accurate and computationally expensive of these second-order weight optimization methods. The iterative, second-order nature of the filter results in a large number of calculations for each sweep of the training set. This can increase the training time dramatically when training is conducted with data sets that contain large numbers of training patterns. In this paper an adaptive variant of the global, extended Kalman filter that exhibits substantially improved convergence properties is presented and discussed. The adaptive mechanism permits more rapid convergence of network training by identifying data that contain redundant information and avoiding calculations based on this redundant information.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cem.1180080605
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  • 6
    Electronic Resource
    Electronic Resource
    Dynamic analysis of a microbial process: A systems engineering approach (1973)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 15 (1973), S. 377-393 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A general mathematical model of the chemostat system is developed in order to define an experimental program of dynamic testing. A glucose-limited culture ofSaccharomyces cerevisiae was grown in a chemostat using chemically defined medium. The chemostat was perturbed from an initial steady state by changes in input glucose concentration, dilution rate, pH, and temperature. Dynamic responses of cell mass, glucose, cell number, RNA, and protein concentrations were measured. A number of simulation techniques were used in developing a dynamic mathematical model and in comparing the developed model with experimental data as well as the Monod model. The resulting model was found to be quantitatively accurate and superior to the Monod model. The developed model was interpreted in the light of cell physiology. Adjustment of intracellular RNA fraction was found to be rate limiting in acceleration of cell specific growth rate.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260150212
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  • 7
    Electronic Resource
    Electronic Resource
    Simultaneous assay of serum vitamin A and vitamin E by high performance liquid chromatography using time-switched UV and fluorimetric detectors (1986)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 9 (1986), S. 281-284 
    Details
    ISSN: 0935-6304
    Keywords: Liquid chromatography, HPLC ; Time-switched detectors ; UV detection ; Fluorimetric detection ; Vitamin A ; Vitamin E ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An HPLC method utilizing a UV and a fluorimetric detector linked in series is described. By use of a simple integrator-controlled time-switched relay, analysis of serum vitamin A and E is accomplished on the same chromatogram and at optimum sensitivity for each detector. A single internal standard (retinyl acetate) monitored only by the UV detector permits measurement of both vitamins over a wide linear range. Precision of the assays is satisfactory, both on a within-day and on a day-to-day basis. Recoveries of both vitamins are virtually 100% whilst sensitivity is 2 μg/L (retinol) and 0.05 mg/L (α-tocopherol).
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240090506
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  • 8
    Electronic Resource
    Electronic Resource
    A new technique for preparing monodisperse polymer particles (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 45 (1992), S. 1783-1788 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A procedure is described for preparing fairly uniform spheres of three different nylon polymers by phase separation. The mean diameter and polydisperse index were 5 μm and 1.056 for Griltex nylon, 5.7 μm and 1.046 for nylon 6/6, and 12.9 μm and 1.016 for nylon 6. The phase separation is done by taking a 1 wt % solution in a theta solvent above the theta temperature and cooling it rapidly. The spheres of the three nylons have various degrees of roughness. Formation of highly uniform particles during phase separation is discussed in a preliminary way. © 1992 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1992.070451012
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  • 9
    Electronic Resource
    Electronic Resource
    Produktzusammensetzung der Kohlenwasserstoffgemische nach der BIRCH-Reduktion substituierter Benzene und säurekatalysierte Addition von Alkoholen an alkylsubstituierte Cyclohexene und Cyclohexa-1,4-diene (1991)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 333 (1991), S. 481-488 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Composition of Mixtures of Hydrocarbons after BIRCH-Reduction of Substituted Benzenes and Acid Catalyzed Addition of Alcohols to Alkylsubstituted Cyclohexenes and Cyclohexa-1,4-dienes.10 different benzene hydrocarbons 1, indane, tetraline, anisol and phenol are reduced by sodium in liquid ammonia in the presence of methanol to the BIRCH products 2. The product mixture compositions are determined through capillary GLC. On storage at + 6°C some rearomatization of the 1,4-cyclohexadienes 2 occurs. Data of the 1H- and 13C-n.m.r. spectra and also mass spectra of the BIRCH 1,4-dienes 2 are given. For comparison 4-alkoxycyclohexenes 4 and 1-alkoxy-1-methylcyclohexanes 8 are prepared and spectroscopically characterized. Acid-catalyzed addition of alcohols to the 1,4-cyclohexadiene systems is a slow process and gives the 4-alkoxy-4-alkylcyclohex-1-enes (4) only in moderate yields up to 30 %. Most of the products are dimers 5 and also oligomers 6 of the parent hydrocarbons 2.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19913330315
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  • 10
    Electronic Resource
    Electronic Resource
    Dreikomponentenreaktionen. XX. Methoxymercurierung von Cyclohexa-1,4-dienen (1991)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 333 (1991), S. 447-453 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Three Component Reactions. XX. Methoxymercuration of Cyclohexa-1,4-dienes.The methoxymercuration of several cyclohexa-1,4-dienes leads to insoluble mixtures of mono- and bismercuricompounds 2-4 and 5-7. After reduction with NaBH4/NaOH mixtures of methoxycyclohexenes and bismethoxycyclohexanes result. The result of capillary gaschromatographic analyses and n.m.r. spectra allow a semiquantitative evaluation of the reaction pathways.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19913330310
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