Publication Date:
1995-06-09
Description:
In mice lacking the interleukin-2 receptor beta chain (IL-2R beta), T cells were shown to be spontaneously activated, resulting in exhaustive differentiation of B cells into plasma cells and the appearance of high serum concentrations of immunoglobulins G1 and E as well as autoantibodies that cause hemolytic anemia. Marked infiltrative granulocytopoiesis was also apparent, and the animals died after about 12 weeks. Depletion of CD4+ T cells in mutant mice rescued B cells without reversion of granulocyte abnormalities. T cells did not proliferate in response to polyclonal activators, nor could antigen-specific immune responses be elicited. Thus, IL-2R beta is required to keep the activation programs of T cells under control, to maintain homeostasis, and to prevent autoimmunity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Suzuki, H -- Kundig, T M -- Furlonger, C -- Wakeham, A -- Timms, E -- Matsuyama, T -- Schmits, R -- Simard, J J -- Ohashi, P S -- Griesser, H -- New York, N.Y. -- Science. 1995 Jun 9;268(5216):1472-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Amgen Institute, Toronto, Ontario, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7770771" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autoantibodies/blood
;
*Autoimmunity
;
B-Lymphocytes/immunology
;
CD4-Positive T-Lymphocytes/immunology
;
Female
;
Heterozygote
;
Homozygote
;
Lymph Nodes/immunology
;
*Lymphocyte Activation
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Nude
;
Mutagenesis, Insertional
;
Myeloproliferative Disorders/immunology
;
Receptors, Interleukin-2/genetics/*physiology
;
Signal Transduction
;
T-Lymphocytes/*immunology
;
T-Lymphocytes, Cytotoxic/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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