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  • 11
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    A toll-like receptor that prevents infection by uropathogenic bacteria (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-03-06
    Description: Toll-like receptors (TLRs) recognize molecular patterns displayed by microorganisms, and their subsequent activation leads to the transcription of appropriate host-defense genes. Here we report the cloning and characterization of a member of the mammalian TLR family, TLR11, that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. Cells expressing TLR11 fail to respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. Mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating a potentially important role for TLR11 in preventing infection of internal organs of the urogenital system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Dekai -- Zhang, Guolong -- Hayden, Matthew S -- Greenblatt, Matthew B -- Bussey, Crystal -- Flavell, Richard A -- Ghosh, Sankar -- GM07205/GM/NIGMS NIH HHS/ -- R01-AI59440/AI/NIAID NIH HHS/ -- R37-AI33443/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Mar 5;303(5663):1522-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15001781" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Line ; Cloning, Molecular ; Codon, Terminator ; Colony Count, Microbial ; Disease Susceptibility ; Epithelial Cells/metabolism ; Escherichia coli/growth & development/immunology/*pathogenicity ; Escherichia coli Infections/*immunology/microbiology ; Gene Expression Profiling ; Humans ; Immunity, Innate ; Kidney/immunology/*metabolism/microbiology ; Ligands ; Liver/metabolism ; Macrophages/metabolism ; Mice ; Mice, Knockout ; Molecular Sequence Data ; NF-kappa B/metabolism ; Polymorphism, Genetic ; Receptors, Cell Surface/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Toll-Like Receptors ; Transfection ; Tumor Necrosis Factor-alpha/metabolism ; Urinary Bladder/immunology/*metabolism/microbiology ; Urinary Tract Infections/*immunology/microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-05-26
    Description: The BRCT repeats of the breast and ovarian cancer predisposition protein BRCA1 are essential for tumor suppression. Phosphopeptide affinity proteomic analysis identified a protein, Abraxas, that directly binds the BRCA1 BRCT repeats through a phospho-Ser-X-X-Phe motif. Abraxas binds BRCA1 to the mutual exclusion of BACH1 (BRCA1-associated C-terminal helicase) and CtIP (CtBP-interacting protein), forming a third type of BRCA1 complex. Abraxas recruits the ubiquitin-interacting motif (UIM)-containing protein RAP80 to BRCA1. Both Abraxas and RAP80 were required for DNA damage resistance, G(2)-M checkpoint control, and DNA repair. RAP80 was required for optimal accumulation of BRCA1 on damaged DNA (foci) in response to ionizing radiation, and the UIM domains alone were capable of foci formation. The RAP80-Abraxas complex may help recruit BRCA1 to DNA damage sites in part through recognition of ubiquitinated proteins.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573690/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573690/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Bin -- Matsuoka, Shuhei -- Ballif, Bryan A -- Zhang, Dong -- Smogorzewska, Agata -- Gygi, Steven P -- Elledge, Stephen J -- 1KO1, CA116275-01/CA/NCI NIH HHS/ -- 1U19A1067751/PHS HHS/ -- T32CA09216/CA/NCI NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2007 May 25;316(5828):1194-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Center for Genetics and Genomics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17525340" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; BRCA1 Protein/*physiology ; Carrier Proteins/*physiology ; Cell Line, Tumor ; *DNA Damage ; *DNA Repair ; HeLa Cells ; Humans ; Mass Spectrometry ; Molecular Sequence Data ; Nuclear Proteins/*physiology ; Protein Binding ; Protein Structure, Tertiary
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 13
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    Divergence of transcription factor binding sites across related yeast species (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-08-11
    Description: Characterization of interspecies differences in gene regulation is crucial for understanding the molecular basis of both phenotypic diversity and evolution. By means of chromatin immunoprecipitation and DNA microarray analysis, the divergence in the binding sites of the pseudohyphal regulators Ste12 and Tec1 was determined in the yeasts Saccharomyces cerevisiae, S. mikatae, and S. bayanus under pseudohyphal conditions. We have shown that most of these sites have diverged across these species, far exceeding the interspecies variation in orthologous genes. A group of Ste12 targets was shown to be bound only in S. mikatae and S. bayanus under pseudohyphal conditions. Many of these genes are targets of Ste12 during mating in S. cerevisiae, indicating that specialization between the two pathways has occurred in this species. Transcription factor binding sites have therefore diverged substantially faster than ortholog content. Thus, gene regulation resulting from transcription factor binding is likely to be a major cause of divergence between related species.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borneman, Anthony R -- Gianoulis, Tara A -- Zhang, Zhengdong D -- Yu, Haiyuan -- Rozowsky, Joel -- Seringhaus, Michael R -- Wang, Lu Yong -- Gerstein, Mark -- Snyder, Michael -- New York, N.Y. -- Science. 2007 Aug 10;317(5839):815-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17690298" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Binding Sites ; Candida albicans/genetics/growth & development/metabolism ; Chromatin Immunoprecipitation ; DNA-Binding Proteins/genetics/metabolism ; *Evolution, Molecular ; Fungal Proteins/genetics/*metabolism ; Gene Expression Regulation, Fungal ; Gene Regulatory Networks ; Genes, Fungal ; Oligonucleotide Array Sequence Analysis ; *Regulatory Sequences, Nucleic Acid ; Saccharomyces/*genetics/growth & development/metabolism ; Saccharomyces cerevisiae/*genetics/growth & development/metabolism ; Saccharomyces cerevisiae Proteins/genetics/metabolism ; Transcription Factors/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Reproduction in a simultaneous hermaphroditic shrimp, Lysmata wurdemanni : any two will do? (2001)
    Springer
    Details
    Publication Date: 2001-12-01
    Print ISSN: 0025-3162
    Electronic ISSN: 1432-1793
    Topics: Biology
    Published by Springer
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  • 15
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    Reproduction in a simultaneous hermaphroditic shrimp, Lysmata wurdemanni : any two will do? (2001)
    Springer
    Details
    Publication Date: 2001-11-01
    Print ISSN: 0025-3162
    Electronic ISSN: 1432-1793
    Topics: Biology
    Published by Springer
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  • 16
    Electronic Resource
    Electronic Resource
    Electrical characterization, metallurgical investigation, and thermal stability studies of (Pd, Ti, Au)-based ohmic contacts (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 2437-2444 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Although Pd/Ti/Pd/Au contacts are similar to their Pt/Ti/Pt/Au counterparts in providing low specific contact resistance, ρc, the former exhibits long-term thermal stability. Their projected mean times to 50% increase in ρc(μ50) at 150 °C to p+-GaAs (≥3.43×1015 h) are higher than those of the latter by over five orders of magnitude. Contacts to p+-In0.53Ga0.47As are not as thermally stable, with a much lower albeit respectable μ50 at 150 °C of ≥2.25×105 h. Contacts with an interfacial Pd layer provide ρc's that are at least two times lower than those without, and the presence of an oxide layer (GaxTiyOz) at the Ti/GaAs interface is identified as a possible cause. Pd–Ga–As phases are formed at the Pd/GaAs interface, being As-rich (PdxGayAs) initially and convert to Ga-rich phases (PduGavAs) upon a high temperature anneal and the eventual composition depends on the evaporated interfacial Pd thickness and annealing conditions. This could probably explain the existence of an optimum interfacial Pd layer thickness of 100 Å for achieving the lowest ρc. The Ga-rich PduGavAs phases formed are inferred to cause the liberation of As atoms from the GaAs lattice, thus enabling them to diffuse out to the Ti and react to form TixAsy phases that bind the As from further out-diffusion. This has in turn led to the accumulation of As at the Pd/Ti interface. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372198
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  • 17
    Electronic Resource
    Electronic Resource
    Synthesis and reactivity of Fe nanoparticles embedded in a semi-insulating matrix (2000)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 87 (2000), S. 7213-7217 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The technique of plasma enhanced chemical vapor deposition has been used to synthesize Fe nanoparticles in an amorphous boron carbide matrix. The nanoparticles range in size from approximately 0.7 to 4.5 nm. It has been demonstrated that the size of the nanoparticles is proportional to the density of the Fe precursor (ferrocene) in the vapor. The matrix films have been found to be extremely hygroscopic. Upon absorption of moisture the films buckle and delaminate from the Si substrate. The buckling is a consequence of induced strain arising from the transformation of the Fe nanoparticles into α-Fe2O3. The formation of α-Fe2O3 has been verified by electron diffraction and near edge x-ray absorption fine structure measurements. Examination of the magnetic properties of the α-Fe2O3 using the technique of magnetic circular dichroism indicate that the nanoparticles are not ferromagnetic. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.372971
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  • 18
    Electronic Resource
    Electronic Resource
    Electrical characterization and metallurgical analysis of Pd-containing multilayer contacts on GaN (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 90 (2001), S. 1242-1249 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Ti(250 Å)/Al(2200 Å)/Pd(600 Å)/Au(1600 Å) contact on aqua-regia surface treated n-GaN (Si∼1.0×1019 cm−3) has yielded a minimum specific contact resistance (ρc) of 4.21×10−8 Ω cm2, achieved after thermal annealing at 500 °C for 8 min. This is superior to the most common n-GaN contact, Ti/Al, which has also been studied in the current work and produced a lowest ρc of 4.63×10−6 Ω cm2, obtained after annealing at 700 °C for 2 min. The long-term thermal stability analysis has also revealed that the Ti/Al/Pd/Au contact is more stable than Ti/Al on n-GaN. The projected mean time to 50% increase in ρc(μ50) at 150 °C for the former is 1.22×1012 h, which is higher by about three orders of magnitude than that of the latter at 3.54×109 h. Pd(200 Å)/Ni(300 Å)/Au(2000 Å) contact on boiling aqua-regia surface treated p-GaN (Mg∼1.0×1018 cm−3) has also been investigated and demonstrated a reasonable ohmic behavior with a ρc of 5.03×10−4 Ω cm2 after thermal annealing at 450 °C for 2 min. However, its thermal stability is mediocre with μ50 at 150 °C of only 1.49×103 h. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1383977
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  • 19
    Electronic Resource
    Electronic Resource
    Intersubband absorption from InGaAlAs/InAlAs multiple quantum-well structures grown by molecular-beam epitaxy (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 3579-3581 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The intersubband absorption from the InGaAlAs/InAlAs multiple quantum-well structures, lattice matched to InP, for the long-wavelength infrared detection has been investigated. It is found that the strong absorption resulting from the bound-to-bound transition in the quaternary material is observable and the wavelength of the absorption varies with the well width while the barrier width remains unchanged. The photoluminescence results indicate that the absorption originates from the transition of the electrons from the ground energy level to the first excited energy level in the conduction band of the well material. Our experimental results are also in good agreement with the theoretical estimation based on the simple finite barrier model. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126712
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  • 20
    Electronic Resource
    Electronic Resource
    Nanosprings (2001)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 79 (2001), S. 1540-1542 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The transition from linear to helical growth of amorphous boron carbide nanowires has been examined with high-resolution transmission electron microscopy. Based on the observed changes of the iron catalyst at the transition point from linear to helical growth, a model of helical growth of solid nanowires has been developed based on the work of adhesion of the metallic catalyst to the tip of the nanowire. This model demonstrates that contact angle anisotropy at the catalyst/wire interface drives helical growth. The anisotropy is introduced when the radius of the droplet (R) exceeds the radius of the nanowire (ρ), and the center of mass of the metal droplet is displaced laterally from the central axis of the nanowire. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1400079
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