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  • Meteorology and Climatology  (1)
  • collagen degradation  (1)
  • orosomucoid  (1)
  • 2005-2009  (1)
  • 2000-2004  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of experimental biology and medicine 129 (2000), S. 1-6 
    ISSN: 1573-8221
    Keywords: hepatocyte ; CCl 4 ; collagen degradation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Partial hepatectomy of mouse cirrhotic liver leads to rapid degeneration of hypertrophied connective tissue. Enlarged cisterns of the smooth endoplasmic reticulum lie close to the plasma membrane on the sinusoidal surface of hepatocyte. Golgi apparatus of Kupffer cells is hypertrophied, swollen collagen fibrils lose their specific striation. Microvilli of hepatocyte plasmalemma separate swollen collagen fibrils and draw them into the cytoplasm. Lysosomes, peroxisomes, and hypertrophied Golgi apparatus are spread from the sinusoidal surface to bile capillaries, which indicates that these structures are involved in collagen lysis and release of metabolites into the bile capillary. After partial hepatectomy of cirrhotic liver, hepatocytes, Kupffer cells, and neutrophils play the major role in collagen lysis. Kupffer cells and neutrophils are involved in the lysis of collagen fibrils during CCl4-induced liver cirrhosis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-8221
    Keywords: α1-acid glycoprotein ; neoglycoconjugates ; Inflammation ; immunomodulation ; complement ; orosomucoid ; free radicals ; tumor necrosis factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Pseudo-α1-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of α1-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the semisynthetic analog inhibited lymphocyte proliferation and stimulated the production of antiinflammatory cytokines by peripheral blood mononuclear leukocytes. However, it possessed no antioxidant activity and did not inhibit complement activation by the alternative pathway. The role of carbohydrate and protein components of α1-acid glycoprotein molecule in the realization of its biological effects is discussed.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2018-06-11
    Description: An understanding of the effect of aerosols on biologically- and photochemically-active UV radiation reaching the Earth's surface is important for many ongoing climate, biophysical, and air pollution studies. In particular, estimates of the UV characteristics of the most common Australian aerosols will be valuable inputs to UV Index forecasts, air quality studies, and assessments of the impact of regional environmental changes. By analyzing climatological distributions of Australian aerosols we have identified sites where co-located ground-based UV-B and ozone measurements were available during episodes of relatively high aerosol activity. Since at least June 2003, surface UV global irradiance spectra (285-450 nm) have been measured routinely at Darwin and Alice Springs in Australia by the Australian Bureau of Meteorology (BoM). Using colocated sunphotometer measurements at Darwin and Alice Springs, we identified several episodes of relatively high aerosol activity. Aerosol air mass types were analyzed from sunphotometer-derived angstrom parameter, MODIS fire maps and MISR aerosol property retrievals. To assess aerosol effects we compared the measured UV irradiances for aerosol-loaded and clear-sky conditions with each other and with irradiances simulated using the libRadtran radiative transfer model for aerosol-free conditions. We found that for otherwise similar atmospheric conditions, smoke aerosols over Darwin reduced the surface UV irradiance by as much as 40-50% at 290-300 nm and 20-25% at 320-400 nm near active fires (aerosol optical depth, AOD, at 500 nm approximately equal to 0.6). Downwind of fires, the smoke aerosols over Darwin reduced the surface irradiance by 15-25% at 290-300 nm and approximately 10% at 320-350 nm (AOD at 500 nm approximately equal to 0.2). The effect of smoke increased with decrease of wavel strongest in the UV-B. The aerosol attenuation factors calculated for the selected cases suggest smoke over Darwin has an effect on surface 340-380 nm irradiances that is comparable to that produced by smoke over Sub-Saharan Africa. Dust activity was very low at Alice Springs during 2004, therefore we were not able to identify strong dust events to fully assess the UVeffect of dust. For the cases studied, smoke aerosols seem to produce a stronger reduction in surface UV irradiances than dust aerosols.
    Keywords: Meteorology and Climatology
    Type: Remote Sensing of Environment: Multi-angle Imaging SpectroRadiometer (MISR) Special Issue; Volume 107; Issues 1-2; 65-80
    Format: text
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