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  • Neurons/*physiology  (3)
  • Himalayas  (2)
  • 2005-2009  (2)
  • 2000-2004  (3)
  • 1920-1924
  • 1
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    Comparative morphotectonics in the Himalayan foreland and the forearc of Southwest Japan. The 19th Himalaya-Karakorum-Tibet Workshop (2004)
    In:  Himalayan Journal of Sciences, Special Issue, pp. 182, vol. 2
    Details
    Publication Date: 2004
    Keywords: CC 1/1 ; Coordinating Committee ; Himalayas
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    BIBLIOGRAPHY ILP
  • 2
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    Maximum extent of the Paleo-Kathmandu Lake in the late Pleistocene on the basis of piedmont gentle slope formation and lacustrine distribution in the Kathmandu basin, Nepal. The 19th Himalaya-Karakorum-Tibet Workshop (2004)
    In:  Himalayan Journal of Sciences, Special Issue, pp. 239, vol. 2
    Details
    Publication Date: 2004
    Keywords: CC 1/1 ; Coordinating Committee ; Himalayas
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  • 3
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    Regulation of C. elegans life-span by insulinlike signaling in the nervous system (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-10-06
    Description: An insulinlike signaling pathway controls Caenorhabditis elegans aging, metabolism, and development. Mutations in the daf-2 insulin receptor-like gene or the downstream age-1 phosphoinositide 3-kinase gene extend adult life-span by two- to threefold. To identify tissues where this pathway regulates aging and metabolism, we restored daf-2 pathway signaling to only neurons, muscle, or intestine. Insulinlike signaling in neurons alone was sufficient to specify wild-type life-span, but muscle or intestinal signaling was not. However, restoring daf-2 pathway signaling to muscle rescued metabolic defects, thus decoupling regulation of life-span and metabolism. These findings point to the nervous system as a central regulator of animal longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolkow, C A -- Kimura, K D -- Lee, M S -- Ruvkun, G -- AG14161/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):147-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11021802" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/genetics/*physiology ; Animals ; Caenorhabditis elegans/genetics/*physiology ; *Caenorhabditis elegans Proteins ; Catalase/genetics/metabolism ; Gene Expression Regulation ; Genes, Helminth ; Helminth Proteins/genetics/metabolism ; Intestines/cytology/physiology ; Larva/physiology ; Longevity ; Muscles/cytology/physiology ; Nervous System Physiological Phenomena ; Neurons/*physiology ; Phenotype ; *Phosphatidylinositol 3-Kinases ; Promoter Regions, Genetic ; Receptor, Insulin/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Superoxide Dismutase/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Representation of action-specific reward values in the striatum (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-11-29
    Description: The estimation of the reward an action will yield is critical in decision-making. To elucidate the role of the basal ganglia in this process, we recorded striatal neurons of monkeys who chose between left and right handle turns, based on the estimated reward probabilities of the actions. During a delay period before the choices, the activity of more than one-third of striatal projection neurons was selective to the values of one of the two actions. Fewer neurons were tuned to relative values or action choice. These results suggest representation of action values in the striatum, which can guide action selection in the basal ganglia circuit.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Samejima, Kazuyuki -- Ueda, Yasumasa -- Doya, Kenji -- Kimura, Minoru -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1337-40.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computational Neurobiology, ATR Computational Neuroscience Laboratories, 619-0288 Kyoto, Japan. samejima@lab.tamagawa.ac.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311337" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Brain Mapping ; Caudate Nucleus/*physiology ; *Choice Behavior ; Corpus Striatum/*physiology ; Female ; Macaca ; Male ; Neurons/*physiology ; Probability ; Putamen/*physiology ; Regression Analysis ; Reinforcement (Psychology) ; *Reward
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Complementary process to response bias in the centromedian nucleus of the thalamus (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-06-18
    Description: Activity in several areas of the human brain and the monkey brain increases when a subject anticipates events associated with a reward, implicating a role for bias of decision and action. However, in real life, events do not always appear as expected, and we must choose an undesirable action. More than half of the neurons in the monkey centromedian (CM) thalamus were selectively activated when a small-reward action was required but a large-reward option was anticipated. Electrical stimulation of the CM after a large-reward action request substituted a brisk performance with a sluggish performance. These results suggest involvement of the CM in a mechanism complementary to decision and action bias.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Minamimoto, Takafumi -- Hori, Yukiko -- Kimura, Minoru -- New York, N.Y. -- Science. 2005 Jun 17;308(5729):1798-801.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15961671" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Decision Making ; Electric Stimulation ; Electrophysiology ; Macaca ; Neurons/*physiology ; Probability ; Reaction Time ; *Reward ; Task Performance and Analysis ; Thalamic Nuclei/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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