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  • Articles  (7)
  • Canadian Science Publishing  (5)
  • Blackwell Publishing Ltd
  • 2005-2009  (4)
  • 2000-2004  (3)
  • 1965-1969
  • 1935-1939
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  • Articles  (7)
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  • 1
    Electronic Resource
    Electronic Resource
    Cell surface presentation of recombinant (poly-) peptides including functional T-cell epitopes by the AIDA autotransporter system (2000)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 27 (2000), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: For the efficient surface presentation and release of virulence factors especially pathogenic Gram-negative bacteria have developed several distinct secretion mechanisms. An increasing number of pathogens in various species employs a mechanism denoted the ‘autotransporter’ pathway. This pathway is characterised by an outer membrane translocator module representing the C-terminal domain of the transported protein itself. An intriguing potential application of such systems involves the transport and surface expression of recombinant proteins or peptides, like e.g. the presentation of antigens for the generation of live oral vectors as vaccine carriers. Here we report on the incorporation of heterologous (poly-) peptides in permissive sites of the translocator module of the adhesin-involved-in-diffuse-adherence (AIDA) autotransporter system. We demonstrate the presentation of the B subunit of the heat labile enterotoxin of Escherichia coli (LTB) as well as of functional T-cell epitopes of Yersinia enterocolitica heat-shock protein 60 (Y-hsp60) on the surface of E. coli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1574-695X.2000.tb01446.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules (2005)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 43 (2005), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: The development of novel approaches that allow accurate targeting of therapeutics to the intestinal mucosa is a major task in the research on intestinal inflammation. For the first time, a live genetically modified bacterial strain has been approved by Dutch authorities as a therapeutic agent for experimental therapy of intestinal bowel disease (IBD) in humans. Genetically modified probiotics can very well be used as carriers for localized antigen delivery into the intestine. Therapeutic safety, however, of such a carrier organism, is crucial, especially when a specific probiotic strain has to be used under diseased conditions. In this study, we tested the potential of Escherichia coli NISSLE 1917 to serve as a safe carrier for targeted delivery of recombinant proteins to the intestinal mucosa. In a well-defined and very sensitive immunological system, we demonstrate that intestinal recombinant E. coli NISSLE 1917 has no effect on migration, clonal expansion and activation status of specific CD4+ T cells, neither in healthy mice nor in animals with acute colitis. Furthermore, recombinant E. coli NISSLE 1917 has no effect on the induction or breakdown of peripheral T-cell tolerance in an autoimmune environment. The excellent colonization properties of E. coli NISSLE 1917 render this strain an ideal candidate as carrier organism for gut-focused in situ synthesis of therapeutic molecules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsim.2004.10.023
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  • 3
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    Soil microclimate and nitrogen availability 10 years after mechanical site preparation in northern British Columbia (2005)
    Canadian Science Publishing
    Details
    Publication Date: 2005-08-01
    Description: Mechanical site preparation (MSP) changes the distribution and character of forest floor and mineral soil and may affect soil nutrient availability, soil water content, and soil temperature. The effects of different kinds of MSP were compared to a control in the tenth growing season at two research sites in northern British Columbia. To compare MSP results with those of the natural disturbance regime, a burned windrow treatment was also included in the analysis. The bedding plow, fire, and madge treatments all had significantly greater crop-tree growth compared to the control. The bedding plow and madge treatments had significantly lower soil bulk density, higher soil temperature, and lower soil water throughout the growing season compared with that of the control. The bedding plow also resulted in significantly higher concentrations of total carbon, total nitrogen, NH4+, and NO3than that of the control, at both the 010 and 1020 cm depths. The madge rotoclear resulted in significantly greater potential mineralizable N than that of the control. Ionic resins bags, installed for one growing season, did not show any significant treatment differences in available soil nitrogen. MSP did not reduce soil fertility on these sites when compared with an untreated control, but it is difficult to say that it improved it.
    Print ISSN: 0045-5067
    Electronic ISSN: 1208-6037
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Canadian Science Publishing
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  • 4
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    Mechanical disturbance impacts on soil properties and lodgepole pine growth in British Columbia’s central interior (2005)
    Canadian Science Publishing
    Details
    Publication Date: 2005-11-01
    Description: Forest landings are areas located adjacent to haul roads where harvested trees that were skidded from the cutblock are processed and loaded onto trucks. Soils on landings are often excessively compacted by heavy timber harvesting machinery and may take many years to recover from such disturbance. This study examined soil properties and tree growth on unrehabilitated landings (with and without natural regeneration) and adjacent naturally regenerated clearcuts in the central interior of British Columbia (BC), 23 yr after landing construction. Landings (both with and without natural regeneration) had less favorable conditions for tree growth than did clearcuts, including significantly greater surface soil bulk density and mechanical resistance (on some dates) and lower total porosity and concentrations of C and N. Landings without natural regeneration had the least favorable soil conditions, which may account for the lack of natural regeneration. Lodgepole pine (Pinus contorta Dougl. ex Loud. var. latifolia Engelm.) growing on portions of the landings did not differ in height from those growing in adjacent clearcuts. Site index, as estimated using the growth intercept method, did not differ between naturally regenerated landings (21.7 m) and clearcuts (22.0 m), suggesting that the soils may be equally capable of supporting productive forests. Key words: Forest soil disturbance, soil mechanical resistance, soil productivity, soil water content, natural regeneration
    Print ISSN: 0008-4271
    Electronic ISSN: 1918-1841
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Canadian Science Publishing
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  • 5
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    The influence of understory vine maple on forest floor and mineral soil properties in coastal temperate forests (2003)
    Canadian Science Publishing
    Details
    Publication Date: 2003-02-01
    Description: In coastal forests of the Pacific Northwest, vine maple (Acer circinatum Pursh) is a common understory tree species. We studied the influence of vine maple, growing in the understory of a stand of Douglas-fir [Pseudotsuga menziesii (Mirb.) Franco] and western hemlock [Tsuga heterophylla (RAF.) Sarg.], on forest floor and mineral soil properties. Fifteen (in a 75-yr-old stand) and 12 (in a 130-yr-old stand) plots containing vine maple were compared to paired plots without the influence of vine maple. Mull humus was dominant under vine maples, while mor humus was mainly found under conifers at the 130 yr-old stand. Common to both stands in the upper mineral soil were greater mineralizable N and total exchangeable bases under vine maple. At the 75-yr-old stand, the forest floor had a higher pH and greater total exchangeable base concentration, while the mineral soil had a lower C:N ratio, greater NO3-availability and lower available P concentration and content under vine maple compared to conifers. The 130-yr-old stand had less available P content and greater concentrations of mineralizable N and exchangeable Mg in the forest floor under vine maple. Results suggest that the presence of vine maple may enhance the availability of N and exchangeable bases, but may adversely affect P availability. Key words: Vine maple, soil-plant interactions, forest floor, Acer circinatum
    Print ISSN: 0008-4271
    Electronic ISSN: 1918-1841
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Canadian Science Publishing
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  • 6
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    Spatial patterns of forest floor properties and litterfall amounts associated with bigleaf maple in conifer forest of southwestern British Columbia (2008)
    Canadian Science Publishing
    Details
    Publication Date: 2008-05-02
    Description: This study was aimed at detecting the spatial characteristics of forest floor properties and litterfall amounts related to bigleaf maple (Acer macrophyllum Pursh) within conifer forest. Two 36-m × 36-m plots, centered on individual dominant bigleaf maple stems, were sampled at 129 systematic locations and tested for forest floor pH, cation exchange capacity, exchangeable cations, and mineralizable N. Tree stem location, forest floor horizon depths and litterfall amounts were measured. The kriging approach was used to visualize overall spatial patterns, Moran's I was used to give a global measure of spatial autocorrelation over the sampled region, and local indicators of spatial association (LISA) was used to detect and locate significant spatial clustering of similar values at the local scale. Most soil chemical properties had higher values in locations adjacent to the bigleaf maple stem, up to distances of 2.5 m from the stem on both study plots, and all exchangeable cations were positively spatially autocorrelated (P 〈 0.05) up to distances of 4 m. The majority of bigleaf maple litter (84% on plot 1, 92% on plot 2) was found to be deposited directly beneath the canopy extent. This study provides an understanding of the underlying spatial patterns of bigleaf maple influence on soil properties at plot scale. Key words: Bigleaf maple, spatial analysis, broadleaf species, plant-soil interactions local indicators of spatial association, forest floor
    Print ISSN: 0008-4271
    Electronic ISSN: 1918-1841
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Canadian Science Publishing
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  • 7
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    Spacial patterns of soil temperature and moisture across subalpine forest-clearcut edges in the southern interior of British Columbia (2003)
    Canadian Science Publishing
    Details
    Publication Date: 2003-02-01
    Description: To investigate if timber harvesting influences spatial patterns of soil micro climate, forest floor soil temperature and moisture were examined across forest-clearcut edges. Transects were sampled during the 2000 growing season across a 1-ha clearcut at a subalpine forest site in the southern interior of British Columbia, Canada. Forest floor temperature measurements were made twice, once under sunny and once under overcast conditions. Moisture status, measured under wet and dry conditions, was expressed as gravimetric and volumetric moisture content and matric potential. Wavelet analysis was used to detect and compare the location of edges in soil properties, and variance partitioning was used to examine the environmental and spatial sources of variability in temperature and moisture. Based on the wavelet analyses, the transition zone, in both temperature and moisture between forest and clearcut occurred at 7–15 m into the clearcut from the south edge and at 8–18 m into the forest from the north edge. Spatial patterns were consistent between clear and overcast conditions and wet and dry conditions. Distance from the edge was a minor source of spatial variability in temperature and moisture relative to the strong contrast between forest and clearcut conditions. The edge influences may have implications for nutrient cycling, plant available water and forest regeneration. Key words: Soil temperature, soil moisture, forest floor, subalpine forest, wavelet analysis, edge effects
    Print ISSN: 0008-4271
    Electronic ISSN: 1918-1841
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Canadian Science Publishing
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