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  • Female
  • Geophysics
  • Mice
  • Models, Molecular
  • Springer  (2)
  • 2005-2009
  • 2000-2004
  • 1995-1999  (2)
  • 1
    ISSN: 1432-0878
    Schlagwort(e): Key words: Skeletal muscle ; Regeneration ; Ageing ; Strain-specific muscle precursor replication ; Autoradiography ; Mice ; BALBc (SJL/J)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract. The patterns of skeletal muscle precursor cell replication after crush injury were compared by the use of autoradiographic techniques, in young (4-week-old) and old (39-week-old) BALBc and SJL/J mice. Similar comparisons were made between cut and crush lesions in old BALBc muscle. Muscle precursor cell replication commenced at 18–24 h after injury in both young and old muscles from both strains of mice. In young BALBc muscle the peak of myogenic activity at 60 h was 36 h earlier than in old mice. SJL/J muscle responded more rapidly than did BALBc: in young SJL/J the peak myogenic activity was at 46 h (14 h earlier than in young BALBc muscle), and in old SJL/J muscle the peak activity at 72 h was 24 h earlier than in old BALBc muscle. In all mice (both young and old) myogenic cell replication was substantially reduced by 120 h after injury. A comparison of the timing of muscle precursor cell replication in cut and crush lesions in old BALBc mice revealed a more rapid response in the cut lesion; this difference between the lesions is comparable with data from identical lesions in 6–8-week-old BALBc mice (McGeachie and Grounds 1987). However, the peak of myogenic replication in the older mice in the present study was some 26–36 h later than in the younger 6–8-week-old mice. These experiments show that, whilst muscle precursor cell replication commences at approximately the same time (about 24 h) after injury in young and old mice, the peak level of activity is delayed by some 24–36 h in old mice. In addition, the SJL/J mouse strain responds more rapidly and prolifically to muscle injury than does the BALBc strain.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    ISSN: 1610-2924
    Schlagwort(e): Geophysics ; Numerical modelling ; Visualization ; Language ; Convection
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Geologie und Paläontologie
    Notizen: Abstract It was known that deep within numbers and binary data from simulations of geophysical convective flows resided various patterns. Two models of convective fluid flows were being considered. One was a model of two-dimensional (768 × 256) air convection with finite Prandtl number of one and Rayleigh number of 108−1010, and another was a model of three-dimensional (up to 120 × 120 × 90) mantle convection with infinite Prandtl number and Rayleigh number of 106−108. Clearly, phenomena existed which superceded each individual dimensionless computer model to provide a piece of information regarding actual fluid flows. The problem was how to find, prove, and communicate these patterns and phenomena for convection simulations with gigabytes of data. In a search for such an analytical and communicative tool, the alternative of visualization was considered. The need for visualization was recognized and discussed. Then, utilizing both two- and three-dimensional models of high Rayleigh number convection, basic techniques of style and content were developed. Applications of the visualization techniques were designed utilizing IBM’s Data Explorer in order to create communicative images and movies, and after the applications, the problems of data storage and transfer became apparent. Throughout the process though, it became clear how important the language of vision actually could be in the geophysics community. In a field in which words such as plumes and internal waves have in ways replaced mathematics as the basic language for science, there is a need for another resource, another language-the visualization of convective fluid flows.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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