Publication Date:
2014-07-19
Description:
The phosphatidylinositol 3-kinase (PI3K) pathway regulates many cellular functions, but its roles in the nervous system are still poorly understood. We found that a newly discovered insulin receptor isoform, DAF-2c, is translocated from the cell body to the synaptic region of the chemosensory neuron in Caenorhabditis elegans by a conditioning stimulus that induces taste avoidance learning. This translocation is essential for learning and is dependent on the mitogen-activated protein kinase-regulated interaction of CASY-1 (the calsyntenin ortholog) and kinesin-1. The PI3K pathway is required downstream of the receptor. Light-regulated activation of PI3K in the synaptic region, but not in other parts of the cell, switched taste-attractive behavior to taste avoidance, mimicking the effect of conditioning. Thus, synaptic PI3K is crucial for the behavioral switch caused by learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ohno, Hayao -- Kato, Shinya -- Naito, Yasuki -- Kunitomo, Hirofumi -- Tomioka, Masahiro -- Iino, Yuichi -- New York, N.Y. -- Science. 2014 Jul 18;345(6194):313-7. doi: 10.1126/science.1250709.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. JST, CREST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. ; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. ; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. Molecular Genetics Research Laboratory, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. ; Molecular Genetics Research Laboratory, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. seidai@gen.s.u-tokyo.ac.jp iino@bs.s.u-tokyo.ac.jp. ; Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. JST, CREST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Molecular Genetics Research Laboratory, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan. seidai@gen.s.u-tokyo.ac.jp iino@bs.s.u-tokyo.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25035490" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Behavior, Animal/*physiology
;
Caenorhabditis elegans/genetics/*physiology
;
Caenorhabditis elegans Proteins/genetics/metabolism/*physiology
;
Learning/*physiology
;
Light
;
Phosphatidylinositol 3-Kinases/genetics/*physiology
;
Protein Isoforms/metabolism
;
Receptor, Insulin/metabolism
;
Synapses/*enzymology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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