Publication Date:
2014-04-11
Description:
Article JNK pathway-associated phosphatase (JKAP) is a dual-specificity phosphatase known to regulate substrates in several signalling cascades. Here, Li et al . demonstrate that JKAP has a key role in negative regulation of proximal T-cell receptor signalling and suppression of T-cell-mediated autoimmunity. Nature Communications doi: 10.1038/ncomms4618 Authors: Ju-Pi Li, Chia-Yu Yang, Huai-Chia Chuang, Joung-Liang Lan, Der-Yuan Chen, Yi-Ming Chen, Xiaohong Wang, Alice J. Chen, John W. Belmont, Tse-Hua Tan
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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