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  • 1
    Publication Date: 2012-06-21
    Description: Author(s): M. Xu, Q. Q. Ge, R. Peng, Z. R. Ye, Juan Jiang, F. Chen, X. P. Shen, B. P. Xie, Y. Zhang, A. F. Wang, X. F. Wang, X. H. Chen, and D. L. Feng Although a nodeless superconducting gap has been observed on the large Fermi pockets around the zone corner in K x Fe 2− y Se 2 , whether its pairing symmetry is s wave or nodeless d wave is still under intense debate. Here we report an isotropic superconducting gap distribution on the small electron Fermi... [Phys. Rev. B 85, 220504] Published Wed Jun 20, 2012
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 2
    Publication Date: 2013-10-15
    Description: Author(s): J. Ge, J. Gutierrez, J. Li, J. Yuan, H.-B. Wang, K. Yamaura, E. Takayama-Muromachi, and V. V. Moshchalkov We have used the ac magnetic susceptibility to investigate the vortex state in an optimally doped p -type Ba 0.5 K 0.5 Fe 2 As 2 single crystal under various ac and dc fields. A peak effect is observed in the temperature dependence of the in-phase ac susceptibility, indicating an order-disorder transition o... [Phys. Rev. B 88, 144505] Published Mon Oct 14, 2013
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 3
    Publication Date: 2011-09-21
    Description: Author(s): Andrew Nicholson, Qinlong Luo, Weihao Ge, José Riera, Maria Daghofer, George B. Martins, Adriana Moreo, and Elbio Dagotto To understand the role that degeneracy, hybridization, and nesting play in the magnetic and pairing properties of multiorbital Hubbard models we here study numerically two types of two-orbital models, both with holelike and electron-like Fermi surfaces (FS's) that are related by nesting vectors ( π ,0... [Phys. Rev. B 84, 094519] Published Tue Sep 20, 2011
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 4
    Publication Date: 2012-01-25
    Description: Author(s): Andrew Nicholson, Weihao Ge, José Riera, Maria Daghofer, Adriana Moreo, and Elbio Dagotto The hole-doped ground state of a recently introduced extended “ t - U - J ” two-orbital Hubbard model for the Fe-based superconductors is studied via exact diagonalization methods on small clusters. Similarly as in the previously studied case of electron doping [ A. Nicholson et al. Phys. Rev. Lett. 106 ... [Phys. Rev. B 85, 024532] Published Tue Jan 24, 2012
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 5
    Publication Date: 2014-07-15
    Description: Author(s): Jun Li, Jie Yuan, Min Ji, Gufei Zhang, Jun-Yi Ge, Hai-Luke Feng, Ya-Hua Yuan, Takeshi Hatano, Wei Hu, Kui Jin, Tobias Schwarz, Reinhold Kleiner, Dieter Koelle, Kazunari Yamaura, Hua-Bing Wang, Pei-Heng Wu, Eiji Takayama-Muromachi, Johan Vanacken, and Victor V. Moshchalkov We investigated the normal-state resistivity ρxx(T) and the Hall effect in Zn- and Co-doped Ba0.5K0.5Fe2As2 single-crystalline microbridges. A crossover temperature T* was observed in the temperature dependency of the longitudinal resistivity ρxx(T), which separates ρxx(T) into temperature-linear an... [Phys. Rev. B 90, 024512] Published Mon Jul 14, 2014
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 6
    Publication Date: 2014-11-15
    Description: Author(s): Jun-Yi Ge, Joffre Gutierrez, A. Lyashchenko, V. Filipov, Jun Li, and Victor V. Moshchalkov In nature, many systems exhibit modulated phases with periodic macroscopic patterns and textures mainly due to the competitive interactions of different phases. Vortex systems in superconductors, which are easy to access, offer the possibility of tuning the ratio between the competitive interactions... [Phys. Rev. B 90, 184511] Published Fri Nov 14, 2014
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
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  • 7
    Publication Date: 2010-07-31
    Description: Programmed genetic rearrangements in lymphocytes require transcription at antigen receptor genes to promote accessibility for initiating double-strand break (DSB) formation critical for DNA recombination and repair. Here, we showed that activated B cells deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired trimethylation of histone 3 at lysine 4 (H3K4me3) and transcription initiation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus, leading to defective immunoglobulin class switching. We also showed that PTIP accumulation at DSBs contributes to class switch recombination (CSR) and genome stability independently of Igh switch transcription. These results demonstrate that PTIP promotes specific chromatin changes that control the accessibility of the Igh locus to CSR and suggest a nonredundant role for the MLL3-MLL4 complex in altering antibody effector function.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008398/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008398/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniel, Jeremy A -- Santos, Margarida Almeida -- Wang, Zhibin -- Zang, Chongzhi -- Schwab, Kristopher R -- Jankovic, Mila -- Filsuf, Darius -- Chen, Hua-Tang -- Gazumyan, Anna -- Yamane, Arito -- Cho, Young-Wook -- Sun, Hong-Wei -- Ge, Kai -- Peng, Weiqun -- Nussenzweig, Michel C -- Casellas, Rafael -- Dressler, Gregory R -- Zhao, Keji -- Nussenzweig, Andre -- Z01 AR041149-03/Intramural NIH HHS/ -- Z01 AR041149-04/Intramural NIH HHS/ -- Z01 DK047055-01/Intramural NIH HHS/ -- Z01 DK047055-02/Intramural NIH HHS/ -- Z01 DK075003-04/Intramural NIH HHS/ -- Z01 DK075003-05/Intramural NIH HHS/ -- Z99 DK999999/Intramural NIH HHS/ -- ZIA AR041149-05/Intramural NIH HHS/ -- ZIA DK075017-03/Intramural NIH HHS/ -- ZIADK047055-03/DK/NIDDK NIH HHS/ -- ZIADK075003-06/DK/NIDDK NIH HHS/ -- ZIADK075017-01/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Aug 20;329(5994):917-23. doi: 10.1126/science.1187942. Epub 2010 Jul 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Immunology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20671152" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibody Specificity/genetics ; Carrier Proteins/genetics/*physiology ; Cytidine Deaminase/metabolism ; Dna ; Histones/metabolism ; Immunoglobulin Class Switching/genetics/*physiology ; Immunoglobulin Switch Region ; Methylation ; Mice ; Nuclear Proteins/genetics/*physiology ; Promoter Regions, Genetic ; Recombination, Genetic ; Transcriptional Activation
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2010-07-24
    Description: DNA methylation at proximal promoters facilitates lineage restriction by silencing cell type-specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such nonproximal promoter DNA methylation are unclear. Here we show that the de novo DNA methyltransferase Dnmt3a is expressed in postnatal neural stem cells (NSCs) and is required for neurogenesis. Genome-wide analysis of postnatal NSCs indicates that Dnmt3a occupies and methylates intergenic regions and gene bodies flanking proximal promoters of a large cohort of transcriptionally permissive genes, many of which encode regulators of neurogenesis. Surprisingly, Dnmt3a-dependent nonproximal promoter methylation promotes expression of these neurogenic genes by functionally antagonizing Polycomb repression. Thus, nonpromoter DNA methylation by Dnmt3a may be used for maintaining active chromatin states of genes critical for development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539760/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539760/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wu, Hao -- Coskun, Volkan -- Tao, Jifang -- Xie, Wei -- Ge, Weihong -- Yoshikawa, Kazuaki -- Li, En -- Zhang, Yi -- Sun, Yi Eve -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Jul 23;329(5990):444-8. doi: 10.1126/science.1190485.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA 90095, USA. haowu7@gmail.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20651149" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Binding Sites ; Brain/cytology/growth & development/*metabolism ; Chromatin Immunoprecipitation ; DNA (Cytosine-5-)-Methyltransferase/*metabolism ; *DNA Methylation ; DNA, Intergenic ; Gene Expression Profiling ; *Gene Expression Regulation, Developmental ; Genome ; Histones/genetics/metabolism ; Mice ; Mice, Knockout ; Nervous System/growth & development ; Neurogenesis/*genetics ; Neuroglia/cytology ; Neurons/*cytology/metabolism ; Polycomb-Group Proteins ; Promoter Regions, Genetic ; Repressor Proteins/metabolism ; Stem Cells/*metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2013-12-21
    Description: The duration of a woman's reproductive period is determined by the size and persistence of a dormant oocyte pool. Specific oocyte genes are essential for follicle maintenance and female fertility. The mechanisms that regulate the expression of these genes are poorly understood. We found that a cullin-ring finger ligase-4 (CRL4) complex was crucial in this process. Oocyte-specific deletion of the CRL4 linker protein DDB1 or its substrate adaptor VPRBP (also known as DCAF1) caused rapid oocyte loss, premature ovarian insufficiency, and silencing of fertility maintaining genes. CRL4(VPRBP) activates the TET methylcytosine dioxygenases, which are involved in female germ cell development and zygote genome reprogramming. Hence, CRL4(VPRBP) ubiquitin ligase is a guardian of female reproductive life in germ cells and a maternal reprogramming factor after fertilization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yu, Chao -- Zhang, Yin-Li -- Pan, Wei-Wei -- Li, Xiao-Meng -- Wang, Zhong-Wei -- Ge, Zhao-Jia -- Zhou, Jian-Jie -- Cang, Yong -- Tong, Chao -- Sun, Qing-Yuan -- Fan, Heng-Yu -- New York, N.Y. -- Science. 2013 Dec 20;342(6165):1518-21. doi: 10.1126/science.1244587.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Life Sciences Institute and Innovation Center for Cell Biology, Zhejiang University, Hangzhou 310058, China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24357321" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carrier Proteins/genetics/*metabolism ; Cell Survival/genetics/physiology ; Cellular Reprogramming/*genetics ; Cullin Proteins/genetics/metabolism ; DNA-Binding Proteins/genetics/*metabolism ; Dioxygenases/genetics/*metabolism ; Female ; Fertility/*genetics ; Gene Silencing ; Gonadal Dysgenesis/genetics ; HeLa Cells ; Humans ; Mice ; Mice, Knockout ; Oocytes/*physiology ; Ovary/physiopathology ; Proto-Oncogene Proteins/genetics/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2012-03-30
    Description: Glial cells constitute nearly 50% of the cells in the human brain. Astrocytes, which make up the largest glial population, are crucial to the regulation of synaptic connectivity during postnatal development. Because defects in astrocyte generation are associated with severe neurological disorders such as brain tumours, it is important to understand how astrocytes are produced. Astrocytes reportedly arise from two sources: radial glia in the ventricular zone and progenitors in the subventricular zone, with the contribution from each region shifting with time. During the first three weeks of postnatal development, the glial cell population, which contains predominantly astrocytes, expands 6-8-fold in the rodent brain. Little is known about the mechanisms underlying this expansion. Here we show that a major source of glia in the postnatal cortex in mice is the local proliferation of differentiated astrocytes. Unlike glial progenitors in the subventricular zone, differentiated astrocytes undergo symmetric division, and their progeny integrate functionally into the existing glial network as mature astrocytes that form endfeet with blood vessels, couple electrically to neighbouring astrocytes, and take up glutamate after neuronal activity.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777276/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777276/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ge, Woo-Ping -- Miyawaki, Atsushi -- Gage, Fred H -- Jan, Yuh Nung -- Jan, Lily Yeh -- 1K99NS073735/NS/NINDS NIH HHS/ -- 4R37MH065334/MH/NIMH NIH HHS/ -- MH090258/MH/NIMH NIH HHS/ -- P01 AG010435/AG/NIA NIH HHS/ -- R01 MH090258/MH/NIMH NIH HHS/ -- R37 MH065334/MH/NIMH NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 Mar 28;484(7394):376-80. doi: 10.1038/nature10959.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Department of Physiology, University of California at San Francisco, 1550 4th Street, San Francisco, California 94158, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22456708" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Astrocytes/*cytology/metabolism/physiology ; Cell Differentiation ; Cell Division ; *Cell Lineage ; Cell Proliferation ; Cerebral Cortex/*cytology ; Glutamic Acid/metabolism ; Mice ; Mice, Transgenic ; Neuroglia/*cytology/metabolism ; Time-Lapse Imaging
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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