Publikationsdatum:
2012-02-11
Beschreibung:
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a CTL-intrinsic fashion, determined plurifunctional effector cell differentiation, and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonilla, Weldy V -- Frohlich, Anja -- Senn, Karin -- Kallert, Sandra -- Fernandez, Marylise -- Johnson, Susan -- Kreutzfeldt, Mario -- Hegazy, Ahmed N -- Schrick, Christina -- Fallon, Padraic G -- Klemenz, Roman -- Nakae, Susumu -- Adler, Heiko -- Merkler, Doron -- Lohning, Max -- Pinschewer, Daniel D -- New York, N.Y. -- Science. 2012 Feb 24;335(6071):984-9. doi: 10.1126/science.1215418. Epub 2012 Feb 9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Immunology, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22323740" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Adoptive Transfer
;
Animals
;
Arenaviridae Infections/*immunology/pathology
;
Cell Differentiation
;
Gene Expression Profiling
;
Herpesviridae Infections/*immunology
;
Interleukin-33
;
Interleukins/genetics/immunology/*metabolism
;
Lymphocyte Activation
;
Lymphocytic choriomeningitis virus/*immunology/physiology
;
Mice
;
Mice, Transgenic
;
Necrosis
;
Receptors, Interleukin/genetics/metabolism
;
Recombinant Proteins/immunology
;
Rhadinovirus/*immunology
;
Signal Transduction
;
Stromal Cells/immunology/metabolism
;
T-Lymphocytes, Cytotoxic/*immunology/transplantation
;
Tumor Virus Infections/immunology
;
Up-Regulation
;
Vaccinia virus/immunology
;
Virus Replication
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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