Publication Date:
2012-10-16
Description:
The spatial organization of cell fates during development involves the interpretation of morphogen gradients by cellular signaling cascades and transcriptional networks. Recent studies use biophysical models, genetics, and quantitative imaging to unravel how tissue-level morphogen behavior arises from subcellular events. Moreover, data from several systems show that morphogen gradients, downstream signaling, and the activity of cell-intrinsic transcriptional networks change dynamically during pattern formation. Studies from Drosophila and now also vertebrates suggest that transcriptional network dynamics are central to the generation of gene expression patterns. Together, this leads to the view that pattern formation is an emergent behavior that results from the coordination of events occurring across molecular, cellular, and tissue scales. The development of novel approaches to study this complex process remains a challenge.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kicheva, Anna -- Cohen, Michael -- Briscoe, James -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2012 Oct 12;338(6104):210-2. doi: 10.1126/science.1225182.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Medical Research Council-National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23066071" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Body Patterning/*genetics
;
Drosophila/embryology/genetics
;
*Gene Expression Regulation, Developmental
;
Gene Regulatory Networks
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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